ID A0A2K5TJL5_MACFA Unreviewed; 1061 AA.
AC A0A2K5TJL5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=SEC16 homolog B, endoplasmic reticulum export factor {ECO:0000313|Ensembl:ENSMFAP00000000227.2};
GN Name=SEC16B {ECO:0000313|Ensembl:ENSMFAP00000000227.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000000227.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000000227.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000000227.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the SEC16 family.
CC {ECO:0000256|ARBA:ARBA00005927}.
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DR AlphaFoldDB; A0A2K5TJL5; -.
DR STRING; 9541.ENSMFAP00000000226; -.
DR Ensembl; ENSMFAT00000028393.2; ENSMFAP00000000227.2; ENSMFAG00000040538.2.
DR VEuPathDB; HostDB:ENSMFAG00000040538; -.
DR GeneTree; ENSGT00940000160138; -.
DR OrthoDB; 1361743at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000040538; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0070971; C:endoplasmic reticulum exit site; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006914; P:autophagy; IEA:InterPro.
DR GO; GO:0048208; P:COPII vesicle coating; IEA:InterPro.
DR GO; GO:0007029; P:endoplasmic reticulum organization; IEA:Ensembl.
DR GO; GO:0016559; P:peroxisome fission; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0070863; P:positive regulation of protein exit from endoplasmic reticulum; IEA:Ensembl.
DR CDD; cd09233; ACE1-Sec16-like; 1.
DR Gene3D; 1.25.40.1030; -; 1.
DR InterPro; IPR024298; ACE1_Sec16_Sec31.
DR InterPro; IPR024880; Sec16.
DR PANTHER; PTHR13402:SF11; PROTEIN TRANSPORT PROTEIN SEC16B; 1.
DR PANTHER; PTHR13402; RGPR-RELATED; 1.
DR Pfam; PF12931; Sec16_C; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transport {ECO:0000256|ARBA:ARBA00022892}.
FT DOMAIN 447..681
FT /note="Ancestral coatomer element 1 Sec16/Sec31"
FT /evidence="ECO:0000259|Pfam:PF12931"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 833..1014
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..853
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 886..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1061 AA; 116810 MW; 94340EC8DBED68B2 CRC64;
MELWAPQRLP QTQGKVTTPS KDPDRGFRRD GHHRPVPHSR HNGERFHQWQ DNRGSPQPQQ
EPRTDHQQSH YASRPGDWHQ PLSRIDYYKS GYPSQLYSRP GYENSYQGYH SPTTREEYAY
GSYYYHGHPQ WLQEERVPRQ RSPYIWHEDY REQKYLDEHH YENQHSPFGT NSETHFQSNS
RNHYKDSPAS NSGQEWPGEL FPGSLLAGAQ KTKPSLASES NLLQQRESGL SSSSYELSQY
ITDAPERDDP PASAAWSPVQ AEDVSSAGPK APMKFYVPHA PVSFGPGGQL VCVGPSSPTD
GQAALVELHS MEVILNDSEE QEEMRSFSGP LIREDIHKVD IMTFCQQKAA QSCKSETLGS
RDSALLWQLL VLLCRQNGSM VGSDIAELLM QDCKKLEKYK RQPPVANLIS LTDEDWPVLS
SGTPNLLTGE IPPSVETPAQ IVEKFTRLLY YGRKKEALEW AMKNHLWGHA LFLSSKMDPR
TYSWVMSGFT STLALNDPLQ TLFQLMSGRI PQAATCCGEK QWGDWRPHLA VILSNQAGDP
ELYQRAIVAM GDTLAGKGLV EAAHFCYLMA HVPFGHYTVK TDHLVLLGSS HSQEFLKFAT
TEAIQRTEIF EYCQMLGRPK SFIPSFQVYK LLYASRLADY GLVSQALHYC EAIGAAVLSQ
GESSHPVLLA ELIKLAEKLK LSDPLVLERR SRDRDLEPDW LVQLRRQLEQ KIAGDTGDPH
LTRSDISGAR GTTTENTFYQ DFSGCQGYSE APEYRSALWL MLEQTCLPQP SPQQPFPLQP
GSYPAGGGAG QTGAPMPLYS VPEIHLPGTG SSVAVTEAPG GTVWEETLQT HLGPGENTVS
QETSQSPDGQ EVISKPQTPL AARAPSISES STNSAKEDEE ESSDEADKNS PQNTARRGKL
GDGKEHTKSS GFGWFSWFRS KPTKNASPSG EEDSSDSPDC ERETPRASSP HQAGLGLSLT
PSPDSPPLPA LSAFSVGTGG GEGQGSTSSG GAAAGAGVGG LSGPESVSFE LCSNPGVLLP
PPALKGAVPL YNPSQVPQLP MATSLNRPNR LAQRRYPTQP C
//
