ID A0A2K5U5Z6_MACFA Unreviewed; 6669 AA.
AC A0A2K5U5Z6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Nebulin {ECO:0000313|Ensembl:ENSMFAP00000007773.1};
GN Name=NEB {ECO:0000313|Ensembl:ENSMFAP00000007773.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000007773.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000007773.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000007773.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMFAT00000026467.2; ENSMFAP00000007773.1; ENSMFAG00000000188.2.
DR VEuPathDB; HostDB:ENSMFAG00000000188; -.
DR GeneTree; ENSGT00940000154533; -.
DR Proteomes; UP000233100; Chromosome 12.
DR Bgee; ENSMFAG00000000188; Expressed in skeletal muscle tissue and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd11933; SH3_Nebulin_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013998; Nebulin-like.
DR InterPro; IPR000900; Nebulin_repeat.
DR InterPro; IPR035629; Nebulin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR11039; NEBULIN; 1.
DR PANTHER; PTHR11039:SF37; NEBULIN; 1.
DR Pfam; PF00880; Nebulin; 105.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00510; NEBULIN.
DR SMART; SM00227; NEBU; 181.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51216; NEBULIN; 132.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 6610..6669
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 34..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6529..6566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6583..6607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6529..6549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6669 AA; 772704 MW; 6868C16FECB9AE7E CRC64;
MADDEEYEEV VEYYTEEVVY EEVPGETITE IYETTTTRTS DYEQSETSKP ALAQPALAQP
APAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG RPYASTTDTP
ELRRIKKVQD QLSEVKYRID GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK
DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKTLFYP YNDSPELRRV AQAQKALSDV
AYKKGLAEQQ AQFTPLADPP EIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA
RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD
YNVLPASENP LLRQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK
KYKDSYLKNI LGHYVGSFED PYHSHCMRVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE
AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP
PDTPALIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD
YEKNKGKMIG ALSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ
LKNFSEAKYK DLYVKNILGH YVGSFEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ
TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDTPVLLQ AQLNTKQLSD LNYKAKHEGE
KFKCHVPADA PQFIQHRVNA YNLSDNLYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS
DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML
QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG
WVPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK
GEEIIHKYNL PADLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR
QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKTKYNTP
HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM
KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL
YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW HDLIAKGNNV LGDAIPITAA
KASRNIASDY KYKEAYEKAK GKHVGFRSLQ DDPKLVHYMN VAKMQSDREY KKNYENTKTS
YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDALS LEHTRNVNQI QSDNVYKDEY
NSFFKGIGWI PIGSLEVEKV KKAGDALNEK KYRQHPDTIK FTSLPDSMGM VLAQHNTKQL
SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP
IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF RSLQDDPKLV HYMNVAKMQS DREYKKGYEA
SKTKYHTPLD MVSVTAAKKS QEVATNANYR QPYHHYTLLP DALNVEHSRN AMQIQSDNLY
KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN
KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP
DAIAIKAARA SRDIASDYKY KQAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK
GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNLIHTY NMLPDAMSFE LAKTRMQIQS
DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL
AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY
DLRPDAIPIK AAKASRDIAS DYKYKHDYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR
EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN
RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM
DMVLAKQNAH TMNKYLYTVD WNKDKTNVHV MPDTPDILQA KQNQTLYSQK LYKLGWEESL
KKGYDLPVDA ISVQLAKASR DIASDFKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM
QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA
KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP
DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE
ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKDGYRKQLG HHIGARNIED DPKMMWSMHV
AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV
IHARQAYDLQ SDNLYKSDLQ WLKGIGWMPS GSLEDEKNKR ATQILSDHVY RQHPDKFKFS
SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL
GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IHDDPKMMWS
MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHEWTCLPDQ
SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VPIGSLDVEK CKRATEILSD KIYRQPPDTF
KFTSVTDSLE QVLAKNNALN MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR QNKINYSETL
YKLANEEAKK KGYDLRSDAI PIVAAKASRD IISDYKYKDG YRKQLGHHIG ARNIEDDPKM
MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHQWTCL
PDQNDVMHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSVD VVKCKRAAEI LSDNIYRQPP
DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQV HIMPDTPEIM LARQNKINYS
ENLYRQAMEE AKKEGYDLRS DAIPIVAAKA SRDIASDYKY KEAYRKQLGH HIGARAVHDD
PKIMWSLHIA KVQSDREYKK DFEKYKTRFS SPVDMLGIVL AKKCQTLVSD VDYKHPLHEW
ICLPDQNDII HARKAYDLQS DNLYKSDLEW MKGIGWVPID SLEVVRAKRA GELLSDTIYR
QRPETLKFTS ITDTPEQVLA KNNALNMNKR LYTEAWDNDK KTIHVMPDTP EIMLAKLNRI
NYSDKLYKLA LEESKKEGCD LRLDAIPIQA AKASREIASD YKYKEGYRKQ LGHHIGARNV
EDDPKMLWSI HAAKIQSDRE YKKDFEKWKT KFSSPVDMLG MVTAKKCQIL VSDIDYRHPL
HEWICLPDQN DVIQARKAYD LQSDAIYKSD LEWLRGIGWV PIGSVEVEKV KRAGEILSDR
KYRQPRDQLK FTCITDTPEI VLAKNNALTM SKHLYTEAWD ADKTSIHVMP DTPEILLAKS
NSANISQKLY TKGWDESKMK DYDLRADAIS IKSAKASRDI ASDYKYKEAY EKQKGHHIGA
QSIEDDPKIM CAIHAGKIQS EREYKKEFQK WKTKFSSPVD MLGILLAKKC QTLVSDIDYR
NYLHHWTCMP DQNDIIQAKK AYDLQSDALY KADLEWLRGI GWMPQGSPEV LRVKNAQEIL
CDSVYRTPVV NLKYTSIVDT PDVVLAKSNA ENISIPKYRE VWDKDKTSVH IMPDTPEINL
ARANALNVSN KLYREGWDEM KAGCDVRLDA IPIQAAKASR EIASDYKYKL DHEKQKGHYV
GTRTARDDNK IRWALIADKL QNEREYRLDW AKWKAKIQSP ADMLSVLHSK NSQALVSDVD
YRNYLHQWTC MPDQNDVIQA KKAYELQSDN VYKADLEWLR GIGWMPNDSV SVNHAKHAAD
IFSEKKYRTK IETLNFTPVD DRVDYVTAKQ SGEILDDIKY RKDWNDTKSK YTLTETPLLH
TAQEAARILD QYLYKEGWER QKATGYILPP DAVPFVHAHH SSDVQSELKY RADHVKQKGH
YVGVPTMRDD PKLVWFEHAG QIQNERLYKE DYHKTKAKIN IPADMKSVLA AKEGQTLVSD
IDYRNYLHQW TCHPDQNDVI QARKAYDLQS DNIYKADLEW LRGIGWIPLD SVDHVRVTKN
QEMMNQIKYK KNALDNYPNF TSVVDPPEIV LAKINSVNQS DVKYKETFNK AKGKYTFSPD
TPHISHSRDM GKLYSTILYK GAWEGTKAYG YTLDERYIPI VGAKHADLVN SELKYKETYE
KQKGHYLAGK VIGEFPGVVH CLDFQQMRSA LNYRKHYEDT KANVHIPNDM MNHVLAKKCQ
YILSDLEYRH YFHQWTSLPE EPNVIRVRNA QEILSDNVYK DDLNWLKGIG CYVWDTPQIL
HAKKSYDLQS QLQYTAAGKE NLQNYNLVTD TPVYVTAVQS GINASEVKYK ENYHQIKDKY
TTVLETVDSD RTRNLKNLYS SNLYKEAWDR VKATSYILPS STLSLTHAKN QKHLASHVKY
REEYEKFKAL YTLPRSVDDD PNTARCLRVG KLNIDRLYRS VYEKNKMKIH IVPDMVEMVT
AKDSQKKVSE IDYRLHLHEW ICHPDLKVND HVRKVTDQIS DIVYKDDLNW LKGIGCYVWD
TPEILHAKHA YDLRDDIKYK AHMLKTRNDY KLVTDTPVYV QAVKSGKQLS DAVYHYDYVH
SVRGKVAPTT KTVDLDRALH AYKLQSSNLY KTSLRTLPTG YRLPGDTPHF KHIKDTRYMS
SYFKYKEAYE HTKAYGYTLG PKDVPFVHVR RVNNVTSERL YRELYHKLKD KIHTTPDTPE
IRQVKKTQEA VSELIYKSDF FKMQGHMISL PYTPQVIHCR YVGDITSDIK YKEDLQVLKG
FGCFLYDTPD MVRSRHLRKL WSNYLYTDKA RKMRDKYKVV LDTPEYRKVQ ELKTHLSELV
YRAAGKKQKS IFTSVPDTPD LLRAKRGQKL QSQYLYVELA TKERPHHHAG NQTTALKHAK
DVKDMVSEKK YKIQYEKMKD KYTPVPDTPI LIRAKRAYWN ASDLRYKETF QKTKGKYHTV
KDALDIVYHR KVTDDISKIK YKENYMSQLG IWRSIPDRPE HFHHRAVTDA VSDVKYKEDL
TWLKGIGCYA YDTPDFTLAE KNKTLYSKYK YKEVFERTKS DFKYVADCPI NRHFKYATQL
MNEKKYRADY EQRKDKYHLV VDEPRHLLAK TAGDQISQIK YRKNYEKSKD KFTSIVDTPE
HLRTTKVNKQ ISDILYKLEY NKAKPRGYTT IHDTPMLLHV RKVKDEVSDL KYKEVYQRNK
SNCTIEPDAV HIKAAKDAYK VNTNLDYKKQ YEATKAHWKW TPDRPDFLQA AKSSLQQSDF
EYKLDREFLK GCKLSVTDDK NTVLALRNTL IESDLKYKEK HVKERGTCHA VPDTPQILLA
KTVSHLVSEN KYKDHVKKHL AQGSYTTLPE TRDTVHVKEV TKHVSDTNYK KKFVKEKGKS
NYSIMLEPPE VKHAMEVAKK QSDVAYRKDA KENLHYTTVA DRPDIKKATQ AAKQASEVEY
RAKHRKEGSH GLSMLGRPDI EMAKKAAKLS SQVKYRENFD KEKGKTPKYN PKDSQLYKVM
KDANNLASEV KYKADLKKLH KPVTDMKESL IMNHVLNTSQ LASSYQYKKK YEKSKGHYHT
IPDNLEQLHL KEATELQSIV KYKEKYEKER GKPMLDFETP TYITAKESQQ MQSGKEYRKD
YEESIKGRNL TGLEVTPALL HVKYATKIAS EKEYRKDLEE SIRGKGLTEM EDTPDMLRAK
NATQILNEKE YKRDLELEVK GRGLNAMANE TPDFMRARNA TDIASQIKYK QSAEMEKANF
TSVVDTPEII HAQQVKNLSS QKKYKEDAEK SMSYYETVLD TPEMQRVREN QKNFSLLQYQ
CDLKNSKGKI TVVQDTPEIL RVKENQKNFS SVLYKEDVSP GTAIGKTPEM MRVKQTQDHI
SSVKYKEAIG QGTPIPDLPE VKRVKETQKH ISSVMYKENL GTGIPTTVTP EIERVKRNQE
NFSSVLYKEN LGKGIPTAIT PEMERVKRNQ ENFSSVLYKE NMGKGTPLPV TPEMERVKHN
QENISSVLYK ENVGKATPTP VTPEMQRVKR NQENISSVLY KENLGKATPT PFTPELERVK
RNQENFSSVL YKENMRKATP TPVTPEMERA KRNQENISSV LYSDSFRKQI QGKAAYVLDT
PEMRRVRETQ RHISTVKYHE DFEKHKGCFT PVVTDPITER VKKNMQDFSD INYRGIQRKV
VEMEQKRNDQ DQETITGLRV WRTNPGSVFD YDPAEDNIQS RSLHMINVQA QRRSREQSRS
ASALSISGGE EKSEHSEAPD HHLSTYSDGG VFAVSTAYKH AKTTELPQQR SSSVATQQTT
VSSIPSHPST AGKIFRAMYD YMAADADEVS FKDGDAIINV QAIDEGWMYG TVQRTGRTGM
LPANYVEAI
//
