ID A0A2K5NWH9_CERAT Unreviewed; 934 AA.
AC A0A2K5NWH9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Protocadherin gamma subfamily A, 4 {ECO:0000313|Ensembl:ENSCATP00000041755.1};
GN Name=PCDHGA4 {ECO:0000313|Ensembl:ENSCATP00000041755.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000041755.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000041755.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Potential calcium-dependent cell-adhesion protein. May be
CC involved in the establishment and maintenance of specific neuronal
CC connections in the brain. {ECO:0000256|ARBA:ARBA00003436}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A2K5NWH9; -.
DR Ensembl; ENSCATT00000066184.1; ENSCATP00000041755.1; ENSCATG00000043500.1.
DR GeneTree; ENSGT00940000163745; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000043500; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR031904; Cadherin_CBD.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF84; PROTOCADHERIN GAMMA-A11; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR Pfam; PF15974; Cadherin_tail; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 689..714
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..133
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 134..242
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 243..347
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 348..452
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 453..562
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 579..676
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 804..843
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 904..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 101372 MW; 37FF5E1B7E736584 CRC64;
MANRLQRLDR SGLMLLCIFL GTLRGFRAGQ IRYSVPEETE KGYFVGNISK DLGLEPRELA
KRGVRIVSRG KTQLFAVNLR SGSLITAGRI DREELCETVS SCFLNMELLV EDTLKIYGVE
VEIIDINDNA PSFQEDEVEI KVSEHAIPGA RFALPNARDP DVGVNSLQSY QLSPNSYFSL
QLRGRMDGAK NPELVLEGSL DREKEAAHLL LLTALDGGDP IRKGSVPIRV VVLDVNDHIP
VFTQSVYRVS VPENISSGTR VLVVNATDPD EGINGEVMYS FRNMESKASE IFQLDSQTGE
VLVRGSLDFE KYGFYEMEIQ GQDGGGLFTT AMMLITVVDV NDNAPEITIT SSINSILENS
PPGTVIALLN VQDQDSGENG QVSCFIPNHL PFKLEKTYGN YYKLITSRVL DRELVQSYNI
TLTATDQGSP PLSSETHIWL NVADDNDNPP VFPHSSYFAY IPENNPRGAS IFSVTALDPD
SKQNALVTYS LTDDTVQGVP LSSYVSINSN TGVLYALQSF DYEQFRDLQL RVIARDSGDP
PLSSNVSLSL FVLDQNDNAP EILYPALPTD GSTGVELAPR SAEPGYLVTK VVAVDKDSGQ
NAWLSYRLLK ASEPGLFAVG EHTGEVRTVR ALLDRDALKQ SLVVAVQDHG QPPLSATVTL
TVAVADSIPE VLADLVSLES LANSETSDLT LYLVVAVAAV SCIFLVFVVV LLALRLWRWH
KSRLLQASEG GLAGMPTSHF VGVDGVQAFL QTYSHEVSLI ADSQKSHLIF PQPNYGDTLI
SQESCEKSEP LLIAEDSAII LGKCDPTSNQ QAPPNTDWRF SQAQRPGTSG SQNGDDTGTW
PNNQFDTEML QAMILASASE AADGSSTLGG GAGTMGLSAR YGPQFTLQHV PDYRQNVYIP
GSNATLTNAA GKRDGKAAAG GNGNKKKSGK KEKK
//
