ID A0A2K5TW30_MACFA Unreviewed; 2626 AA.
AC A0A2K5TW30;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=PDZ domain containing 2 {ECO:0000313|Ensembl:ENSMFAP00000004279.2};
GN Name=PDZD2 {ECO:0000313|Ensembl:ENSMFAP00000004279.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000004279.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000004279.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000004279.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMFAT00000022941.2; ENSMFAP00000004279.2; ENSMFAG00000001834.2.
DR VEuPathDB; HostDB:ENSMFAG00000001834; -.
DR GeneTree; ENSGT00940000157749; -.
DR Proteomes; UP000233100; Chromosome 6.
DR Bgee; ENSMFAG00000001834; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR11324; IL16-RELATED; 1.
DR PANTHER; PTHR11324:SF16; PDZ DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00595; PDZ; 4.
DR SMART; SM00228; PDZ; 4.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR PROSITE; PS50106; PDZ; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 160..245
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 412..498
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 554..624
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 2450..2522
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 1..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 658..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 707..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1354..1444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1836..1911
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1964..2039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2058..2099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2184..2313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2536..2586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..286
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1235
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1264..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1354..1392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1636..1652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1658..1672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1742..1758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1774..1799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1860..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..1984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2023
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2187..2209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2223..2265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2279..2311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2626 AA; 277903 MW; 65B00D2CB740B668 CRC64;
MLRRFKHKAH STYNGNSSNS SEPGEAPTLE LGDRTAKKGK RTRKFGVISR PPANKAPEES
KGRIGCEVSS DPSTELENGP DPELGNGHVF QLENGPDSLK EVAGPHLERS EVDRGTEHRI
PKTDAPLTTS NDKRRFSKGG KTDFQSSDCL AREEVGRIWK MELLKESDGL GIQVSGGRGS
KRSPHAIVVT QVKEGGAAHR DGRLSLGDEL LVINGHLLVG LSHEEAVAIL RSATGMVQLV
VASKENSAED LLRLTSKSLP DLTSSVEDVS SWTDNEDQEA DGEEDEGTGS SVQRAMPGTD
EPQDVCGAEE SKGNLESPKQ GSNKIKLKSR LSGGVHRLES VEEYNELMVR NGDPRIRILE
VSRDGRKHSL PQLLDSSSAS QEYHIVKKST RSLSTTQVES PWRLIRPSVI SIIGLYKEKG
KGLGFSIAGG RDCIRGQMGI FVKTIFPNGS AAEDGRLKEG DEILDVNGIP IKGLTFQEAI
HTFKQIRSGL FVLTVRTKLV SPSLTPCSTP THMSRSASPS FNTSGGASAG GSDEGSTSSL
GRKTPGPKDR IVMEVTLNKE PRVGLGIGAC CLALENSPPG IYIHSLAPGS VAKMESNLSR
GDQILEVNSV NVRHAALSKV HAILSKCPPG PVRLVIGRHP NPKVSEQEMD EVIARSTYQE
SKEANSSPGL GTPLKSPSLA KKDSLISESE LSQYFAHDVP GPLSDFMVAG SEDEDHPGSG
CSTSEEGSLP PSTSTHKEPG KARANSLVTL GSQRASGLFH KQVTVARQTS LPGSPQALRN
PLLRQRKVGC YDANDASDEE EFDGEGDCIS LPGALPAPSR PLAEDNSRCV LISSSKGVDV
HNQEGRPQKT LVSKAISAPL LGSSVDLEES IPEGMVDTPS HAANLTASAR APKGSPGSWW
KKELTGSSSA PKLEYTVHTD TQSPMNTGSP GSPQQKNAGL GSRHRPVARV SPHCKRSEAE
ARPSGSETVN LTGRANDPCD VDSRVQATSV KVTVTGFRPG GAMEKESLGK LTTGDACVPT
NCELASALSH PDTSHLTENL PEAAPELGQQ PMTGLDSSSD LISSPGKKGA AYPDPSKTSV
DTGRVSRPEN PSQSASPKVA KYKARSPVRL PHEGSPSLGE KAVAPPDRSK TRSASETSTP
HNTRRAAFLR GAGPGAEGVT AAGAVLPGDP LTSQEQRQGA PGNHSKALEM TGTRAPESSQ
EPSLLEGADS VSSKAPQASL SLLPSTDNTT AACGRVSGQC CPAGSGESPV TDIDSFIKEL
DVSAARSPSS QTGDSGCQEG SAQGRPPAGA GGGSSCRAEP VTGGQTSSPR RAWAAGAPPH
PQWASQPSVL DSVNPDKHFT VNKNFLSNYS RNFSSFHEDS TSLSGLGDST EPSLSSMYGD
AEDSSSDPES LTEAPRASAR DGWSPPRSRV SSHKEDPSES EEEQIEICST NGCPNPPSSP
AHVPTQAAIC PASAKVLSLK YSTPRESVAS PREKAACLPA SYTSGPNSSQ PSSLLEVSSQ
EHETHVNISA SQNHRPSCAE ETTEVTSASS AMENSQLSKV ARHFHSAPII LSSPNMVNGL
ARDMLDDETL NQYETSINAA ASLSSFSVDV PKNGESALEN LHISESQDLD DLLQKPKMMG
RRPIMAWFKE INKHNQGTHL KSKTEKEQPL MAVRSPDSKI QIVSSSQKKG VAVPPSPPQP
KTNLENKDLS KKSPAEMLPT NGQKPKCGPK LKRLSLKGKA KVSSEAPAAN AVKAGGTDHR
KPLISPQTSH QTLSKVVSQR LHAADREDPD RNTTAAPRSP QCVLDSKPPL ATSGSLKPSV
SDTSIRMFVS PLTSPKPPPE QGVWSRFHVA VLSEPDRGCP ATPKSPKCGA EGRAPRADSG
PVSSTASRNG VSVAGNRQSE QHLASHMDSA ADTAQPRPTG EKGGSIVASD RLERTNQLKI
VEISAETVPK TVCGNRPAES DRQGGCLAQG NCQEKSEIRL CRQVTESSTS HPSSLPSHAP
QAEQEMSRSF GVAKLVSSSS SPQMPIRKAD SSQGKSSLMS DSLGVPRSGI LGGPSGEDHL
YFTPRPATRT YSMPAQFSSH FGRESHPPHS LGRSPRDSHV PVTSSVVPEA KASRGGLPSL
ADGQGVYSVK PLLETSRNLP ATDEGDIISV QETSCLVTDK IKVTRRHYCY EQNWPHESTS
FFSVKQRIKS FENLANADRP VAKSGVSPFL SVSSKPPIGR RSSGSIVSGS LGHPGDAAAR
SLRRSLSSCS ENQSEAGTLL PQMAKSPSSM TLTISRQNPP ETSSKGSDSE LKKSLGPLGI
PTPTTTPASP VKRNKSSVRH TQPSPVSRSK LQELRALSMP DLDKLCSEDY SAGPSAVLFK
TELEITPRRS PGPAGGVSCP EKAGNRACLG GSGPKTSAAE TPSSASEVGE AAQDLPFRRS
WSVTLDQLLV SAGDQQRLQS VLSSVGSKST ILTLIQEAKA QSENKEDVCF IVLNRKEGSG
LGFSVAGGTD VEPKSITVHR VFSQGAASQE GTMNRGDFLL SVNGASLAGL AHGNVLKVLH
QAQLHKDALV VIKKGMDQPR PSARQEPPTA NGKGLLSRKT IPLEPAVGEK RGKGSQTPGS
MTSQPWALHT TLRNPGKRHQ LSPDLPGMSF PMTQKFLLSI LLTYQK
//
