ID A0A2K5TR28_MACFA Unreviewed; 501 AA.
AC A0A2K5TR28;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Cyclic AMP-responsive element-binding protein 5 {ECO:0000256|PIRNR:PIRNR003153};
GN Name=CREB5 {ECO:0000313|Ensembl:ENSMFAP00000002526.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000002526.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000002526.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000002526.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the cAMP response element and activates
CC transcription. {ECO:0000256|PIRNR:PIRNR003153}.
CC -!- SUBUNIT: Binds DNA as a homodimer or as a heterodimer with JUN or
CC ATF2/CREBP1. {ECO:0000256|PIRNR:PIRNR003153}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR003153}.
CC -!- SIMILARITY: Belongs to the bZIP family.
CC {ECO:0000256|PIRNR:PIRNR003153}.
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DR RefSeq; XP_005549963.1; XM_005549906.2.
DR AlphaFoldDB; A0A2K5TR28; -.
DR Ensembl; ENSMFAT00000027672.2; ENSMFAP00000002526.2; ENSMFAG00000037539.2.
DR GeneID; 102123367; -.
DR KEGG; mcf:102123367; -.
DR CTD; 9586; -.
DR VEuPathDB; HostDB:ENSMFAG00000037539; -.
DR GeneTree; ENSGT00940000156420; -.
DR OrthoDB; 1361169at2759; -.
DR Proteomes; UP000233100; Chromosome 3.
DR Bgee; ENSMFAG00000037539; Expressed in heart and 8 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd14687; bZIP_ATF2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR016378; TF_CRE-BP1-typ.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR19304:SF8; CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 5; 1.
DR PANTHER; PTHR19304; CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN; 1.
DR Pfam; PF00170; bZIP_1; 1.
DR PIRSF; PIRSF003153; ATF2_CRE-BP1; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF57959; Leucine zipper domain; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|PIRNR:PIRNR003153};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|PIRNR:PIRNR003153};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR003153};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transcription {ECO:0000256|PIRNR:PIRNR003153};
KW Transcription regulation {ECO:0000256|PIRNR:PIRNR003153};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 9..33
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 368..431
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 258..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 442..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 393..427
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 285..319
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 325..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 501 AA; 56010 MW; 994DBA946AD8A5A7 CRC64;
MNLEQERPFV CSAPGCSQRF PTEDHLMIHR HKHEMTLKFP SIKTDNMLSD QTPTPTRFLK
NCEEVGLFSE LDCSLEHEFR KAQEEESSKR NISMHNAVGG AMTGPGTHQL SSARLPNHDT
SVVIQQAMPS PQSSSVITQA PSTNRQIGPV PGSLSSLLHL HNRQRQPMPA SMPGTLPNPT
MPGSSAVLMP MERQMSVNSS IMGMQGPNLS NPCASPQVQP MHSEAKMRLK AALTHHPAAM
SNGNMNTMGH MMEMMGSRQD QTPHHHMHSH PHQHQTLPPH HPYPHQHQHP AHHPHPQPHH
QQNHPHHHSH SHLHAHPAHH QTSPHPPLHT GNQAQVSPAT QQMQPTQTIQ PPQPTGGRRR
RVVDEDPDER RRKFLERNRA AATRCRQKRK VWVMSLEKKA EELTQTNMQL QNEVSMLKNE
VAQLKQLLLT HKDCPITAMQ KESQGYLSPE SSPPASPVPA CSQQQVIQHN TITTSSSVSE
VVGSSTLSQL TTHRTDLNPI L
//