ID A0A2K5TJ43_MACFA Unreviewed; 336 AA.
AC A0A2K5TJ43;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Platelet-derived growth factor D {ECO:0000256|ARBA:ARBA00018876};
GN Name=PDGFD {ECO:0000313|Ensembl:ENSMFAP00000000038.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000000038.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000000038.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000000038.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with PDGFRB homodimers,
CC and with heterodimers formed by PDGFRA and PDGFRB.
CC {ECO:0000256|ARBA:ARBA00026039}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the PDGF/VEGF growth factor family.
CC {ECO:0000256|ARBA:ARBA00006686}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; A0A2K5TJ43; -.
DR STRING; 9541.ENSMFAP00000000038; -.
DR Ensembl; ENSMFAT00000028203.2; ENSMFAP00000000038.2; ENSMFAG00000035368.2.
DR VEuPathDB; HostDB:ENSMFAG00000035368; -.
DR GeneTree; ENSGT00940000159575; -.
DR OrthoDB; 3908391at2759; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000035368; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:InterPro.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00135; PDGF; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR000072; PDGF/VEGF_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR11633; PLATELET-DERIVED GROWTH FACTOR; 1.
DR PANTHER; PTHR11633:SF4; PLATELET-DERIVED GROWTH FACTOR D; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00341; PDGF; 1.
DR SMART; SM00042; CUB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50278; PDGF_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Mitogen {ECO:0000256|ARBA:ARBA00023246};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 18..136
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 225..328
FT /note="Platelet-derived growth factor (PDGF) family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50278"
SQ SEQUENCE 336 AA; 39043 MW; 1EF1EBCC1696D77B CRC64;
MRKLVLMLPQ TDMYLYRRDE TIQVKGNGFV QSPRFPNSYP RNLLLTWRLH SQENTRIQLV
FDNQFGLEEA ENDICRYDFV EVEDISETST IIRGRWCGHK EVPPRIKSRT NQIKITFKSD
DYFVAKPGFK IYYSLVEDFQ PAAASETNWE SVTSSISGVS YNSPSVTDPT LIADALDKKI
AEFDTVEDLL KYFNPESWQE DLENMYLNTP RYRGRSYHDR KSKVDLDRLN DDAKRYSCTP
RNYSVNIREE LKLANVVFFP RCLLVQRCGG NCGCGTVNWR SCTCNSGKTV KKYHEVLQFE
PGHIKRKGRA KAMALVDIQL DHHERCDCIC SSRPPR
//
