ID   A0A2K5U6H1_MACFA        Unreviewed;       158 AA.
AC   A0A2K5U6H1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=CD74 molecule {ECO:0000313|Ensembl:ENSMFAP00000007950.1};
GN   Name=CD74 {ECO:0000313|Ensembl:ENSMFAP00000007950.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000007950.1, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000007950.1, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000007950.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A2K5U6H1; -.
DR   Ensembl; ENSMFAT00000026645.2; ENSMFAP00000007950.1; ENSMFAG00000042836.2.
DR   VEuPathDB; HostDB:ENSMFAG00000042836; -.
DR   GeneTree; ENSGT00390000008961; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   Bgee; ENSMFAG00000042836; Expressed in spleen and 13 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0035718; F:macrophage migration inhibitory factor binding; IEA:InterPro.
DR   GO; GO:0042289; F:MHC class II protein binding; IEA:InterPro.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR043530; CD74_antigen.
DR   InterPro; IPR015386; MHC_II-assoc_invar/CLIP_MHC-bd.
DR   InterPro; IPR022339; MHC_II-assoc_invar_chain.
DR   PANTHER; PTHR14093; HLA CLASS II GAMMA CHAIN; 1.
DR   PANTHER; PTHR14093:SF17; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN GAMMA CHAIN; 1.
DR   Pfam; PF09307; MHC2-interact; 1.
DR   PIRSF; PIRSF001992; CD74_antigen; 1.
DR   PRINTS; PR01990; CD74ANTIGEN.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        48..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          17..122
FT                   /note="MHC class II-associated invariant chain/CLIP MHC II-
FT                   interacting"
FT                   /evidence="ECO:0000259|Pfam:PF09307"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   158 AA;  18064 MW;  503261C734C3C88D CRC64;
     MYRSSRRSCQ EDQKPVMDDQ RDLISNNEQL PMLGRRPGTP ESKCSRGALY TGFSILVTLL
     LAGQATTAYF LYQQQGRLDK LTVTTQSLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM
     GAQGPMQNAT KYGNMTEDHV MHLLQSHWNW RTRLLGWV
//