ID A0A2K5USI0_MACFA Unreviewed; 1829 AA.
AC A0A2K5USI0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=DENN domain containing 4A {ECO:0000313|Ensembl:ENSMFAP00000015398.2};
GN Name=DENND4A {ECO:0000313|Ensembl:ENSMFAP00000015398.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000015398.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000015398.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000015398.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR Ensembl; ENSMFAT00000065925.2; ENSMFAP00000015398.2; ENSMFAG00000030601.2.
DR VEuPathDB; HostDB:ENSMFAG00000030601; -.
DR GeneTree; ENSGT00940000155836; -.
DR Proteomes; UP000233100; Chromosome 7.
DR Bgee; ENSMFAG00000030601; Expressed in bone marrow and 13 other cell types or tissues.
DR GO; GO:0000813; C:ESCRT I complex; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.100.10.50; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR023341; MABP.
DR InterPro; IPR018798; MVB12A/B.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR12296:SF16; C-MYC PROMOTER-BINDING PROTEIN; 1.
DR PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF10240; DUF2464; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS51498; MABP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 42..200
FT /note="MABP"
FT /evidence="ECO:0000259|PROSITE:PS51498"
FT DOMAIN 192..641
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 719..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1070
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..895
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1060
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1222..1236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1245..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1829 AA; 205195 MW; 2A58DDB156982D1E CRC64;
MIEDKGPRVA DYFVVAGLTD VSKPLEEEIH FNDACHKVAK PKEPITDVSV IIKSLGEEVP
RDYICIDSTP TGLSADLNNG SLVGPQIYLC YRRGRDKPPL TDLGVLYDWK ERLKQGCEII
QSTPYGRPAN ISGSTSSQRI YITYRRASEN MTQNTLAVTD ICIIIPSKGE SPPHTFCKVD
KNLNNSMWGS AVYLCYKKSV AKTNTISYKA GLICRYPQED YESFSLPESV PLFCLPMGAT
IECWPSNSKY PLPVFSTFVL TGASAEKVYG AAIQFYEPYS EENLTEKQRL LLGLTSADGK
SDSSKTIHTN KCICLLSHWP FFDAFRKFLT FLYRYSISGP HVLPIEKHIS HFMHKVPFPS
PQRPRILVQL SPHDNLILSQ PVSSPLPLSG GKFSTLLQNL GPENAVTLLV FAVTEHKILI
HSLRPSVLTS VTEALVSMIF PFHWPCPYVP LCPLALADVL SAPCPFIVGI DSRYFDLYDP
PPDVSCVDVD TNTISQIGDK KNVAWKILPK KPCKNLMNTL NNLHQQLAKL QQRPRDDGLM
DLAMNDYDFN SGKRLHMIDL EIQEAFLFFM ASILKGYRSY LRPITQAPSE TATDAASLFA
LQAFLRSRDR SHQKFYNMMT KTQMFIRFIE ECSFVSDKDA SLAFFDDCVD KVDMDKSGEV
RLIELDESFK SEHTVFVTPP EIPHLPNGEE PPLQYSYNGF PVLRNNLFER PEGFLQAKKN
KLPSKSSSPN SPSPMFRRTK QEIKSAHKIA KRYSSIPQMW SRCLLRHCYG LWFICLPAYV
KVCHSKVRAL KTAYDVLKKM QSKKMDPPDE AVLESTWPSR SRSGYFLWTK VRNVILGVTQ
FKRALKKHAH LSQTTLSGGQ SDLGYNSLSK DEVRRGDTST EDIQEEKDKK GSDCSSLSES
ESAKGSADCL PKLSYQNSSS IVRLTGTSNN SADKISGESM ESTPELLLIS SLEDTNGTRN
IQSRCFRKRH KSDNETNLQQ QVVWGNRNRN LSGGVLMGFM LNRINQEATP GDIVEKLGAD
AKILSNVISK STRPNTLDIG KPPLRSKRDS LEKESSDDDT PFDGSNYLGD KVESPVIFDL
EDLDSETDGS KAGCVATQNP KSIQRMNSSF SVKPFEKTDV ATGFDPLSLL VAETEQQQKE
EEEEDEDDSK SISTPSARRD LAEEIVMYMN NMSSPLTSRT PSIDLQRACD DKLNKKSPPL
VKACRRSSLP PNSPRPVRLT KSKSYTKSEE KPRERLWSSP AFSPTCPFRE ESQDTLTHSS
PSFNLDTLLV PKLDVLRNSM FTAGKGVAEK ASKWYSRFTM YTTSSKDQSS DRTSLSSVGA
QDSESTSLTD EDVCHELDGA TSSQETSATS GTKRIDLSRI SLESSASLEA SLSKFALPGK
SEVTSSFTAS NTNIFQNYAM EVLISSCSRC RTCDCLVHDE EIMAGWTADD SNLNTTCPFC
GNIFLPFLNI EIRDLRRPGR YFLKSSPSTE NIHFPSSISS QMRQSCISTS ASGLDTSAVS
VQGNFDLNSK SKLQENFCAR SIQIPANRSK TAMSKCPIFP MARSISTSGP LDKEDTGRQK
LISTGSLPAT LQGATDSLGL EWQLPSPDPV TVPYLSPLVV WKELESLLEN EGDHAITVAD
FVDHHPIVFW NLVWYFRRLD LPSNLPGLIL SSEHCNKYSK IPRHCMSEDS KYVLIQMLWD
NMKLHQDPGQ PLYILWNAHS QNRTLLFETQ KYPMVHLLQK SDNSFNQELL KSMVKSIKMN
DVYGPMSQIL ETLNKCPHFK RQRSLYREIL FLSLVALGRE NIDIDAFDKE YKMAYDRLTP
SQVKSTHNCD RPPSTGVMEC RKTFGEPYL
//
