ID A0A2K5TUG5_MACFA Unreviewed; 1213 AA.
AC A0A2K5TUG5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Tau tubulin kinase 2 {ECO:0000313|Ensembl:ENSMFAP00000003717.2};
GN Name=TTBK2 {ECO:0000313|Ensembl:ENSMFAP00000003717.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000003717.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000003717.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000003717.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5TUG5; -.
DR STRING; 9541.ENSMFAP00000003717; -.
DR Ensembl; ENSMFAT00000022378.2; ENSMFAP00000003717.2; ENSMFAG00000001520.2.
DR VEuPathDB; HostDB:ENSMFAG00000001520; -.
DR GeneTree; ENSGT00940000160367; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000001520; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR PANTHER; PTHR11909; CASEIN KINASE-RELATED; 1.
DR PANTHER; PTHR11909:SF451; TAU-TUBULIN KINASE 2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 21..321
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 643..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1057
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1085..1213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1043
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1085..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1117
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1119..1140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1153..1181
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 50
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1213 AA; 133556 MW; 97FF3AEC99F096BD CRC64;
MSGGGEQPDI LSVGILVKER WKVLRKIGGG GFGEIYDALD MLTRENVALK VESAQQPKQV
LKMEVAVLKK LQGKDHVCRF IGCGRNDRFN YVVMQLQGRN LADLRRSQSR GTFTISTTLR
LGRQILESIE SIHSVGFLHR DIKPSNFAMG RFPSTCRKCY MLDFGLARQF TNSCGDVRPP
RAVAGFRGTV RYASINAHRN REQVGSIKER YDHRLMLKHL PPEFSIFLDH ISSLDYFTKP
DYQLLTSVFD NSIKTFGVIE SDPFDWEKTG NDGSLTTTTT STTPQLHTRL TPAAIGIANA
TPIPGDLLRE NTDEVFPDEQ LSDGENGIPV GVSPDKLPGS LGHPRPQEKD VWEEMDANKN
KIKLGICKAA TEEENSHGQA NGLLNAPSLG SPIRVRSEIT QPDRDIPLVR KLRSIHSFEL
EKRLTLEPKP DTDKFLETCL EKMQKDTTAG KESILPALLH KPCVPAVSRT DHIWHYDEEY
LPDVSKPASA NTPEQADGGG SNGFIAVNLS SCKQEIDSKE WVIVDKEQDL QDFRTNEAVG
HKTTGSPSDE EPEVLQVLEA SPQDEKLQLG PWAENDHLKK ETSGVVLALS AEGPPTAASE
QYTDRLELQP GAASQFIAAT PTSLMEAQAE GPLTAITIPR PSVASTQSTS GSFHYGQQPE
KKDLQPMEPT VELYSPRENF SGLAVTEGEP PSGGSRTDLG LQIDHIGHDV LPNIRESDKS
QDLGPKELPD RNRLVVREFE NLPGETEEKS ILLESDNEDE KLSRGQHCME ISSLPGDLVI
VEKDHSATTE PLHVTKTQTF SVVPNQDKNN EIIKLLTVGT SEISPRDIDP HVEGQIGQVA
EIQKNKVSKD DDIMSEDLPG HQGDLSTFLH QEGKREKIAP RNGELFHCVS ENEHGAPTRK
DMVRSSFVTR HSRIPVLAQE IDSTLESSSS VSAKEKLLQK KAYQPDLVKL LVEKRQFKSF
LGDLSSASDK LLEEKLATVP ATFCEEEVLT PFSRLTVDSH LSRSAEDSFL SPIISQSRKS
KIPRPVSWVN TDQVNSSTSS QFFPRPPPGK PPTRPGVEAR LRRYKVLGSS NSDSDLFSRL
AQILQNGSQK PRSTTQSKSP GSPHNPKTPP KSPVVPRRSP SASPRSSSLP RTSSSSPSRA
GRPHHDQRSS SPHLGRSKSP PSHSGSSSSR RSCQQEHCKP SKNGLKGSGS LHHHSASTKT
PPGKSKPASK LSR
//
