ID A0A2K5NQW9_CERAT Unreviewed; 5210 AA.
AC A0A2K5NQW9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ring finger protein 213 {ECO:0000313|Ensembl:ENSCATP00000039882.1};
GN Name=RNF213 {ECO:0000313|Ensembl:ENSCATP00000039882.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000039882.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000039882.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9531.ENSCATP00000039882; -.
DR Ensembl; ENSCATT00000064196.1; ENSCATP00000039882.1; ENSCATG00000042518.1.
DR GeneTree; ENSGT00630000089884; -.
DR OMA; NAYMKDM; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000042518; Expressed in spleen and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd16561; RING-HC_RNF213; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR031248; RNF213.
DR InterPro; IPR046439; ZF_RZ_dom.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22605:SF16; E3 UBIQUITIN-PROTEIN LIGASE RNF213; 1.
DR PANTHER; PTHR22605; UNCHARACTERIZED; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR Pfam; PF20173; ZnF_RZ-type; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51981; ZF_RZ; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 4019..4057
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 4490..4560
FT /note="RZ-type"
FT /evidence="ECO:0000259|PROSITE:PS51981"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3507..3545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..172
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..413
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3529..3543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5210 AA; 591449 MW; C76A87549118E768 CRC64;
MECPSCHHVS KEEAPRFCSQ CGERLPPAAP IADSENSNPT MASAPEGEME CGQVLEEEGG
PCLSPGSDSW QENPDEPGSD GSWTIQEGAA SEFLVDATVD LISDEWKAAH AIPRKRRKQD
AAPLEAAGVP SADCEQSKKK KRKKKKNLNN SASSELDSLS LSPASPCHLT LLSNPEPQDA
ARPHSQAQQS GPTGQLSQAP GTATMPLEGD GPSVPTKVGD SPLQAQALGE AGVATGGEAQ
SSRQPQDHTE GEDKDASIPS EGRGLSQEGA GPPISAGEGR SGNEDAAQEL LLPESKRGSS
EPGTEPQTTR QQAGTPASTA VDAAAEPANA VKGAGKEMKE KIQGMKQPPT TTTASKTHCQ
EAETKTKDET ATAGEKVGKN EQGEPEDPKK PEGKNKSAAA AKKEKEQKNQ KAGVQEVKAR
TLSPGRGVTV YFHAIISNHF SFNPDHHKVF IRGGEELGEP KWSRNVCELH CTRDLHRDGI
LVEGSAVISK KYLNKYIPYK YVICNNKGSA EYEFIYKRQQ KEGEYVNRCL FIKSSLLGSG
DWHQYDDIVC MRPPGKLQKV MNHIADFTRK DLVKGKQIAA TVMLDGIFSI LQTWDTINLN
NFFTQFQQFY FVVRQPMIYE GHAQPWTALQ YGEKEVKKDL WEYLQKHMAP FLEGKSADLF
PKDCPVRSKL KMGLIILFVV EKFQLEDNLT SMCNLLSSDA SSPDELHSDL SHILGTSQSW
RLYLVNLCQR CMDKSMYHWL GTLPVLHCCM ELAPRHKDAW SQPEDTWAAL EGISFSQFRE
QTQDTSCLLR FMRENERLLS VDEPLFRSWF SLLPLSHLVP YMENFIEHLG HFPAHVLDCF
LGTYYRLRGL QKISFRSMQD VLNILKMLLH LLDTYQDKIP EEALSPSYLT VCLKLHEAVC
NSTKTHEFYE LPALSAEIVC RMIILLSLVD SAGQGDATGN NSVQTVFQGT LAATKRWLRE
VFTNNMLVYS GVSFTYHKEI EVWRRLVEIY FPVEHGWKES LLEDMEWRLK QEKPLSQITA
YCSSHWDSEG LEDSVAKTFE KCIIEAVSSA CQSQTSILRG LSCYNLQKFG TLLSAVITKS
WPRNNGEAVD NLDDILKHLL TWADVKHLFK LCGTNEEILA NITEDGKKLM GAADSVFMKI
AGDLRNGTIL VGQLELIIKH KNQFLDIWQL KEKSLSPQDE KCTMEEALNW RMEELLFLEK
EKRCVDSLLK MCGNVKHLIQ VDFGELATRH SQDLSSKRLN EAVTVRLPTS SNSERETHYH
LSSQVREMAG KIDLLRDSHI FQIFWRKAAE PLSEPKEEQE AAELLSEPEE ESEKHILELE
EVYDYLYQPS YRKFIKLYQD LKSGEVTLAE IDVIFKDFVN KYTDLVSELK IMCTVDHQGQ
RDWIKERVEQ IKEYHHLHQA VHAAKVILQV KESLGLTGDF SVLNTLLNFT DDFDNFGHET
LDQINQELIR AKKLLQDISE ARCEGLKALS LRKEFIRWVR EALGGINELK VFVDLASISA
GENDIDVDRV ACFHDAVQGY ASLLFKLDPR VGFDAFMKHL KELWKALDND QYLPRKLYDS
ARNLEWLKTV KESHGSVELS SLTLATAINQ RGIYVIHAPK GGQKISPDTV LHLVLPGSPG
SHEEPREYCL EELKELLNKL MLMSGKKDHK NTEVERFSEV FCGVQRLSQA FIDLHSAGNM
LFRTWTAMAY CSPKQSVSIR MNFGLELVTE LVEGGDVTEL LAALCRQMEH FLDSWKKFVT
QKRMEHFYLN FYTAEQLVYL STELRKQPPS DAALTMLSFI KSNCTLMDVL RASVGCESEA
TRYRVRTVTE ELPLMLFSEF SLADKLRVIM EQSRECLPAF LPDCLDLETL GRCLAHLAGM
GGSPVERHLP RGLQVGQPNL VVCGHSEVLP AALAVYMQTP SQPLPTYDEV LLCTPATTFE
EVALLLRRCL TLGSPGHKVY SLLFADQLSY EVARQAEELF QKLCTQQHRE DYQLVMVCDG
DWEHCYLPSA FSQHKVFVTP QAPLEAIQAY LADHYRVPKQ TLSAAAVFKD RLCVGIVASE
RAGVGKESGR VGGPRLPGTI IVTKSKIRGV LGVGRTRHRV VCLHLVQTGI WVFLFKLLIL
QYLMDINGKM WLRNPCHLYI IEILERRTSV PSRRSSKLRT RVPQFSFLDI FPKVTCRPPK
EVIDMELSPR RSDTEPGMDQ WEFCSETFQR PYQYLRRFHQ NQDLDMFQYQ EGSVEGTPEE
CLQHFLIYCG VINPSWSELR NFARFLNYQL RDCEASLFCN PSFIGDTLRG FKNFVVTFMI
FMARDFATPT LHTSDQSPGK HMVTMDGVKE EDLAPFSLRK RWESEPHPYV FFNDDRTTMT
FIGFYLQPNS KGSVDAINHL TGKVIKRDVM TMDLYQGLLL QRVPFNVDFD KLPRHEKLER
LCLTLGIRWA IDPDETYELT TDNMLKILAI EMRFRCGIPV IIMGETGCGK TRLIKFLSDL
RRAGADADTI KLVKVHGGTT ADMIYSRVRE AENVAFANKD QHQLDTILFF DEANTTEAVS
CIKEVLCDRM VDGQPLARDS GLHIIAACNP YRKHSEEMIC RLESAGLGYR VSAEETADKL
GSIPLRQLVY RVHALPPSLI PLVWDFGQLS DAAEKLYIQQ IVQRLVDSIS LDENKTRVIT
EVLCASQGFM RKREDECGFV SLRDVERCVK VFRWFHEHSA MLLAQLNSFL SKSSVSKNHL
ERDPVLWSLL LAVGVCYHAS LEKKDSYRKA IARFFPKPYD DSRLLLDEIT RAQDLFLDGI
PLRKTIAKNL ALKENVFMMV ICIELKIPLF LVGKPGSSKS LAKTIVADAM QGPAAYSDLF
RSLKQVHLVS FQCSPHSTPQ GIIGTFRQCA RFQQGKDLQQ YVSVVVLDEV GLAEDSPKMP
LKTLHPLLED GCIEDDPAPH KKVGFVGISN WALDPAKMNR GIFVSRGSPN KRELIDSAKG
ICSSDSLIQD RIQGYFASFA KAYETVCENQ DKEFFGLRDY YSLIKMVFAA AKASNRKPSP
QDIAQAVLRN FSGKDDIHAL DIFLANLPEA KCSEEVSPLQ LIKQNIFGPS QKVPGGQLED
AESRYLLLLT KNYVALQILQ QTFFKEDQQP EIIFGSGFPK DQEYTQICRN INRVKICMET
GKMVVLLNLQ NLYESLYDAL NQYYVHLGGQ KYVDLGLGTH RVKCRVHPNF RLIVIEEKDI
VYKHFPIPLI NRLEKHYLDI NTVLEKWQKS VVEELRAWVE KFIDVKAEHF LNRHKYSPSD
VFIGYHSDAC ASVVLQVIER QGHREALTEE LYQKVSEAAR LILLNCATPD AVVRLSAASL
GSFPGKSLSQ EYFYRQRHNS FADFLQTHLH TTDLERHAVF TEITTFSRLL TSHDCEILES
EVTGRASKLT LLWLQRFDTE FSFLKEVRNC LTNTAKCKIL IIQTDFEDGI HSAQLIASAK
YSAINEINKI QENEDRIFVY FITKLSRMGR GTAYVGFHGG LWQSVHIDDL RRSTLMVSDM
TRLQSVTISQ LFAPGDLPEL GLEHRAEDGR EEAMETEAST SGEVAEEAME TEGSEKVEKE
TSELGGSDVS ILDTTRLLRS CVQSAVGMLR DQNESCTRNM RRVVLLLDLL NEDSACHASF
LRVSKMRLNV LLKTQEESQL HTLEWVAREA CNQDALQEAG TFRHTLWKRV QGAVTPLLAS
MISFIDRDGN LELLTRPDTP PWARDLWMFI FSDMKLLNIP LVMNNARHKG EMAYIMVQNY
MNLSENASNN VPFSWRIKDY LEELWVQAQY ITDAEGLPKK FVDIFQQTPL GRFLAQLHGE
PQQELLQCYS KDFILLTMRV ATEEELEFLQ MALWSCIREL KAASEAPEEE VSLPWVHLAY
QRFRSRLQNF SRILTIYPQV LHSLTEAPRN HELAGCEMTL DAFAAMACTE MLTRDTLKPS
PQAWLQLVKN LSMPLELICS DGHMQGSGSL AQAVIREVRA QWSRIFSTAL FVEHVLLGTE
SRVPELCRLV TEHVFLLDKC LRENSDVKTH RPFEAVMSTL CECKERASKT LSRFGVQPCP
ICLGDAQDPV CLPCDHVYCL RCLRAWFAPG QMMCPYCLTD LPDTFSPTVS QRHREVIEKH
ARFRQMCNSF FVDLVSTMCF KDNAPPEKEV IESLLSLLFV QKELLRDAPQ RRREHTKSLS
PFNDVVDKTP VIRSVILKLL LKYSFDDVKD YIQDYLTLLK KKAFIIEDKT ELYMLFISCL
EDSIREKTSA CSRNDELNHL REEGRFLNTY SPVRRGREPA NEASVEYLQE VARIRLCLDR
ASDFLSQPEG GPGMAEEKQC YLRQVKHFCT RVENDWHRVY LVRKLSSQRG MEFVQGLSKP
GHPCQWVFPK QVIEQQKDHP GQMDRYLVYG DEYKALRDAV AKAVLECKPL GIKTALKVGW
ARWWTTDVAH HVTLYWHFFS CQQCEAVSKF IGECKILSPP EISHFATSLV DNSLPLLRVG
PSDNHLQGTV TEMAIHAAAI LLCGQNKVLE PLKNLAFSPA NMAHAFLPTM PEDLLAQARR
WKGLEGVHWY TCPNGHPCSV GEVSLAVEQS TCIDSPCADW SINHRPQDGF NLNSTDRTQT
GHVLGDPQQR DVVTCDRGLP PVVFILIRLL THLALLLGAS QSSQALINII KPPVRDPKGF
LQQHILKDLE QLTKMLGHSA DETISVVHLV LRRLLQEQHQ LSGKRFLNFD TRLSTKEMRN
NWEKEIAAVI SPELEHLDKT LPTMNILISQ DKRISSNPVA KIIYGDPVTF LPHLPRKSVV
HCSKIWSCRK RITVEYLQHI VEQKNGKERV PILWHFLQKE AELRLVKFLP EILALQKGLV
KRFQNVPQVE YSSIRGFLSS HSSEGLRQLL QKRITIFLST WNKLRRSLET NGEINLPKDY
CSTDLDLDAD FEILLPRRRG LGLCATALVS YLIRLHNEIV YAVEKLSEGN NSYSVDAADV
TDLHVISYEV ERDLTPLILS NCQYQVEQGR ETLQEFDLEK IQRQIVSRFL QGKPRLSLKG
IPTLVYRHDW NYEHLFMDIK NKMAQDSLPS SVISAISGQL QSYSDACEAL SVVEVTLGFL
STAGGDPNMH LNMYIQDVLR MGDQTTHVSK ALDRCQLKHT IALWQFLSAH KSEQLLRLQK
EPFGEISSRY KADLSPEDAK LLSTFLNQIG LDAFLLELHE MIILKLKNPQ TEGSFNPKWS
LRDTLVSYME TKENEILPEM ESQFPEKILL ASCVSVWKTA AVLKRDRQMR
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