ID   A0A2K5TW72_MACFA        Unreviewed;      1044 AA.
AC   A0A2K5TW72;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=NLR family pyrin domain containing 13 {ECO:0000313|Ensembl:ENSMFAP00000004329.2};
GN   Name=NLRP13 {ECO:0000313|Ensembl:ENSMFAP00000004329.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000004329.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000004329.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000004329.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   AlphaFoldDB; A0A2K5TW72; -.
DR   STRING; 9541.ENSMFAP00000004329; -.
DR   Ensembl; ENSMFAT00000022991.2; ENSMFAP00000004329.2; ENSMFAG00000001862.2.
DR   VEuPathDB; HostDB:ENSMFAG00000001862; -.
DR   GeneTree; ENSGT00940000163591; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF16; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 13; 1.
DR   Pfam; PF13516; LRR_6; 5.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 10.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          1..107
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          229..364
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          132..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1044 AA;  118701 MW;  40C42EB8B842AE3E CRC64;
     MSFSVTTWAD SGTNQGLLPY LVALDQYQLE EFKLCLEPQQ LMDFWSAPQG HFPHIPWANL
     RAADPFNLSF LLEEHFPNGQ AWKVVLGVFQ TMNLTSLCEE VRAKMKGNVQ TQELQGPTQE
     DVEMLEAAAG NMQTQGCQDP NQEEPEEPEE ETGNVQVQGC QDLNQEEPEM LEEADHRRKY
     REKMTAKILE TWDNIDWPKD HVYIRNTSEG EHEELQRLLD PKRTRTQAQT IVVVGRAGVG
     KTTLAMQAML HWANGVLFQE KFSYVFFLSC HKIRYMKETS FAELISLDWP DSDAPIEEFM
     SQPEKLLFII DGFEEIIISE PSSESLNDGS PCTDWYQELP VTKILLSLVK KELVPLATLL
     ITIKNCFVID LKPSLVNPCF VQITGFTEED LWVYFMRHFE DSREVEKILQ QIRKNENLFH
     SCSAPMVCWT VCSCLKQSKV RYYDLQSITQ TTTSLYAYFF SNLFSTAEVD LADESWPGQW
     RALCNLAMEG LWSINFTFDR EDTELEGLEV PFIDCLYKFN IIQKGNDCRG CITFTHLSFQ
     EFFAAMSFVL EEPRELLPHS TKPQEMKILL RDVLLNKEAY WTPVVLFFFG LFKKNLAREL
     EDTLHCKMSP RVMEELLKWG EELGKAESAS LQFHVLQLFH CLHESQEEDL AKKMLGHIFE
     VDLNIPGDEE LQASSFCLKH CKRLNKLRLS VSSHILERDL EILETSEVDS RMHAWNSICS
     TLVTNENLHE LDLSNSKLHA SSVKGLCLAL KNPRCKVQKL TCKSVTPECV LQDLILVLQG
     NSKLTHLNFS SNKLGATVPL ILKALKHSAC NLKYLCLEKC SLSAASCQDL ALFLTSIQHI
     TRLCLGFNQL QDDGIKLLCA ALTHPKCALE RLELWFCQLG APSCRYLSDA LLQNRSLAHL
     NLSKNRLGDE GVKFLCEALG RPDCNLQSLN LSGCSFTREG CRELANALKH NHNVKILDLG
     QNDLQDDGVK LLCEALKPSH RALHTLGLAK CNVTTACCQH LSSVLSSSKS LVNLNLLVNE
     LDHDGVKMLC KALRKSTCRL QKLG
//