ID A0A2K5URQ5_MACFA Unreviewed; 1195 AA.
AC A0A2K5URQ5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Potassium voltage-gated channel subfamily H member 7 {ECO:0000313|Ensembl:ENSMFAP00000015055.1};
GN Name=KCNH7 {ECO:0000313|Ensembl:ENSMFAP00000015055.1};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000015055.1, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000015055.1, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000015055.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_005573381.1; XM_005573324.2.
DR AlphaFoldDB; A0A2K5URQ5; -.
DR STRING; 9541.ENSMFAP00000015055; -.
DR Ensembl; ENSMFAT00000065574.2; ENSMFAP00000015055.1; ENSMFAG00000030695.2.
DR GeneID; 102137999; -.
DR KEGG; mcf:102137999; -.
DR CTD; 90134; -.
DR VEuPathDB; HostDB:ENSMFAG00000030695; -.
DR GeneTree; ENSGT00940000155518; -.
DR OMA; MRTSHPV; -.
DR OrthoDB; 66005at2759; -.
DR Proteomes; UP000233100; Chromosome 12.
DR Bgee; ENSMFAG00000030695; Expressed in temporal lobe and 3 other cell types or tissues.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 1.10.1200.260; -; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR003967; K_chnl_volt-dep_ERG.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR10217:SF466; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY H MEMBER 7; 1.
DR PANTHER; PTHR10217; VOLTAGE AND LIGAND GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR PRINTS; PR01470; ERGCHANNEL.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 411..432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..665
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 744..844
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 193..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1027..1054
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 884..914
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 134884 MW; C81E2C65E79971C4 CRC64;
MPVRRGHVAP QNTFLGTIIR KFEGQNKKFI IANARVQNCA IIYCNDGFCE MTGFSRPDVM
QKPCTCDFLH GPETKRHDIA QIAQALLGSE ERKVEVTYYH KNGSTFICNT HIIPVKNQEG
VAMMFIINFE YVTDENAATP ERVNPILPVK TVNRKFFGFK FPGLRVLTYR KQSLPQEDPD
VVVIDSSKHS DDSVAMKHFK SPTKESCSPS EADDTKALIQ PSKCSPLVNI SGPLDHSSPK
RQWDRLYPDM LQSSSQLSHS RSRESLCSIR RASSVHDIEG FSVHPKNIFR DRHASEDNGR
NVKGPFNHIK SSLLGSTSDS NLNKYSTINK IPQLTLNFSE AKTEKKNSSP PSSDKTIIAP
KVKDRTHNVT EKVTQVLSLG ADVLPEYKLQ TPRINKFTIL HYSPFKAVWD WLILLLVIYT
AIFTPYSAAF LLNDREEQKR RECGYSCSPL NVVDLIVDIM FIIDILINFR TTYVNQNEEV
VSDPAKIAIH YFKGWFLIDM VAAIPFDLLI FGSGSDETTT LIGLLKTARL LRLVRVARKL
DRYSEYGAAV LMLLMCIFAL IAHWLACIWY AIGNVERPYL TDKIGWLDSL GQQIGKRYND
SDSSSGPSIK DKYVTALYFT FSSLTSVGFG NVSPNTNSEK IFSICVMLIG SLMYASIFGN
VSAIIQRLYS GTARYHMQML RVKEFIRFHQ IPNPLRQRLE EYFQHAWTYT NGIDMNMVLK
GFPECLQADI CLHLNQTLLQ NCKAFRGASK GCLRALAMKF KTTHAPPGDT LVHCGDVLTA
LYFLSRGSIE ILKDDIVVAI LGKNDIFGEM VHLYAKPGKS NADVRALTYC DLHKIQREDL
LEVLDMYPEF SDHFLTNLEL TFNLRHESAK ADLLRSQSMN DSEGDNCKLR RRKLSFESEG
EKENSTNDPE DSADTIRHYQ SSRRHFEEKK SRSSSFISSI DDEQKPLFSG IVDSSPGIGK
ASGLDFEETV PTSGRMHIDK RSHSCKDITD MRSWERENAH PQPEDSSPSA LQRAAWGISE
TESDLTYGEV EQRLDLLQEQ LNRLESQMTT DIQTILQLLQ KQTTVVPPAY SMVTAGAEYQ
RPIIRLMRTS QPAASIKTDR SFSPSSQCPE FLDLEKSKLK SKESLSSGVH LNTASEDNLT
SLLKQDSDLS LELHLRQRKT YLHPIRHPSL PDSSLSTVGI LGLHRHVSDP GLPGK
//
