ID A0A2K5NUZ8_CERAT Unreviewed; 1201 AA.
AC A0A2K5NUZ8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=ERBB4 {ECO:0000313|Ensembl:ENSCATP00000041344.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000041344.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000041344.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR AlphaFoldDB; A0A2K5NUZ8; -.
DR Ensembl; ENSCATT00000065745.1; ENSCATP00000041344.1; ENSCATG00000043272.1.
DR GeneTree; ENSGT00940000154695; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000043272; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0043235; C:receptor complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR CDD; cd00064; FU; 3.
DR CDD; cd05110; PTKc_HER4; 1.
DR CDD; cd12092; TM_ErbB4; 1.
DR Gene3D; 6.10.250.880; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 3.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049328; TM_ErbB1.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF90; RECEPTOR TYROSINE-PROTEIN KINASE ERBB-4; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF21314; TM_ErbB1; 1.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 5.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000619}.
FT TRANSMEM 545..568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 611..878
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1010..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 736
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 617..625
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 644
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1201 AA; 134827 MW; E7027317EFD91A36 CRC64;
MGNLEITSIE HNRDLSFLRS VREVTGYVLV ALNQFRYLPL ENLRIIRGTK LYEDRYALAI
FLNYRKDGNF GLQELGLKNL TEILNGGVYV DQNKFLCYAD TIHWQDIVRN PWPSNLTLVS
TNGSSGCGRC HKSCTGRCWG PTENHCQTLT RTVCAEQCDG RCYGPYVSDC CHRECAGGCS
GPKDTDCFAC MNFNDSGACV TQCPQTFVYN PTTFQLEHNF NAKYTYGAFC VKKCPPCDGI
GTGSLMSAQT VDSSNIDKFI NCTKINGNLI FLVTGIHGDP YNAIEAIDPE KLNVFRTVRE
ITGFLNIQSW PPNMTDFSVF SNLVTIGGRV LYSGLSLLIL KQQGITSLQF QSLKEISAGN
IYITDNSNLC YYHTINWTTL FSTINQRIVI RDNRKAENCT AEGMVCNHLC SSDGCWGPGP
DQCLSCRRFS RGRICIESCN LYDGEFREFE NGSICVECDP QCEKMEDGLL TCHGPGPDNC
TKCSHFKDGP NCVEKCPDGL QGANSFIFKY ADPDRECHPC HPNCTQGCIG SSIEDCIGLM
DRTPLIAAGV IGGLFILVIV GLTFAVYVRR KSIKKKRALR RFLETELVEP LTPSGTAPNQ
AQLRILKETE LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD
EALIMASMDH PHLVRLLGVC LSPTIQLVTQ LMPHGCLLEY VHEHKDNIGS QLLLNWCVQI
AKGMMYLEER RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM
ALECIHYRKF THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI
DVYMVMVKCW MIDADSRPKF KELAAEFSRM ARDPQRYLVI QGDDRMKLPS PNDSKFFQNL
LDEEDLEDMM DAEEYLVPQA FNIPPPIYTS RARIDSNRSE IGHSPPPAYT PMSGNQFVYR
DGGFAAEQGV SVPYRAPTST IPEAPVAQGA TAEIFDDSCC NGTLRKPVAP HVQEDSSTQR
YSADPTVFAP ERSPRGELDE EGYMTPMRDK PKQEYLNPVE ENPFVSRRKN GDLQALDNPE
YHSASNGPPK AEDEYVNEPL YLNTFANALG KADYLKNNVL SVPEKAKKAF DNPDYWNHSL
PPRSTLQHPD YLQEYSTKYF YKQNGRIRPI VAENPEYLSE FSLKPGTVLP PPPYRHRNTV
V
//
