ID A0A2K5TRD0_MACFA Unreviewed; 690 AA.
AC A0A2K5TRD0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Mbt domain containing 1 {ECO:0000313|Ensembl:ENSMFAP00000002609.2};
GN Name=MBTD1 {ECO:0000313|Ensembl:ENSMFAP00000002609.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000002609.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000002609.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000002609.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_015293780.1; XM_015438294.1.
DR AlphaFoldDB; A0A2K5TRD0; -.
DR SMR; A0A2K5TRD0; -.
DR Ensembl; ENSMFAT00000027756.2; ENSMFAP00000002609.2; ENSMFAG00000042808.2.
DR GeneID; 102127049; -.
DR CTD; 54799; -.
DR VEuPathDB; HostDB:ENSMFAG00000042808; -.
DR GeneTree; ENSGT00940000153840; -.
DR Proteomes; UP000233100; Chromosome 16.
DR Bgee; ENSMFAG00000042808; Expressed in thymus and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd20120; MBT_MBTD1_rpt1; 1.
DR CDD; cd20123; MBT_MBTD1_rpt2; 1.
DR CDD; cd20126; MBT_MBTD1_rpt3; 1.
DR CDD; cd20129; MBT_MBTD1_rpt4; 1.
DR Gene3D; 2.30.30.140; -; 4.
DR Gene3D; 3.30.60.160; -; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247:SF79; MBT DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR Pfam; PF02820; MBT; 4.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00561; MBT; 4.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 4.
DR PROSITE; PS51079; MBT; 4.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..690
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030050459"
FT DOMAIN 107..142
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT REPEAT 203..307
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 315..411
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 413..518
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 526..622
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REGION 44..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 622..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 668..690
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 77692 MW; 53E1C917F3142EEB CRC64;
MKLLLFLLTL TSGFNTSSNA LSTSRLGTVL GVRSLQRVPR WKRVRRTEHS SRSERKRRDS
FGMFDGYDSC SEDTSSSSSS EESEEEVAPL PSNLPIIKNN GQVYTYPDGK SGMATCEMCG
MVGVRDAFYS KTKRFCSVSC SRSYSSNSKK ASILARLQGK PPTKKAKVLQ KQPLVAKLAA
YAQYQATLQN QAKTKAAVSM EGFSWGNYIN SNSFIAAPVT CFKHAPMGTC WGDISENVRL
EVPNTDCSLP TKVFWIAGIV KLAGYNALLR YEGFENDSGL DFWCNICGSD IHPVGWCAAS
GKPLVPPRTI QHKYTNWKAF LVKRLTGAKT LPPDFSQKVS ESMQYPFKPC MRVEVVDKRH
LCRTRVAVVE SVIGGRLRLV YEESEDRTDD FWCHMHSPLI HHIGWSRSIG HRFKRSDITK
KQDGHFDTPP HLFAKVKEVD QSGEWFKEGM KLEAIDPLNL STICVATIRK VLADGFLMIG
IDGSEAADGS DWFCYHATSP SIFPVGFCEI NMIELTPPRG YTKLPFKWFD YLRETGSIAA
PVKLFNKDVP NHGFRVGMKL EAVDLMEPRL ICVATVTRII HRLLRIHFDG WEEEYDQWVD
CESPDLYPVG WCQLTGYQLQ PPASQSSREN QSASSKQKKK AKSQQYKGHK KMTTLQLKEE
LLDGEDYNFL QGASDQESNG SANFYIKQEP
//
