ID A0A2K5TXT2_MACFA Unreviewed; 693 AA.
AC A0A2K5TXT2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Engulfment and cell motility 1 {ECO:0000313|Ensembl:ENSMFAP00000004883.2};
GN Name=ELMO1 {ECO:0000313|Ensembl:ENSMFAP00000004883.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000004883.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000004883.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000004883.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR AlphaFoldDB; A0A2K5TXT2; -.
DR STRING; 9541.ENSMFAP00000004883; -.
DR Ensembl; ENSMFAT00000023549.2; ENSMFAP00000004883.2; ENSMFAG00000002088.2.
DR VEuPathDB; HostDB:ENSMFAG00000002088; -.
DR GeneTree; ENSGT00940000155994; -.
DR OrthoDB; 4872856at2759; -.
DR Proteomes; UP000233100; Chromosome 3.
DR Bgee; ENSMFAG00000002088; Expressed in lymph node and 13 other cell types or tissues.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
DR CDD; cd13359; PH_ELMO1_CED-12; 1.
DR Gene3D; 6.10.250.810; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR PANTHER; PTHR12771:SF23; ENGULFMENT AND CELL MOTILITY PROTEIN 1; 1.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51335; ELMO; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 285..458
FT /note="ELMO"
FT /evidence="ECO:0000259|PROSITE:PS51335"
SQ SEQUENCE 693 AA; 80284 MW; 1D44D429FB48B4E1 CRC64;
MLIFLRWSLP NHEYYALQHA DSSNFYITEK NRNEIKNGTI LRLTKSPAQN AQQLHERIQS
SSMDAKLEAL KDLASLSRDV TFAQEFINLD GISLLTQMVE SGTERYQKLQ KIMKPCFGDM
LSFTLTAFVE LMDHGIVSWD TFSVAFIKKI ASFVNKSAID ISILQRSLAI LESMVLNSHD
LYQKVAQEIT IGQLIPHLQG SDQEIQTYTI AVINALFLKA PDDRRQEMAN ILAQKQLRSI
ILTHVIRAQR AINNEMAHQL YVLQVLTFNL LEDRMMTKMD PQDQAQRDII FELRRIAFDA
ESEPNNSSGS MEKRKSMYTR DYKKLGFINH VNPAMDFTQT PPGMLALDNM LYFAKHHQDA
YIRIVLENSS REDKHECPFG RSSIELTKML CEILKVGELP SETCNDFHPM FFTHDRSFEE
FFCICIQLLN KTWKEMRATS EDFNKVMQVV KEQVMRALTT KPSSLDQFKS KLQNLSYTEI
LKIRQSERMN QEDFQSRPIL ELKEKIQPEI LELIKQQRLN RLVEGTCFRK LNARRRQDKF
WYCRLSPNHK VLHYGDLEES PQGEVPHDSL QDKLPVADIK AVVTGKDCPH MKEKGALKQN
KEVLELAFSI LYDSNCQLNF IAPDKHEYCI WTDGLNALLG KDMMSDLTRN DLDTLLSMEI
KLRLLDLENI QIPDAPPPIP KEPSNYDFVY DCN
//
