ID A0A2K5U6G5_MACFA Unreviewed; 705 AA.
AC A0A2K5U6G5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Heterogeneous nuclear ribonucleoprotein U like 2 {ECO:0000313|Ensembl:ENSMFAP00000007914.2};
GN Name=HNRNPUL2 {ECO:0000313|Ensembl:ENSMFAP00000007914.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000007914.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000007914.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000007914.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K5U6G5; -.
DR STRING; 9541.ENSMFAP00000007914; -.
DR Ensembl; ENSMFAT00000026608.2; ENSMFAP00000007914.2; ENSMFAG00000041014.2.
DR VEuPathDB; HostDB:ENSMFAG00000041014; -.
DR GeneTree; ENSGT00940000160376; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000041014; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0045202; C:synapse; IEA:Ensembl.
DR CDD; cd12884; SPRY_hnRNP; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035778; SPRY_hnRNP_U.
DR PANTHER; PTHR12381; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U FAMILY MEMBER; 1.
DR PANTHER; PTHR12381:SF66; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN U-LIKE PROTEIN 2; 1.
DR Pfam; PF13671; AAA_33; 1.
DR Pfam; PF02037; SAP; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00513; SAP; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 3..37
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT DOMAIN 176..369
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 40..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..624
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 585..599
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 705 AA; 81302 MW; 0A0217BDC20EE324 CRC64;
MEVKRLKVTE LRSELQRRGL DSRGLKVDLA QRLQEALDAE MLEDEAGGGG AGARRGRGRG
ATPTQALGQA AAAEPDASEK PVETTVGSGG VNGGEEQGPG KGEEDEPEER SGDETPGSEV
PGDKAAEEQG DDQDSEKSKP AGSDGERRGV KRQRDEKDEH GRAYYEFREE AYHSRSKSPL
PPEEEAKDEE EDQTLVNLDT YTSDLHFQVS KDRYGGQPLF SEKFPTLWSG ARSTYGVTKG
KVCFEAKVTQ NLPMKEGCTE VSLLRVGWSV DFSRPQLGED EFSYGFDGRG LKAENGQFEE
FGQTFGENDV IGCFANFETE EVELSFSKNG EDLGVAFWIN KESLADRALL PHVLCKNCVV
ELNFGQKEEP FFPPPEEFVF IHAVPVEERV RTAVPPKTIE ECENVLKLDL INMTLTYLSL
YFWFCWALKY AKENPEKRYN VLGAETVLNQ MRMKGLEEPE MDPKSRDLLV QQASQCLSKL
VQIASRTKRN FILDQCNVYN SGQRRKLLLF KTFSRKVVVV VPNEEDWKKR LELRKEVEGD
DVPESIMLEM KANFSLPEKC DYMDEVTYGE LEKEEAQPIV TKYKEEARKL LPPSEKRTNR
RNNRNKRNRQ NRSRGQGYVG GQRRGYDNRA YGQQYWGQPG NRGGYRNFYD RYRGDYDRFY
GRDYEYNRYR DYYRQYNRDW QSYYYHHPQD RDRYYRNYYG YQGYR
//
