ID A0A2K5TX05_MACFA Unreviewed; 954 AA.
AC A0A2K5TX05;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit {ECO:0000256|ARBA:ARBA00015782};
DE EC=2.4.1.255 {ECO:0000256|ARBA:ARBA00011970};
DE AltName: Full=O-GlcNAc transferase subunit p110 {ECO:0000256|ARBA:ARBA00029769};
DE AltName: Full=O-linked N-acetylglucosamine transferase 110 kDa subunit {ECO:0000256|ARBA:ARBA00031470};
GN Name=OGT {ECO:0000313|Ensembl:ENSMFAP00000004612.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000004612.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000004612.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000004612.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 41 family. O-GlcNAc
CC transferase subfamily. {ECO:0000256|ARBA:ARBA00005386}.
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DR AlphaFoldDB; A0A2K5TX05; -.
DR Ensembl; ENSMFAT00000023278.2; ENSMFAP00000004612.2; ENSMFAG00000001803.2.
DR VEuPathDB; HostDB:ENSMFAG00000001803; -.
DR GeneTree; ENSGT00940000155085; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000233100; Chromosome X.
DR Bgee; ENSMFAG00000001803; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0097363; F:protein O-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.720.150; -; 1.
DR Gene3D; 3.40.50.11380; -; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR029489; OGT/SEC/SPY_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44366; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT; 1.
DR PANTHER; PTHR44366:SF1; UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT; 1.
DR Pfam; PF13844; Glyco_transf_41; 1.
DR Pfam; PF00515; TPR_1; 1.
DR Pfam; PF13414; TPR_11; 3.
DR Pfam; PF13432; TPR_16; 1.
DR SMART; SM00028; TPR; 9.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 7.
DR PROSITE; PS50293; TPR_REGION; 5.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}; Transferase {ECO:0000256|ARBA:ARBA00022676}.
FT REPEAT 89..122
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 123..156
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 157..190
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 235..268
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 269..302
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 303..336
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 337..370
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 384..924
FT /note="O-GlcNAc transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13844"
SQ SEQUENCE 954 AA; 106766 MW; A47CF99637ABA346 CRC64;
MASSVGNVAD STEPTKRMLS FQGLAELAHR EYQAGDFEAA ERHCMQLWRQ EPDNTGVLLL
LSSIHFQCRR LDRSAHFSTL AIKQNPLLAE AYSNLGNVYK ERGQLQEAIE HYRHALRLKP
DFIDGYINLA AALVAAGDME GAVQAYVSAL QYNPDLYCVR SDLGNLLKAL GRLEEAKACY
LKAIETQPNF AVAWSNLGCV FNAQGEIWLA IHHFEKVAEA EDCYNTALRL CPTHADSLNN
LANIKREQGN IEEAVRLYRK ALEVFPEFAA AHSNLASVLQ QQGKLQEALM HYKEAIRISP
TFADAYSNMG NTLKEMQDVQ GALQCYTRAI QINPAFADAH SNLASIHKDS GNIPEAIASY
RTALKLKPDF PDAYCNLAHC LQIVCDWTDY DERMKKLVSI VADQLEKNRL PSVHPHHSML
YPLSHGFRKA IAERHGNLCL DKINVLHKPP YEHPKDLKLS DGRLRVGYVS SDFGNHPTSH
LMQSIPGMHN PDKFEVFCYA LSPDDGTNFR VKVMAEANHF IDLSQIPCNG KAADRIHQDG
IHILVNMNGY TKGARNELFA LRPAPIQAMW LGYPGTSGAL FMDYIITDQE TSPAEVAEQY
SEKLAYMPHT FFIGDHANMF PHLKKKAVID FKSNGHIYDN RIVLNGIDLK AFLDSLPDVK
IVKMKCPDGG DNADSSNTAL NMPVIPMNTI AEAVIEMINR GQIQITINGF SISNGLATTQ
INNKAATGEE VPRTIIVTTR SQYGLPEDAI VYCNFNQLYK IDPSTLQMWA NILKRVPNSV
LWLLRFPAVG EPNIQQYAQN MGLPQNRIIF SPVAPKEEHV RRGQLADVCL DTPLCNGHTT
GMDVLWAGTP MVTMPGETLA SRVAASQLTC LGCLELIAKN RQEYEDIAVK LGTDLEYLKK
IRGKVWKQRI SSPLFNTKQY TMELERLYLQ MWEHYAAGNK PDHMIKPVEV TESA
//
