ID A0A2K5UF42_MACFA Unreviewed; 1164 AA.
AC A0A2K5UF42;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Polyhomeotic homolog 1 {ECO:0000313|Ensembl:ENSMFAP00000010982.2};
GN Name=PHC1 {ECO:0000313|Ensembl:ENSMFAP00000010982.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000010982.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000010982.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000010982.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K5UF42; -.
DR Ensembl; ENSMFAT00000045569.2; ENSMFAP00000010982.2; ENSMFAG00000007626.2.
DR VEuPathDB; HostDB:ENSMFAG00000007626; -.
DR GeneTree; ENSGT00940000156612; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000007626; Expressed in heart and 13 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd09577; SAM_Ph1_2_3; 1.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF20; POLYHOMEOTIC-LIKE PROTEIN 1; 1.
DR Pfam; PF16616; PHC2_SAM_assoc; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 951..985
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT DOMAIN 1100..1164
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 373..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 590..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 791..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1008..1089
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..667
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 719..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..813
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1008..1023
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1029..1046
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1164 AA; 122542 MW; F88363EB773B7085 CRC64;
MATGAGRKRG TRGREGRRAP REAEGRGRGP AAPEAPPAAP PPARPAAPAC GPTSSAGQEV
TGPERAPEAW LSRCRARTRS GGRGGEPQPR RAPPTRPRRP APPGRGRRRG EPAAEAERAP
AQPGDWGPRH MRWTPRGGLG CRARREGLES EHQPWGPWTA IMETESEQNS NSTNGSSSSG
GSSRPQIAQM SLYERQAVQA LQALQRQPNA AQYFHQFMLQ QQLSNAQLHS LAAVQQATIA
ASRQASSPNT STTQQQTTTT QASINLATTS AAQLISRSQS VSSPSATTLT QSVLLGNTTS
PPLNQSQAQM YLRPQLGNLL QVNRTLGRNV PLASQLILMP NGAVAAVQQE VPSAQSPGVH
ADADQVQNLA VRNQQASAQG PPMQGSTQKA IPPGASPVSS LSQASSQALA VAQASSGATS
QSLNLSQAGG GSGNSIPGSM GPGGGGQAHG GLGQLPSSGV GGGSCPRKGT GVVQPLPAAQ
TVTVSQGSQT EAESAAAKKA EADGSGQQNV GMNLTRTATP APSQTLISSA TYTQIQPHSL
IQQQQQIHLQ QKQVVIQQQI AIHHQQQFQH RQSQLLHTAT HLQLAQQQQQ QQQQQQQQQP
QATTLTAPQP PQVPPTQQVP PSQSQQQAQT LVVQPMLQSS PLSLPPDAAP KPPIPIQSKP
PVAPIKPPQL GTAKMSATQQ PPPHIPVQVV GTRQPGTAQA QALGLAQLAA AVPTSRGMPG
PVQSGQAHLA SSPPSSQAPG ALQECPPTLA PGMTLAPVQG TAHVVKGGAT TSSPVVAQVP
AAFYMQSVHL PGKPQTLPVK RKADSEEERD DVSTLGSMLP AKASPVAESP KVMDEKSSLG
EKAESVANMN ANTPGSELVA LTPAPSVPPP TLAMVSRQMG DSKPPQAIVK PQILTHIIEG
FVIQEGAEPF PVGCSQLLKE SEKPLQTGLP TGLTENQSGG PLGVDSPSAE LDKKANLLKC
EYCGKYAPAE QFRGSKRFCS MTCAKRYNVS CSHQFRLKRK KMKEFQEANY ARVRRRGPRR
SSSDIARAKI QGKCHRGQED SSRGSDNSSY DEALSPTSPG PLSVRAAHGE RDLGNPNTAP
PTPELHGINP VFLSSNPSRW SVEEVYEFIA SLQGCQEIAE EFRSQEIDGQ ALLLLKEEHL
MSAMNIKLGP ALKICAKINV LKET
//
