ID A0A2K5UJH6_MACFA Unreviewed; 582 AA.
AC A0A2K5UJH6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Protein associated with LIN7 2, MAGUK p55 family member {ECO:0000313|Ensembl:ENSMFAP00000012533.1};
GN Name=PALS2 {ECO:0000313|Ensembl:ENSMFAP00000012533.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000012533.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000012533.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000012533.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR RefSeq; XP_015302765.1; XM_015447279.1.
DR AlphaFoldDB; A0A2K5UJH6; -.
DR STRING; 9541.ENSMFAP00000012533; -.
DR Ensembl; ENSMFAT00000058884.2; ENSMFAP00000012533.1; ENSMFAG00000024129.2.
DR VEuPathDB; HostDB:ENSMFAG00000024129; -.
DR GeneTree; ENSGT00940000158500; -.
DR OrthoDB; 2873706at2759; -.
DR Proteomes; UP000233100; Chromosome 3.
DR Bgee; ENSMFAG00000024129; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.287.650; L27 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF45; PROTEIN PALS2; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..50
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 91..149
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 172..251
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 257..326
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 380..567
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
SQ SEQUENCE 582 AA; 65936 MW; 6300230B03DA8202 CRC64;
MQQVLENLTE LPSSTGAEEI DLIFLKGIME NPIVKSLAKD EMTLSFGIMP LKFREITPAQ
LCFNRTCEKD PDSISIFNNG RAHERLEDSK LEAVSDNNLE LVNEILEDIT PLINVDENVA
ELVGILKEPH FQSLLEAHDI VASKCYDSPP SSPEMNNSSI NNQLLPVDAI RILGIHKRAG
EPLGVTFRVE NNDLVIARIL HGGMIDRQGL LHVGDIIKEV NGHEVGNNPK ELQELLKNIS
GSVTLKILPS YRDTITPQQV FVKCHFDYNP YNDNLIPCKE AGLKFSKGEI LQIVNREDPN
WWQASHVKEG GSAGLIPSQF LEEKRKAFVR RDWDNSGPFC GTISSKKKKK MMYLTTRNAE
FDRHEIQIYE EVAKMPPFQR KTLVLIGAQG VGRRSLKNRF IVLNPTRFGT TVPFTSRKPR
EDEKDGQAYK FVSRSEMEAD IKAGKYLEHG EYEGNLYGTK IDSILEVVQT GRTCILDVNP
QALKVLRTSE FMPYVVFIAA PELETLRAMH KAVVDAGITT KLLTDSDLKK TVDESARIQR
AYNHYFDLII INDNLDKAFE KLQTAIEKLR MEPQWVPISW VY
//
