ID A0A2K5TP56_MACFA Unreviewed; 624 AA.
AC A0A2K5TP56;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=G1 to S phase transition 2 {ECO:0000313|Ensembl:ENSMFAP00000001832.1};
GN Name=GSPT2 {ECO:0000313|Ensembl:ENSMFAP00000001832.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000001832.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000001832.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000001832.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR RefSeq; XP_005595584.1; XM_005595527.2.
DR AlphaFoldDB; A0A2K5TP56; -.
DR STRING; 9541.ENSMFAP00000001832; -.
DR Ensembl; ENSMFAT00000000374.2; ENSMFAP00000001832.1; ENSMFAG00000036045.2.
DR GeneID; 101866533; -.
DR KEGG; mcf:101866533; -.
DR CTD; 23708; -.
DR VEuPathDB; HostDB:ENSMFAG00000036045; -.
DR GeneTree; ENSGT00940000163245; -.
DR OMA; NDETCTG; -.
DR OrthoDB; 5477300at2759; -.
DR Proteomes; UP000233100; Chromosome X.
DR Bgee; ENSMFAG00000036045; Expressed in temporal lobe and 13 other cell types or tissues.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:Ensembl.
DR GO; GO:0003747; F:translation release factor activity; IEA:Ensembl.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03704; eRF3_C_III; 1.
DR CDD; cd04089; eRF3_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR009818; Ataxin-2_C.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF119; EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR GTP-BINDING SUBUNIT ERF3B; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR Pfam; PF07145; PAM2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 197..421
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..91
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68663 MW; 12007EA504875695 CRC64;
MDSGSSSSDS APDCWDQVDM EAPSGDGVSS AVAEAQREPL SSAFSRQLNV NAKPFVPNVH
AAEFVPSFLR GPTQPPTLPA GSGSNDETCT GAGYPQGKRM GRGAPVEPSR EEPLVSLEGS
NSAVTMELSE PVVENGEVEM ALEESWEHSK EVSEAEPGGG SSGDSGPPEE SGQEMMEEKE
EIRKSKYMIV PSGAPKKEHV NVVFIGHVDA GKSTIGGQIM FLTGMVDKRT LEKYEREAKE
KNRETWYLSW ALDTNQEERD KGKTVEVGRA YFETERKHFT ILDAPGHKSF VPNMIGGASQ
ADLAVLVISA RKGEFETGFE KGGQTREHAM LAKTAGVKHL IVLINKMDDP TVNWSIERYE
ECKEKLVPFL KKVGFSPKKD IHFMPCSGLT GANIKEQSDF CPWYTGLPFI PYLDNLPNFN
RSIDGPIRLP IVDKYKDMGT VVLGKLESGS IFKGQQLVMM PNKHNVEVLG ILSDDTETDF
VAPGENLKIR LKGIEEEEIL PGFILCDPSN LCHSGRTFDV QIVIIEHKSI ICPGYNAVLH
IHTCIEEVEI TALISLVDKK SGEKSKTRPR FVKQDQVCIA RLRTAGTICL ETFKDFPQMG
RFTLRDEGKT IAIGKVLKLV PEKD
//
