ID A0A2K5P341_CERAT Unreviewed; 616 AA.
AC A0A2K5P341;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator like 3 {ECO:0000313|Ensembl:ENSCATP00000044144.1};
GN Name=RGL3 {ECO:0000313|Ensembl:ENSCATP00000044144.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000044144.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000044144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5P341; -.
DR STRING; 9531.ENSCATP00000044144; -.
DR Ensembl; ENSCATT00000068585.1; ENSCATP00000044144.1; ENSCATG00000044559.1.
DR GeneTree; ENSGT00940000161935; -.
DR OMA; RLSWVIE; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000044559; Expressed in liver and 1 other cell type or tissue.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd17212; RA_RGL3; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 2.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR030750; RGL3_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF220; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 54..193
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 173..413
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 519..606
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 17..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 323..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..457
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..509
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 616 AA; 67468 MW; 1735DA51D79DFA74 CRC64;
APLQDWGEET EDGAVYSVSL RRQRSQRLSP AEGTGGSQAP SPIANTFLHY RTSKVRVLRA
ARLERLVGEL VSGDREQDPS FVPAFLATYR TFVPTAHLLG FLLPPMPPPP PPGSVVNQNL
HVPHPRPPVG HGRTCTPAWQ QKVAQTSDPD SAEACAEEEE GIMPQAPQLL DFNVDEVAEQ
LTLMDLELFS KVRPYECLGS VWSQRDRPGA AGASPTVRAT VAQFNTVIGC VLGSVLGAPG
LTAPQRAQRL EKWIRIAQRC RELRNFSSLR AILSALQSNP IYRLKRSWGA VSREPLSTFR
KLSQIFSDEN NHLSSREILF QEEATEGSQK EDNTPGSLPS VDGISYGPER KVSGGYSGLI
PQEWEILARI QQLQRRCQSY TLSPHPPILA ALHAQRQLSE EQSYRLSRVI EPPAASCPSS
PRIQRRISLT KRLSAKLSRE KSSFPSWSPG NPSSPTSSVS PGSPPSSPRS RDAPAGSPPA
SPGPQGPSTK LPLSPDLPRP GPLPLGSPRI PLPAQQSSEA RVIRISIDND HGNLYRSILL
TSQDKAPSVV QRALQKHNVP QPWARDYQLF QVLPGDRELL IPDNANVFYA MSPAAPGDFM
LRRKEGTRHT LSVSPT
//
