ID A0A2K5UFB8_MACFA Unreviewed; 492 AA.
AC A0A2K5UFB8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Threonine synthase-like 2 {ECO:0000256|ARBA:ARBA00021942};
GN Name=THNSL2 {ECO:0000313|Ensembl:ENSMFAP00000011069.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000011069.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000011069.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000011069.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR AlphaFoldDB; A0A2K5UFB8; -.
DR STRING; 9541.ENSMFAP00000011069; -.
DR Ensembl; ENSMFAT00000046224.2; ENSMFAP00000011069.2; ENSMFAG00000012127.2.
DR VEuPathDB; HostDB:ENSMFAG00000012127; -.
DR GeneTree; ENSGT00940000158503; -.
DR OrthoDB; 275600at2759; -.
DR Proteomes; UP000233100; Chromosome 13.
DR Bgee; ENSMFAG00000012127; Expressed in adult mammalian kidney and 13 other cell types or tissues.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR42690; THREONINE SYNTHASE FAMILY MEMBER; 1.
DR PANTHER; PTHR42690:SF1; THREONINE SYNTHASE-LIKE 2; 1.
DR Pfam; PF00291; PALP; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 3..81
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT DOMAIN 106..321
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT MOD_RES 113
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 492 AA; 55113 MW; A7BF4FE9BA741FD4 CRC64;
MWYVSTRGIA PRVDFEGALF SGYAPDGGLF MPEELPQLDR ETLCQWSTLS YPGLVKELCA
LFIGSELIPK DDLNDLIDRA FSRFRHREVV HLSRLRNGLN VLELWHGVTY AFKDLSLSCT
AQFLQYFLEK REKHVTVVVG TSGDTGSAAI ESVQGAKNVD IIVLLPKGHC TKIQELQMTT
VLKENVHVFG VEGNSDELDE PIKTVFADVA FVKKHNLMSL NSINWSRVLV QMAHHFFAYF
QCTPSLDTHP LPLVEVVVPT GAAGNLAAGY IAQKIGLPIR LVVAVNRNDI IHRTVQQGDF
SLSEAVKSTL ASAMDIQVPY NMERVFWLLF GCDSQVTRAL MEQFERTQSV NLPKELHSKE
KFYSLGMLSE VVTSESVSDE AITQTMGRCW DENQYLLCPH SAVAVNYHYQ QMDRQEPSTP
RCCLAPASAA KFPEAVLAAG LTPETPAEIV ALEHKETRCT PMRRGDNWTL ILQDTIEDLS
RRWRGHALNA SQ
//
