ID A0A2K5ULH2_MACFA Unreviewed; 1274 AA.
AC A0A2K5ULH2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Plakophilin 4 {ECO:0000313|Ensembl:ENSMFAP00000013236.2};
GN Name=PKP4 {ECO:0000313|Ensembl:ENSMFAP00000013236.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000013236.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000013236.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000013236.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR AlphaFoldDB; A0A2K5ULH2; -.
DR Ensembl; ENSMFAT00000062541.2; ENSMFAP00000013236.2; ENSMFAG00000008546.2.
DR VEuPathDB; HostDB:ENSMFAG00000008546; -.
DR GeneTree; ENSGT00940000155773; -.
DR Proteomes; UP000233100; Chromosome 12.
DR Bgee; ENSMFAG00000008546; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0051233; C:spindle midzone; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR GO; GO:0007043; P:cell-cell junction assembly; IEA:Ensembl.
DR GO; GO:0032467; P:positive regulation of cytokinesis; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF8; PLAKOPHILIN-4; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT REPEAT 652..679
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 696..739
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 954..991
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 15..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1148..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 140055 MW; 45F091AF70022DB2 CRC64;
MGWRELARDG GVLTFPGARG WPGGRAGGQA GGGGGLWAVE GAPGLSPRRR RPRRRHHGQG
VEGKLATAAA GGGGRAAPGE GGGWGREGRA AARPQHFFNF AGAAAATLGA DVPDPWSDDG
RSLSWKELQF QRLTRELEVE RQIVASQLER CRLGAESPSI ASTSSTEKSF PWRATDVPNT
GVSKPKVSDA VHPNNYLIRT EPEQGTLYSP EQTSLHESEG SLGNSRSSTQ MNSYSDSGYQ
EAGSFHNSQN VSKADNRQQH SFIGSTNNHV VRNSRAEGQT LVQPSVANRA MRRVSSVPSR
AQSPSYVIST GVSPSRGSLR TSLGSGFGSP SVTDPRPLNP SAYSSTTLPA VRAASPYSQR
PASPTAIRRI GSVTSRQTSN PNGPTPQYQT TARVGSPLTL TDAQTRVASP SQGQVGSSSP
KRSGMTAVPQ HLGPSLQRTV HDMEQFGQQQ YDIYERMVPP RPDSLTGLRS SYASQHSQLG
QDLRSAVSPD LHITPIYEGR TYYSPVYRSP NHGTVELQGS QTALYRTGSV GIGNLQRTSS
QRSTLTYQRN NYALNTTATY AEPYRPIQYR VQECNYNRLQ HVVSADDGTT RSPSIDSIQK
DPREFAWRDP ELPEVIHMLQ HQFPSVQANA AAYLQHLCFG DNKVKMEVCR LGGIKHLVDL
LDHRVLEVQK NACGALRNLV FGKSTDENKI AMKNVGGIPA LLRLLRKSID AEVRELVTGV
LWNLSSCDAV KMTIIRDALS TLTNTVIVPH SGWNNSSFDD DHKIKFQTSL VLRNTTGCLR
NLSSAGEEAR KQMRSCEGLV DSLLYVIHTC VNTSDYDSKT VENCVCTLRN LSYRLELEVP
QARLLGLNEL DDLLGKESPS KDSEPSCWGK KKKKKKRTPQ EDQWDGVGPI PGLSKSPKGV
EMLWHPSVVK PYLTLLAESS NPATLEGSAG SLQNLSAGNW KFAAYIRAAV RKEKGLPILV
ELLRMDNDRV VSSVATALRN MALDVRNKEL IGKYAMRDLV NRLPGGNGPS VLSDETMAAI
CCALHEVTSK NMENAKALAD SGGIEKLVNI TKGRGDRSSL KVVKAAAQVL NTLWQYRDLR
SIYKKDGWNQ NHFITPVSTL ERDRFKSHPS LSTTNQQMSP IIQSVGSTSS SPALLGIRDP
RSEYDRTQPP MQYYNSQGDA THKGLYPGSS KPSPIYISSY SSPAREQNRR LQHQQLYYSQ
DDSNRKNFDA YRLYLQSPHS YEDPYFDDRV HFPASTDYST QYGLKSTTNY VDFYSTKRPS
YRAEQYPGSP DSWV
//
