ID A0A2K5P1L9_CERAT Unreviewed; 710 AA.
AC A0A2K5P1L9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase like 1 {ECO:0000313|Ensembl:ENSCATP00000043597.1};
GN Name=NAALADL1 {ECO:0000313|Ensembl:ENSCATP00000043597.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000043597.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000043597.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR AlphaFoldDB; A0A2K5P1L9; -.
DR Ensembl; ENSCATT00000068036.1; ENSCATP00000043597.1; ENSCATG00000044328.1.
DR GeneTree; ENSGT01030000234598; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000044328; Expressed in liver and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 170..256
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 318..526
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 586..705
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 710 AA; 77356 MW; 04450DBA8DC7D55D CRC64;
MQWTKVLGLG LGAAALLGLG IILGHFAIPK KANSPAPSDL DLEILETVMG QLDAHRIREN
LRELSREPHL ASSPRDEDLV QLLLQRWKDP ESGLDSAEAF TYEVLLSFPS QEQPNVVDIA
MTLPPPPTVG PTGDIIHSCH RTEENVTGEQ GGPDVVQPYA AYAPSGTPQG LLVYANRGTE
EDFKELQTQG IKLEGTIALT RYGGVGRGAK AVNAAKHGVA GVLVYTDPAD INDGLSLPNE
TFPYSWYLPP SGVERGSYYK YFGDPLTPYL PAIPSSFRLD LANVSGFPPI PTQPIVCSLG
CPVNVSVYNR LELRNSSNVL GIIRGAVEPD RYVLYGNHRD SWVHGAVDPS SGTAVLLELS
RVLGTLLKKG TWRPRRSIVF ASWGAEEFGL IGSTEFTEEF FNKLQERTVA YINVDIAVFA
NATLRVQGTP PVQSVVFSAT KEIRSPGPGD LSIYDNWIRY FNRSSPVYGL VPSLGSLGAG
SDYAPFIHFL GISSMDIAYT YDRSKTSARI YPTYHTAFDT FDYVDKFLDP GFSSHQAVAR
TAGSIILRLS DSFFLPLKVS DYSETLRSFL QAAQQDLGAL LEQHSISLGP LVTAVEKFEA
AAAALGQRIS VLQKGSPDPL QVRMLNDQLM LLERTFLNPR AFPEERYYSH VLWATRTGSV
ATFPGLSNAC SRARDTASGS EAWAEVQRQL SIVVTALEAA AATLRPVADL
//
