ID   A0A2K5U8P7_MACFA        Unreviewed;       894 AA.
AC   A0A2K5U8P7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Leptin receptor {ECO:0000256|ARBA:ARBA00019169};
DE   AltName: Full=OB receptor {ECO:0000256|ARBA:ARBA00031601};
GN   Name=LEPR {ECO:0000313|Ensembl:ENSMFAP00000008746.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000008746.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000008746.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000008746.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC       {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004251}. Lateral cell membrane
CC       {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC       subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR   RefSeq; XP_005543198.1; XM_005543141.2.
DR   RefSeq; XP_005543199.1; XM_005543142.2.
DR   AlphaFoldDB; A0A2K5U8P7; -.
DR   Ensembl; ENSMFAT00000021303.2; ENSMFAP00000008746.2; ENSMFAG00000001122.2.
DR   GeneID; 102115046; -.
DR   CTD; 3953; -.
DR   VEuPathDB; HostDB:ENSMFAG00000001122; -.
DR   GeneTree; ENSGT00730000111209; -.
DR   Proteomes; UP000233100; Chromosome 1.
DR   Bgee; ENSMFAG00000001122; Expressed in bone marrow and 11 other cell types or tissues.
DR   GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   CDD; cd00063; FN3; 3.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR   InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR010457; IgC2-like_lig-bd.
DR   InterPro; IPR041182; LEP-R_IGD.
DR   PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23036:SF89; INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1; 1.
DR   Pfam; PF06328; Lep_receptor_Ig; 1.
DR   Pfam; PF18589; ObR_Ig; 2.
DR   SMART; SM00060; FN3; 4.
DR   SUPFAM; SSF49265; Fibronectin type III; 4.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
DR   PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        838..861
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          237..331
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          537..632
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
FT   DOMAIN          738..831
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
SQ   SEQUENCE   894 AA;  102208 MW;  0FFE4ECF0B45A834 CRC64;
     MICQKFCVVL LHWEFICVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNL
     NGHYETAVEF NSSDTHFSNL SKTTFHCCFR SEQDRNCSLC ADNIEGKTFV STVNSSVFQQ
     MGANWNIQCW LKGDLKLFIC YVESLFKNPF KNYKHKVHLL YVLPEVLEDS PLVPQKGSFQ
     MVHCNCSVHE RCECLVPVPT AKLNDTLLMC LKITSGGVIF QSPLMSVQPI NMVKPDPPLG
     LRMEITDDGN LKISWSSPPL VPFPLQYEVK YSENSTTVIR EADKIVSATS LLVDGILPGS
     SYEVQVRGKR LDGPGIWSDW STPHVFTTQD VIYFPPKILT SVGSNVSFHC IYKNENKIVS
     SKKIVWWMNL AEKIPQSQYD VVSDHVSKVT FFNLNETKPR GKFTYDAVYC CNEHECHHRY
     AELYVIDVNI NISCETDGHL TKMTCRWSTN TIQSLAGSTL QLRYRRSSLY CFDIPSIHPI
     SKPKDCYLQS DGFYECVFQP IFLLSGYTMW IRINHPLGSL DSPPTCVLPD SVVKPLPPSS
     VKAEIIKNIG LLKISWEKPV FPENNLQFQI RYGLSGKEIQ WKMYDVYDAK SKSVSLPVPD
     FCAVYAVQVR CKRSDGLGLW SNWSNPAYTV VMDIKVPMRG PEFWRIINGD TMKKEKNVTL
     LWKPLMKNDS LCSVQRYVIN HHTSCNGTWS EDVGNHTKFT FLWTEQAHTV TVLAINSIGA
     SVANFNLTFS WPMSKVNIVQ SLSAYPLNSS CVILSWILSP SDYKLMYFII EWKNLNEDGE
     IKWLRISSSV KKYYIHDHFI PIEKYQFSLY PIFMEGVGKP KIINSFTQDN TEKHQNDAGL
     YVIVPVIISS SILLLGTLLI LHQRMKKLFW EDVPNPKNCS WAQGLNFQKR TDIL
//