ID A0A2K5P3L4_CERAT Unreviewed; 737 AA.
AC A0A2K5P3L4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Major facilitator superfamily domain containing 6 {ECO:0000313|Ensembl:ENSCATP00000044280.1};
GN Name=MFSD6 {ECO:0000313|Ensembl:ENSCATP00000044280.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000044280.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000044280.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. MFSD6 family.
CC {ECO:0000256|ARBA:ARBA00005241}.
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DR RefSeq; XP_011902690.1; XM_012047300.1.
DR AlphaFoldDB; A0A2K5P3L4; -.
DR Ensembl; ENSCATT00000068721.1; ENSCATP00000044280.1; ENSCATG00000044632.1.
DR GeneID; 105579953; -.
DR CTD; 54842; -.
DR GeneTree; ENSGT00530000063599; -.
DR OMA; GHVRVMY; -.
DR OrthoDB; 5353125at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000044632; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd17335; MFS_MFSD6; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR024989; MFS_assoc_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR16172:SF2; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 6; 1.
DR PANTHER; PTHR16172; UNCHARACTERIZED; 1.
DR Pfam; PF12832; MFS_1_like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..152
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 514..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 607..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 72..606
FT /note="Major facilitator superfamily associated"
FT /evidence="ECO:0000259|Pfam:PF12832"
FT REGION 22..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..429
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 668..685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 82488 MW; DE4DBCD9F00A83AD CRC64;
MADDKVAILT DDEEEQKRKY VLADPFNGIS REPEPPSNET PSSTETSAIP EEEIDWIEKH
CVKINNDLLI SKVFYFFFYS AYGSLYPLLP VYYKQLGMSP SQSGLLVGIR YFIEFCSAPF
WGVVADRFKK GKIVLLFSLL CWVLFNLGIG FVKPATLRCV PKIPPTAHPT NASHQLTILP
TNSSFTSFLT ISPKMREKRN LLLETGLNVS DTVTLPTALN MNSEPTLQPQ TDEITNRMMD
LTLNSSTATP VVPPGSVTKE TTTVIVTTTK SLPSDQVMLV YDQQEVEAIF LVILVVVIIG
EFFSASSVTI VDTVTLQYLG KHRDRYGLQR MWGSLGWGLA MLSVGIGIDY THIEVLIDGK
GCKPPEYRNY QIVFIVFGVL MTMALIVATQ FRFRYNHFKN NDSKGKEVEI PQVERNNSTE
SSEETPTTTS HSQAFNFWDL IKLLCSVQYG SVLFVAWFMG FGYGFVFTFL YWHLEDLNGT
TTLFGVCSVL SHVSELTAYF FSHKLIELIG HIRVLYIGLA CNTARYIYIS YLENAWTVLP
MEVLQGVTHA AIWAACISYL SAAVPPELRT SAQGILQGLH LGLGRGCGAM IGGVLVNYFG
AAATFRGIGM ACLVILLLFA LIQWLAVPDE EEDKTMLAER IPVPSSPVPI ATIDLVQQQT
EDVMPRIEPR LPPKKTKHQE EQEDVNKPAW GVSSSPWVTF VYALYQIKEM MQLTRDNRAS
EIQPLQLHIG KEMKGDQ
//
