ID   A0A2K5P3B5_CERAT        Unreviewed;      1294 AA.
AC   A0A2K5P3B5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Inter-alpha-trypsin inhibitor heavy chain family member 6 {ECO:0000313|Ensembl:ENSCATP00000044203.1};
GN   Name=ITIH6 {ECO:0000313|Ensembl:ENSCATP00000044203.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000044203.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000044203.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the ITIH family.
CC       {ECO:0000256|ARBA:ARBA00010158}.
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DR   STRING; 9531.ENSCATP00000044203; -.
DR   Ensembl; ENSCATT00000068644.1; ENSCATP00000044203.1; ENSCATG00000044595.1.
DR   GeneTree; ENSGT00940000162980; -.
DR   OMA; LPRWASC; -.
DR   Proteomes; UP000233060; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0030212; P:hyaluronan metabolic process; IEA:InterPro.
DR   CDD; cd01461; vWA_interalpha_trypsin_inhibitor; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR010600; ITI_HC_C.
DR   InterPro; IPR013694; VIT.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10338; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR10338:SF155; INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H6; 1.
DR   Pfam; PF06668; ITI_HC_C; 1.
DR   Pfam; PF08487; VIT; 1.
DR   Pfam; PF00092; VWA; 1.
DR   SMART; SM00609; VIT; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS51468; VIT; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           24..1294
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014399056"
FT   DOMAIN          21..150
FT                   /note="VIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51468"
FT   DOMAIN          264..450
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          593..622
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          675..695
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          766..917
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..622
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        774..788
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        840..858
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        859..881
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        882..908
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1294 AA;  141518 MW;  A9E5EF731E5B9350 CRC64;
     MSGWRYLICV SFLLTILLEL TYQGPPVPAS SSTKLLMTSY SMHSTVVSRY AHTLVTSVLF
     NPHAEAHEAI FDLDLPHLAF ISNFTMTINN KVYIAEVKEK HQAKKIYEEA HQQGKTAAHV
     GIRDRESEKF RISTSLAAGT EVTFSLAYEE LLQRHQGHYQ LVVSLRPGQL VKRLSVEVTV
     SERTGISYVH IPPLRTSRLR TNAHASEADL PPSTRIERGE ITGQPETSVS IMADFLDIIR
     DMQIYDGYFI HYFAPRGLPP MEKNVVFVID VSGSMFGTKM EQTKKAMNVI LSDLRANDYF
     NIISFSDTIN VWKAGGSIQA TIQNVHSAKD YLHRMEADGW TDINSALLAA ASVLNYSNQE
     PGRGPSAGRI PLIIFLTDGE PTAGVTTPSV ILSNVRQAVG HRVSLFTLAF GDDADFTLLR
     RLSLENRGIA RRIYEDTDAA LQLEGLYEEI SMPLLADVRL NYLGGLVGAS PWAVFPNYFG
     GSELVVAGQV QPGKQELGIH LAARGPKDQL LVARHSEGAT NNSQKTFGCP GEPAPNVAHF
     IRRLWAYVTI GELLDARFQA RDTTIRHLLA AKVLNLSLEY NFVTPLTSLV MVQPKEASEE
     TRRQTSTSAG PDTIMPSSSS RHGLGISTAQ PALVPKVISP KSRPVKPKFY LSSTTTASTK
     KMLSSKELEP LGESLHTLST PTYPKAKTPA QQDSGTLAQA TLRTKPTILV PSNSGTLLPL
     KLSTLSHQNL DILPMNSKTQ VSPLKPGIPA LPKADTVKHV TPLHCRPGAP SHPQLGALTS
     QSPKGLPQPR PGVSTLQVPK YPPHSRLRVP APKTRNNMPH PRPGILLSKT PKVSLSLKPS
     APPHQISTSI SISKPETPNP HMPQTPLPPR PDRPRPPLPE SLSTFPNTIS SSTGPSSTTT
     TSVLGEPLPT PFTPTLPPGR FWHQHDLLPG PQRTRQVLVP SRPGVPTMSL LNSSRPTPEG
     SPPNLPILLP SSILPEAISL LLLPEELQLL SESMVESKFV ESLNPPVFYT LLTPDEDGSP
     NWDGNSEEIL GGAGGSMESQ GSSVGLAKGT LPSIFTFSSS VDGDPHFVIQ IPHSEEKICF
     TLNGHPGDLL QLIEDPKAGL HVSGKLLGAP PRPGRKDQTR TYFQIITVTT DKPRAYTITI
     SRSSISLRGE GTLRLSWDRP ALLKRPQLEL YVAAAARLTL RLGPYLEFLV LRHRYRHPST
     LQLPHLGFYV ANGSGLSPSA RGLIGQFQHA DIRLVTGPMG PCLRRHHGPD VPVILGKRLL
     KDSPRLLPRW ASCWLVKRSH VELLLGHPYL SYVL
//