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Database: UniProt
Entry: A0A2K5U3L8_MACFA
LinkDB: A0A2K5U3L8_MACFA
Original site: A0A2K5U3L8_MACFA 
ID   A0A2K5U3L8_MACFA        Unreviewed;       584 AA.
AC   A0A2K5U3L8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 34.
DE   SubName: Full=Complement C8 alpha chain {ECO:0000313|Ensembl:ENSMFAP00000006952.2};
GN   Name=C8A {ECO:0000313|Ensembl:ENSMFAP00000006952.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000006952.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000006952.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000006952.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   AlphaFoldDB; A0A2K5U3L8; -.
DR   STRING; 9541.ENSMFAP00000006952; -.
DR   Ensembl; ENSMFAT00000025639.2; ENSMFAP00000006952.2; ENSMFAG00000036139.2.
DR   VEuPathDB; HostDB:ENSMFAG00000036139; -.
DR   GeneTree; ENSGT00940000160126; -.
DR   OrthoDB; 4572257at2759; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   Bgee; ENSMFAG00000036139; Expressed in liver.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR   GO; GO:0006957; P:complement activation, alternative pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 1.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR   Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR   InterPro; IPR048831; C8A_B_C6_EGF-like.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR001862; MAC_perforin.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   InterPro; IPR000884; TSP1_rpt.
DR   InterPro; IPR036383; TSP1_rpt_sf.
DR   PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR   PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR   Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR   Pfam; PF00057; Ldl_recept_a; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   Pfam; PF00090; TSP_1; 2.
DR   PRINTS; PR00764; COMPLEMENTC9.
DR   PRINTS; PR01705; TSP1REPEAT.
DR   SMART; SM00192; LDLa; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SMART; SM00209; TSP1; 2.
DR   SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR   SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
DR   PROSITE; PS50092; TSP1; 2.
PE   3: Inferred from homology;
KW   Complement alternate pathway {ECO:0000256|ARBA:ARBA00023162};
KW   Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Membrane {ECO:0000256|ARBA:ARBA00022452};
KW   Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022452};
KW   Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..584
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5030050721"
FT   DOMAIN          135..498
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   REGION          560..584
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        96..108
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        115..130
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   584 AA;  65389 MW;  950FA702D29CB898 CRC64;
     MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKRYRY
     RSLLQPNKFG GTICSGDVWD QASCSSSTPC IRQARCGQDF QCKETGRCLK RHLVCNGDQD
     CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA TYYGGQCETV
     YNGEWRELRY DPTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSELY DNANDLLSKV
     RKDKSDSFGV TIGIGPAGSP LMVGVGVSKS EDASFLKELN KYNEKKFIFM RIFTKVQTAH
     FKMRRDNIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGT YEYILVIDKA
     KMESLGITSR DIMTCFGGSL GIQYEGGINV DGGLSGDHCK KFGDGKTERA RKAMAVEDII
     SRVRGGSSGW SGGLAQNRST VTYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR
     QNLRHALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGHLGPACEQ IQTEGAKADG
     SWSCWSSWSV CRTGTQERRR ECDNPAPQNG GASCPGRKVQ TQAC
//
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