ID A0A2K5UQV2_MACFA Unreviewed; 763 AA.
AC A0A2K5UQV2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Forkhead box M1 {ECO:0000313|Ensembl:ENSMFAP00000014798.2};
GN Name=FOXM1 {ECO:0000313|Ensembl:ENSMFAP00000014798.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000014798.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000014798.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000014798.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR AlphaFoldDB; A0A2K5UQV2; -.
DR STRING; 9541.ENSMFAP00000014798; -.
DR Ensembl; ENSMFAT00000065305.2; ENSMFAP00000014798.2; ENSMFAG00000030561.2.
DR VEuPathDB; HostDB:ENSMFAG00000030561; -.
DR GeneTree; ENSGT00940000158804; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000233100; Chromosome 11.
DR Bgee; ENSMFAG00000030561; Expressed in bone marrow and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IEA:Ensembl.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IEA:Ensembl.
DR GO; GO:0032873; P:negative regulation of stress-activated MAPK cascade; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IEA:Ensembl.
DR GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; IEA:Ensembl.
DR CDD; cd20029; FH_FOXM; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR047516; FH_FOXM1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR042839; FOXM1.
DR InterPro; IPR018122; TF_fork_head_CS_1.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46878; FORKHEAD BOX PROTEIN M1; 1.
DR PANTHER; PTHR46878:SF1; FORKHEAD BOX PROTEIN M1; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00657; FORK_HEAD_1; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 236..329
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 236..329
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 482..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 84238 MW; 5474D03ADDE69D74 CRC64;
MKTSPRRPLI LKRRRLPLPV QNAPSETSEE EPKRSPARQE PNQAEASKEV AESNTCKFPA
GIKIINHPTM SNTQVVAIPN NADIHSIITA LTAKGKESGS SGPNKFILIS CGGAPTQPPG
LQPQTQTSYD AKRTEVTLET LGPQPAARDG NLPRPPGALC EQKRETCADG EAAGCTINKS
LSNIQWLRKT SSDGLGSCSI KQEMEEKENC HLEQRQVKVE EPSRPSMSWQ NSVSERPPYS
YMAMIQFAIN STERKRMTLK DIYTWIEDHF PYFKHIAKPG WKNSIRHNLS LHDMFVRETS
ANGKVSFWTI HPSANRYLTL DQVFKPLDPG SPQLPEHLES QQKRPNPELR RNMTIKTELP
LSARRKMKPL LPRVSSYLVP IQFPVNQSLV LQPSVKVPLP LAASLMSSEL ARHSKRVRIA
PKVLLAEEGT APLPSAGPGK EEKLLCGEGL CPLLPVQSIK EEQIQPGEEM PHLARPIKVE
SPPLEEWPSP APSFKEESSH SWEDSPQSPT PRPKKSYGGL RSPTRCVSEM LVIPHRERRE
RSRSRRKQHL LPPCVAEPEL LFSEGPSTSR WAAELPFPAD SSQPAPQLSY PQEEGGPFKT
PIKETLPISS TPSKSVLPRT PESWRLTPPA KVGGLDFSPV QTPQGASGPL PDPLELMDLS
TTPLKSVPPF ESPQRLLSSE PLDLASVPFG NSSPSDIEVP KPGSPEPQVS GLAANRSLTE
GLVLDTMNDS LSKILLDISF PGLEEDPLGP DNINWSQFIP ELQ
//
