ID   A0A2K5U398_MACFA        Unreviewed;       263 AA.
AC   A0A2K5U398;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE            Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
GN   Name=KCNMB3 {ECO:0000313|Ensembl:ENSMFAP00000006828.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000006828.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000006828.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000006828.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC       (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC       of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC       {ECO:0000256|RuleBase:RU368097}.
CC   -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC       of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC   -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC   -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC       {ECO:0000256|RuleBase:RU368097}.
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DR   AlphaFoldDB; A0A2K5U398; -.
DR   Ensembl; ENSMFAT00000025515.2; ENSMFAP00000006828.2; ENSMFAG00000000185.2.
DR   VEuPathDB; HostDB:ENSMFAG00000000185; -.
DR   GeneTree; ENSGT00950000183039; -.
DR   OrthoDB; 4267391at2759; -.
DR   Proteomes; UP000233100; Chromosome 2.
DR   Bgee; ENSMFAG00000000185; Expressed in lung and 13 other cell types or tissues.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR   PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR   PANTHER; PTHR10258:SF4; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-3; 1.
DR   Pfam; PF03185; CaKB; 1.
DR   PROSITE; PS00387; PPASE; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW   Ion channel {ECO:0000256|RuleBase:RU368097};
KW   Ion transport {ECO:0000256|RuleBase:RU368097};
KW   Membrane {ECO:0000256|RuleBase:RU368097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Transmembrane {ECO:0000256|RuleBase:RU368097};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW   Transport {ECO:0000256|RuleBase:RU368097}.
FT   TRANSMEM        36..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368097"
FT   TRANSMEM        187..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368097"
SQ   SEQUENCE   263 AA;  29909 MW;  6EDE27E92E959011 CRC64;
     MTAFPASGKK RETDYSDGDP LDVHKRLSSS AGEDRAVLLG FAMMGFSVLM FFLLGTTILK
     PFMLSAQREE STCTAIHTDI MDHWLDCTFT CGVHCRGQGK YPCLQVLVNL THSGQKALLH
     YNEEAVQINP KCFYTPKCHQ DRNDLLNSAL DIKEFFDHKN GTPFSCFYSP DSQSEDVILI
     KKYDQMAIFH CLFWPSLTLL GGALIVGMVR LTQHLSLLCE KYSTVVRDEV GGKLPYIGQH
     QFKLWSMRRS KGRSREILRL WPN
//