ID A0A2K5UA58_MACFA Unreviewed; 1033 AA.
AC A0A2K5UA58;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Importin 4 {ECO:0000313|Ensembl:ENSMFAP00000009242.2};
GN Name=IPO4 {ECO:0000313|Ensembl:ENSMFAP00000009242.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000009242.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000009242.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000009242.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A2K5UA58; -.
DR Ensembl; ENSMFAT00000020805.2; ENSMFAP00000009242.2; ENSMFAG00000000743.2.
DR VEuPathDB; HostDB:ENSMFAG00000000743; -.
DR GeneTree; ENSGT00550000075074; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000000743; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR Pfam; PF13513; HEAT_EZ; 2.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1033
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5031034114"
FT DOMAIN 291..535
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 343..383
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 852..890
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1033 AA; 113175 MW; 2DDD204C261DD8BE CRC64;
MCPNLVKTLC PHLLKVSLLA APLCLATVCR GRYWRVIEEI SPVCRHCVSL SLAQLSATIF
RKEGLEAWPQ LLQLLQHSTH SPHSPEREMG LLLLSVVVTS RPEAFQPHHR ELLRLLNETL
GEVGSPGLLF YSLRTLTTMA PYLSTEDVPL SRMLVPKLIV AVQTLIPIDE AKACEALEVL
DELLESEVPI ITPYLSEVLT FCLEVARNVA LGNAIRVRVL CCLTFLVKVK SKALLKNRLL
PPLLHTLFPI MAAEPLPGQL DPEDQDSEEE ELEIELMGET PKHFAVQVVD MLALHLPPDK
LCPQLMPMLE EALRSESPYQ RKAGLLVLAV LSDGAGDHIR QRLLPPLLQI VCKGLEDPSQ
VVRNAALFAL GQFSENLQPH ISSYSREVMP LLLAYLKSVP LGHTHHLAKA CYALENFVEN
LGPKVQPYLP ELMECMLQPL RSPSSPRAKE LAVSAVGAIA TAAQASLLPY FPAIMEHLRE
FLLTGREDLQ PVQIQSLETL GVLARAVGEP MRPLAEECCQ LGLGLCNQVD DPDLRRCTYS
LFAALSGLMG EGLAPHLEQI TTLMLLSLRS TEGIVPQYDG SSSFLLFDDE SDGEEEEELM
DEDVEEEDDS EISGYSVENA FFDEKEDTCA ALGEISVNTS VAFLPYMESV FEEVFKLLEC
PHLNVRKAAH EALGQFCCAL HKACQSCPSE PNTAALQAAL ARVVPSYMHS VNRERERQVV
MAVLEALTGV LRSCGTLTLK PPGRLAELCS MLKAVLQRKT ACQDTDEEEE EEDDDQAEYD
AMLLEHAGEA IPALAAAAGG DSFAPFFAGF LPLLVCKTKQ GCTVAEKSFA VGTLAETIQG
LGAASAQFVS RLLPVLLSTA READPEVRSN AIFGLGVLAE HGGHPAQEHF PKLLGLLFPL
LARERHDRVR DNICGALARL LMASPTRKPE PQVLAALLHA LPLKKDLEEW VTIGRLFSFL
YQSSPDQVVD VAPELLRICS LILADNKIPP DTKAALLLLL TFLAKQHADS FQAALGSLPV
DKAQELQAVL GLS
//
