ID A0A2K5NR06_CERAT Unreviewed; 723 AA.
AC A0A2K5NR06;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Low-density lipoprotein receptor {ECO:0000256|ARBA:ARBA00039475};
GN Name=LDLR {ECO:0000313|Ensembl:ENSCATP00000039917.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000039917.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000039917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Late endosome {ECO:0000256|ARBA:ARBA00004603}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A2K5NR06; -.
DR Ensembl; ENSCATT00000064231.1; ENSCATP00000039917.1; ENSCATG00000042525.1.
DR GeneTree; ENSGT00940000161046; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000042525; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270:SF21; LOW-DENSITY LIPOPROTEIN RECEPTOR; 1.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 4.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 4.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 4.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..723
FT /note="Low-density lipoprotein receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014325872"
FT TRANSMEM 656..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 308..354
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 355..397
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 398..441
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 442..486
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 27..39
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 34..52
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 68..80
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 75..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 87..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 107..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 114..132
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 156..168
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 163..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 175..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 723 AA; 79697 MW; 0403809BF1E36D55 CRC64;
MGPWGWKLRW TVAFLLAAAE AAVGDRCERN EFQCEDGKCI SYKWVCDGTA ECQDGSDESQ
ETCSPKTCSQ DEFRCHDGKC IYRQFVCDSD RDCLDGSDEA SCPVLTCGPA SFQCNSSTCI
PQLWACDNDP DCEDGSDEWP QRCQGLEVPK RDSSPCSAFE FHCRSGECIH SGWRCDGGPD
CKDKSDEENC PVATCRPDEF PVSDGTASMG SGSVTREYDC KDLSDEVGCI NGEPSQSAGI
TGGLHCACSY QEVLFHPVFL GASSGSIAYL IFTNRHEVRK MTLDRSEYTS LIPNLRNVVA
LDTEVASNRI YWSDLSQRMI YSTQLDRAHS VSSYDTVISR DLQAPDGLAV DWIHSNIYWT
DSVLGTVSVA DTKGVKRKTL FRENGSKPRA IVVDPVHGFM YWTDWGTPAK IKKGGLNGVD
IYSLVTENIQ WPNGITLDFP SGRLYWVDSK LHSISSINVN GGNRKTVLED EKRLAHPFSL
AIFEDKVFWT DIINEAIFSA NRLTGSDINL LAENLLSPED MVLFHNLTQP RGVNWCERTT
LSNGGCHYLC LPAPQINPQS PKFTCTCPDG MLLAKDMRSC LTEAEAAVAT QETSTVRLMV
SSKAVATQHT TTRPVPNTSQ LPGATPGLTT AETVTMSHQA LGDVAGRGNE KKPKSVGALS
IVLPIVLLVF LCLGAFLLWK NWRLKSINSI NFDNPVYQKT TEDEVHICRN QDGYSYPSVS
DPL
//
