ID A0A2K5UIW7_MACFA Unreviewed; 359 AA.
AC A0A2K5UIW7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=GDNF family receptor alpha-2 {ECO:0000256|ARBA:ARBA00016726};
GN Name=GFRA2 {ECO:0000313|Ensembl:ENSMFAP00000012348.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000012348.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000012348.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000012348.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for neurturin. Mediates the NRTN-induced
CC autophosphorylation and activation of the RET receptor. Also able to
CC mediate GDNF signaling through the RET tyrosine kinase receptor.
CC {ECO:0000256|ARBA:ARBA00025392}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR AlphaFoldDB; A0A2K5UIW7; -.
DR STRING; 9541.ENSMFAP00000012348; -.
DR Ensembl; ENSMFAT00000057606.2; ENSMFAP00000012348.1; ENSMFAG00000023628.2.
DR VEuPathDB; HostDB:ENSMFAG00000023628; -.
DR GeneTree; ENSGT00940000156168; -.
DR OMA; DTGKPCN; -.
DR Proteomes; UP000233100; Chromosome 8.
DR Bgee; ENSMFAG00000023628; Expressed in frontal cortex and 2 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003504; GDNF_rcpt_a2.
DR PANTHER; PTHR10269:SF4; GDNF FAMILY RECEPTOR ALPHA-2; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 2.
DR PRINTS; PR01318; GDNFRALPHA2.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 2.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..359
FT /note="GDNF family receptor alpha-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014396601"
FT DOMAIN 56..136
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 146..242
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 258..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 359 AA; 39621 MW; 97F1B12A070EE07C CRC64;
MILANAFCLF FFLGEEFYEA SPYEPVTSRL SDIFRLASIF SGTGADPVVS AKSNHCLDAA
KACNLNDNCK KLRSSYISIC NREISPTERC NRRKCHKALR QFFDRVPSEY TYRMLFCSCQ
DQACAERRRQ TILPSCSYED KEKPNCLDLR GVCRTDHLCR SRLADFHANC RASYQTVTSC
PADNYQACLG SYAGMIGFDM TPNYVDSSPT GIVVSPWCSC RGSGNMEEEC EKFLRDFTEN
PCLRNAIQAF GNGTDVNVSP KGPSFQATQA PRVEKTPSLP DDLSDSTSLG TSVITTCTSV
QEQGLKANNS KELSMCFTEL TTNIIPGSNK VIKPNSGPSR ARPSAALTVL SVLMLKLAL
//