ID A0A2K5U9R6_MACFA Unreviewed; 1260 AA.
AC A0A2K5U9R6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Laminin subunit gamma 2 {ECO:0000313|Ensembl:ENSMFAP00000009103.2};
GN Name=LAMC2 {ECO:0000313|Ensembl:ENSMFAP00000009103.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000009103.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000009103.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000009103.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; A0A2K5U9R6; -.
DR Ensembl; ENSMFAT00000020947.2; ENSMFAP00000009103.2; ENSMFAG00000000974.2.
DR VEuPathDB; HostDB:ENSMFAG00000000974; -.
DR GeneTree; ENSGT00940000160470; -.
DR OrthoDB; 90222at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000000974; Expressed in colon and 5 other cell types or tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR CDD; cd00055; EGF_Lam; 6.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF313; LAMININ SUBUNIT GAMMA-2; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 1.
DR Pfam; PF00053; Laminin_EGF; 7.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00180; EGF_Lam; 7.
DR SMART; SM00281; LamB; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 4.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 3.
DR PROSITE; PS51115; LAMININ_IVA; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}.
FT DOMAIN 151..197
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 206..253
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 280..448
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 584..639
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 22..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 680..733
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 880..914
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 952..979
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1106..1133
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 30..45
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 151..163
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 171..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 224..233
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 608..617
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1260 AA; 138662 MW; B813B952A6938ED1 CRC64;
MHQRRILRLV KGVDIAAEQG LSQVEESIKP PDQGKGRHSR AQSENQQPRR RAATPAAETE
TERPGPAMPA LWLGCCLCFS LLLPAARATS RREVCDCNGK SRQCIFDQEL YRQTGNGFRC
LNCNDNTDGI HCERCKDGFY RHRERDRCLP CNCNSKGSLS ARCDNSGRCS CKPGVTGARC
DRCLPGFHML TDAGCTQDQR LLDSKCDCDP AGIAGPCDAG RCVCKPAVTG ERCDRCRSGS
YNLDRGNPEG CTQCFCYGHS ASCRSSADYS VHKITSTFNQ DVDGWKAVQR NGSPAKLQWS
QRHQDVFSSA RRPDPVYFVA PAKFLGNQQV SYGQSLSFDY RVDRGGRHPS AHDVILEGAG
LRITAPLMPL GKTLPCGLTK TYTLRLNEHP SSNWSPQLSY FEYRRLLRNL TALRIRATYG
EYSTGYIDNV TLISARPVSG APAPWVEQCI CPVGYKGQFC QDCASGYKRD SAKLGPFGTC
IPCNCQGGGA CDPDTGDCYS GDENPDIECA DCPIGFYNDP HDPRSCKPCP CHNGFSCSVM
PETEEVVCNN CPPGVTGARC ELCADDYFGD PFGEHGPVRP CQPCQCNNNV DPSASGNCDR
LTGRCLKCIH NTAGIYCDQC KAGYFGDPLA TNPAEKCRAC NCNPMGSEPV ECRSDGTCVC
KPGFGGPNCE HGAFSCPACY NQVKIQMDQF MQQLQRMEAL ISKAQGGDGA VLDTELEGRM
QQAEQALRDI LRDAQISEGA SRSLGLQLAK VRSQENSYRS RLDDLKMTVE RVRALGSQYQ
NQVRDTHRLI TQMQLSLAES EASLGNTNIP ASDHYVGPNG FKSLAQEATR LAESHVESAS
NMEQLTKETE DYSKQALSLV HKALREGGGS GSGSLDGAVV QGVVEKLEKT KSLAQQLTRE
ATQAETEADR SYQHSLRLLD SVSQLQGVND QTFQVEEAKR IKQKADSLSS LVTRHMDEFK
RAQKNLGDWK EETQQLLQNG KNGREKSDQL LSRANLAKSR AQEALSMGNA TFYEVESILK
NLREFDLQVD NRKAEAEEAM KRLSYISQKV SDASDKTQQA ERALGSAAAD AQRAKNGARE
ALKISSEIEQ EIGSLNLEAN VTADGALAME KGLASLKSEM REVEGELERK ELEFDTNMDA
VQMVITEAQR VDTRAKNTGV TIQDTLNTLD GLLYLMDQPV SVDEEGLILL EQKLSRAKNQ
INSQLRPMMS ELEERARRQR GHLHLLETSI DGILADVKNL ENIRDNLPPG CYNTPVLEQQ
//
