ID   A0A2K5U636_MACFA        Unreviewed;      1027 AA.
AC   A0A2K5U636;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=NLR family pyrin domain containing 8 {ECO:0000313|Ensembl:ENSMFAP00000007813.2};
GN   Name=NLRP8 {ECO:0000313|Ensembl:ENSMFAP00000007813.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000007813.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000007813.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000007813.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the NLRP family.
CC       {ECO:0000256|ARBA:ARBA00008665}.
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DR   AlphaFoldDB; A0A2K5U636; -.
DR   STRING; 9541.ENSMFAP00000007813; -.
DR   Ensembl; ENSMFAT00000026507.2; ENSMFAP00000007813.2; ENSMFAG00000040791.2.
DR   VEuPathDB; HostDB:ENSMFAG00000040791; -.
DR   GeneTree; ENSGT00940000163909; -.
DR   OrthoDB; 55870at2759; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   CDD; cd08320; Pyrin_NALPs; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR004020; DAPIN.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR041267; NLRP_HD2.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR   PANTHER; PTHR45690:SF8; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 8; 1.
DR   Pfam; PF13516; LRR_6; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17776; NLRC4_HD2; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   Pfam; PF02758; PYRIN; 1.
DR   SMART; SM00368; LRR_RI; 7.
DR   SMART; SM01289; PYRIN; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50824; DAPIN; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          41..123
FT                   /note="Pyrin"
FT                   /evidence="ECO:0000259|PROSITE:PS50824"
FT   DOMAIN          204..335
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1027 AA;  117272 MW;  137E58EEA6CA092F CRC64;
     MSDVNPPSDT PIPFSSSSTH SSCNPPWTFS CYPGSPCENG VMLYMRYVSN KELQWFKQFL
     LNELRAGTTP ITWDQVKRAS WAEVVHLLIE RFPGRRAWDV TSNIFALMNR DKMCALVHRE
     INAILPTLEP EDLNVGETEV NLEEGESDKI QQYKLNVIVK CFPTWDFMTW PGNQRDFFYQ
     DVHRHMEYLP CLLLPKRPRG RQPKTVVIQG VPGIGKTTLA KTVMLEWASN RFYAHKPWCA
     FYFHCQEMNQ TTEHSFSELI EHKWPGSQDL VAKIMSKPDQ LLLLLDGFEE LTSTLINRPE
     DLSEDWRQKL PGSVLLSSLL SKRMLPEATL LIMIRCTSWP TCKPLLKRPS LVTLPGFNTT
     EKIKYFQMYF GYGETDRVLS FAMENTVLFS MCQVPVVCWM VCSGLKQQME RGNNLTQACP
     NATSVFVRYI SSLFPTRAEN FSRKIHQAQL EGLCHLAADG MWHRQWVFGK EDLEEAKLDQ
     MGVAAFLGMS VLRRIAGEED RYTFTLLIFQ EFFAALFYVL CFPQRLQNFH VLSHMNIQRL
     IASPRGSKSY LSHMGLFLFG FLNGTCALAV EQSFRCKVSF NNKRKLLKVI PLLQKCEPPS
     PCSGVPQLFY CLHEIREEAF VSQALNGYHK AVLKIGNSKD VQVSAFCLKR CEHLQEVELT
     VTLNLKNVWK LSSGSRPGSE APESKELHCW WQDLCSVFAT NDKLEVLTLT NSALGPPFLK
     ALAAALKHPQ CKLQKLLLRR VNSTMLNQDL IGVLMGNEHL RYLEIQHVEV ESNVVKLLCK
     ALRSPRCRLQ CLRLEDCLAT PRIWTDLGSN LQVNRHLKTL ILTKNSLENC GACYLSVAQL
     ERLSIENCNL TQLSCESLAS CLRKSKMLTH LSLAENALKD EGVKHIWNAL SHLRCPLQRL
     VLRKCDLTFN CCQDMISALC KNKTLKSLDL SFNSLKDDGV ILLCEALKNP DCTLQILELE
     NCLFTSICCQ AIASMLCKNQ HLRHLDLSKN VIEVDGILTL CEAFSSQKKR EEVILPAWAT
     WQNPIFY
//