ID A0A2K5TX18_MACFA Unreviewed; 410 AA.
AC A0A2K5TX18;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Eomesodermin {ECO:0000313|Ensembl:ENSMFAP00000004608.2};
GN Name=EOMES {ECO:0000313|Ensembl:ENSMFAP00000004608.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000004608.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000004608.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000004608.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00201}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00201}.
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DR RefSeq; XP_015300502.1; XM_015445016.1.
DR AlphaFoldDB; A0A2K5TX18; -.
DR SMR; A0A2K5TX18; -.
DR STRING; 9541.ENSMFAP00000004608; -.
DR Ensembl; ENSMFAT00000023274.2; ENSMFAP00000004608.2; ENSMFAG00000002012.2.
DR GeneID; 102144498; -.
DR CTD; 8320; -.
DR VEuPathDB; HostDB:ENSMFAG00000002012; -.
DR GeneTree; ENSGT00940000158728; -.
DR OrthoDB; 5323209at2759; -.
DR Proteomes; UP000233100; Chromosome 2.
DR Bgee; ENSMFAG00000002012; Expressed in spleen and 5 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0002302; P:CD8-positive, alpha-beta T cell differentiation involved in immune response; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 2.60.40.820; Transcription factor, T-box; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032385; T-box_assoc.
DR InterPro; IPR046360; T-box_DNA-bd.
DR InterPro; IPR036960; T-box_sf.
DR InterPro; IPR001699; TF_T-box.
DR InterPro; IPR018186; TF_T-box_CS.
DR PANTHER; PTHR11267:SF13; EOMESODERMIN HOMOLOG; 1.
DR PANTHER; PTHR11267; T-BOX PROTEIN-RELATED; 1.
DR Pfam; PF00907; T-box; 1.
DR Pfam; PF16176; T-box_assoc; 1.
DR PRINTS; PR00937; TBOX.
DR SMART; SM00425; TBOX; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS01264; TBOX_2; 1.
DR PROSITE; PS50252; TBOX_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00201};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00201}; Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..161
FT /note="T-box"
FT /evidence="ECO:0000259|PROSITE:PS50252"
FT REGION 363..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 45983 MW; C554C4DCAC576159 CRC64;
MFPFLSFNIN GLNPTAHYNV FVEVVLADPN HWRFQGGKWV TCGKADNNMQ GNKMYVHPES
PNTGSHWMRQ EISFGKLKLT NNKGANNNNT QMIVLQSLHK YQPRLHIVEV TEDGVEDLNE
PSKTQTFTFS ETQFIAVTAY QNTDITQLKI DHNPFAKGFR DNYDSMYTAS ENDRLTPSPT
DSPRSHQIVP GGRYGVQSFF PEPFVNTLPQ ARYYNGERTV PQTNGLLSPQ QSEEVANPPQ
RWLVTPVQQP GTNKLDISSY ESEYTSSTLL PYGIKSLPLQ TSHALGYYPD PTFPAMAGWG
GRGSYQRKMA AGLPWTSRTS PTVFSEDQLS KEKVKEEIGS SWIETPPSIK SLDSNDSGVY
TSACKRRRLS PSNSSNENSP SIKCEDINAE EYSKDTSKGM GGYYAFYTTP
//
