ID A0A2K5UMS0_MACFA Unreviewed; 382 AA.
AC A0A2K5UMS0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=TNF receptor superfamily member 10a {ECO:0000313|Ensembl:ENSMFAP00000013690.2};
GN Name=TNFRSF10A {ECO:0000313|Ensembl:ENSMFAP00000013690.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000013690.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000013690.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000013690.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
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DR AlphaFoldDB; A0A2K5UMS0; -.
DR STRING; 9541.ENSMFAP00000013690; -.
DR Ensembl; ENSMFAT00000063895.2; ENSMFAP00000013690.2; ENSMFAG00000029610.2.
DR VEuPathDB; HostDB:ENSMFAG00000029610; -.
DR GeneTree; ENSGT00940000162957; -.
DR OrthoDB; 4604019at2759; -.
DR Proteomes; UP000233100; Chromosome 8.
DR Bgee; ENSMFAG00000029610; Expressed in bone marrow and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045569; F:TRAIL binding; IEA:InterPro.
DR CDD; cd10580; TNFRSF10; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020465; TNFR_10.
DR InterPro; IPR034024; TNFRSF10_N.
DR PANTHER; PTHR46330; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; 1.
DR PANTHER; PTHR46330:SF10; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10D; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01956; TNFACTORR10.
DR SMART; SM00208; TNFR; 2.
DR SUPFAM; SSF57586; TNF receptor-like; 3.
DR PROSITE; PS00652; TNFR_NGFR_1; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00206}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 206..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 97..138
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 97..138
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 139..179
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 139..179
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 282..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 117..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 120..138
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 161..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 382 AA; 40675 MW; 333CE134E1D3BF1B CRC64;
MGLCGQSAPT ASSARAGRSP GARTASGTTP WLPDPKTLKF VFVIVAVLLP VQVDSATISR
KDEVPLPPVA SKQQRRSLDA ECPAGFHRSE HTGACNPCTE GVDYTIASNN LPSCLLCTVC
KSGQTNTSSC TTTRDTVCQC EKGSFQDANS PEMCRKCSTG CPRGMIKVSD CTPWSDINCS
ASAASSTGKT PAAEDTVPTS LGTPDLYGLI AGVVTVFIIL FAAAFVCILR RKKLISSLKG
ICSGGGGDPE RVHRVFFRRS RPSRVPGTED NARNESLSTR FLQPTQVSEQ EIKGQESAEP
TGVTVQSPEE AQRLLEQAVA EGRQRKTLPV PVNDADPTEI NTLLDASATL EEGHAKETIQ
DHMVDSEKLF YEDDAGFATS SL
//
