ID A0A2K5P772_CERAT Unreviewed; 540 AA.
AC A0A2K5P772;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nuclear receptor subfamily 5 group A member 2 {ECO:0000313|Ensembl:ENSCATP00000045507.1};
GN Name=NR5A2 {ECO:0000313|Ensembl:ENSCATP00000045507.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000045507.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000045507.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR5
CC subfamily. {ECO:0000256|ARBA:ARBA00007536}.
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DR AlphaFoldDB; A0A2K5P772; -.
DR Ensembl; ENSCATT00000069953.1; ENSCATP00000045507.1; ENSCATG00000045134.1.
DR GeneTree; ENSGT00940000153391; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000045134; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd07167; NR_DBD_Lrh-1_like; 1.
DR CDD; cd07069; NR_LBD_Lrh-1; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR016355; NR5-like.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24086; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A; 1.
DR PANTHER; PTHR24086:SF18; NUCLEAR RECEPTOR SUBFAMILY 5 GROUP A MEMBER 2; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PIRSF; PIRSF002530; Nuc_orph_FTZ-F1; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 82..157
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 299..538
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT BINDING 420..423
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 515
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
FT BINDING 519
FT /ligand="a phosphatidylglycerol phosphate"
FT /ligand_id="ChEBI:CHEBI:60522"
FT /evidence="ECO:0000256|PIRSR:PIRSR002530-1"
SQ SEQUENCE 540 AA; 61256 MW; 450C70EFADBFB205 CRC64;
KSTCGEINEC QLLNLCCPCP GAGLPDRHGS PVPARGRLVM LPKVETEALG LARSHGEQGQ
MPENMQVSQF KMVNYSYDED LEELCPVCGD KVSGYHYGLL TCESCKGFFK RTVQNNKRYT
CIENQNCQID KTQRKRCPYC RFQKCLSVGM KLEAVRADRM RGGRNKFGPM YKRDRALKQQ
KKALIRANGL KLEAMSQVIQ AMPSDLTISS AIQNIHSASK GLPLNHAALP PTDYDRSPFV
TSPISMTMPP HGSLQGYQTY GHFPSRAIKS EYPDPYTSSP ESIMGYSYMD SYQTSSPASI
PHLILELLKC EPDEPQVQAK IMAYLQQEQA NRSKHEKLST FGLMCKMADQ TLFSIVEWAR
SSIFFRELKV DDQMKLLQNC WSELLILDHI YRQVVHGKEG SIFLVTGQQV DYSIIASQAG
ATLNNLMSHA QELVAKLRSL QFDQREFVCL KFLVLFSLDV KNLENFQLVE GVQEQVNAAL
LDYTMCNYPQ QTEKFGQLLL RLPEIRAISM QAEEYLYYKH LNGDVPYNNL LIEMLHAKRA
//
