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Database: UniProt
Entry: A0A2K5UIW7_MACFA
LinkDB: A0A2K5UIW7_MACFA
Original site: A0A2K5UIW7_MACFA 
ID   A0A2K5UIW7_MACFA        Unreviewed;       359 AA.
AC   A0A2K5UIW7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=GDNF family receptor alpha-2 {ECO:0000256|ARBA:ARBA00016726};
GN   Name=GFRA2 {ECO:0000313|Ensembl:ENSMFAP00000012348.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000012348.1, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000012348.1, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000012348.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC       autophosphorylation and activation of the RET receptor. Also able to
CC       mediate GDNF signaling through the RET tyrosine kinase receptor.
CC       {ECO:0000256|ARBA:ARBA00025392}.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961}.
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DR   AlphaFoldDB; A0A2K5UIW7; -.
DR   STRING; 9541.ENSMFAP00000012348; -.
DR   Ensembl; ENSMFAT00000057606.2; ENSMFAP00000012348.1; ENSMFAG00000023628.2.
DR   VEuPathDB; HostDB:ENSMFAG00000023628; -.
DR   GeneTree; ENSGT00940000156168; -.
DR   OMA; DTGKPCN; -.
DR   Proteomes; UP000233100; Chromosome 8.
DR   Bgee; ENSMFAG00000023628; Expressed in frontal cortex and 2 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   InterPro; IPR003504; GDNF_rcpt_a2.
DR   PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   Pfam; PF02351; GDNF; 2.
DR   PRINTS; PR01318; GDNFRALPHA2.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 2.
DR   SUPFAM; SSF110035; GDNF receptor-like; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..359
FT                   /note="GDNF family receptor alpha-2"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014396601"
FT   DOMAIN          56..136
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          146..242
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   REGION          258..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        258..273
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   359 AA;  39621 MW;  97F1B12A070EE07C CRC64;
     MILANAFCLF FFLGEEFYEA SPYEPVTSRL SDIFRLASIF SGTGADPVVS AKSNHCLDAA
     KACNLNDNCK KLRSSYISIC NREISPTERC NRRKCHKALR QFFDRVPSEY TYRMLFCSCQ
     DQACAERRRQ TILPSCSYED KEKPNCLDLR GVCRTDHLCR SRLADFHANC RASYQTVTSC
     PADNYQACLG SYAGMIGFDM TPNYVDSSPT GIVVSPWCSC RGSGNMEEEC EKFLRDFTEN
     PCLRNAIQAF GNGTDVNVSP KGPSFQATQA PRVEKTPSLP DDLSDSTSLG TSVITTCTSV
     QEQGLKANNS KELSMCFTEL TTNIIPGSNK VIKPNSGPSR ARPSAALTVL SVLMLKLAL
//
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