ID   A0A2K5USM3_MACFA        Unreviewed;       776 AA.
AC   A0A2K5USM3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=FCH and mu domain containing endocytic adaptor 2 {ECO:0000313|Ensembl:ENSMFAP00000015441.2};
GN   Name=FCHO2 {ECO:0000313|Ensembl:ENSMFAP00000015441.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000015441.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000015441.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000015441.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane, clathrin-coated pit
CC       {ECO:0000256|ARBA:ARBA00004283}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004283}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004283}.
CC   -!- SIMILARITY: Belongs to the FCHO family.
CC       {ECO:0000256|ARBA:ARBA00011064}.
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DR   AlphaFoldDB; A0A2K5USM3; -.
DR   Ensembl; ENSMFAT00000065968.2; ENSMFAP00000015441.2; ENSMFAG00000030926.2.
DR   VEuPathDB; HostDB:ENSMFAG00000030926; -.
DR   GeneTree; ENSGT00940000157105; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   Bgee; ENSMFAG00000030926; Expressed in lung and 13 other cell types or tissues.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   CDD; cd09267; FCHo2_MHD; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR028565; MHD.
DR   InterPro; IPR018808; Muniscin_C.
DR   PANTHER; PTHR23065:SF8; F-BAR DOMAIN ONLY PROTEIN 2; 1.
DR   PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF10291; muHD; 1.
DR   SMART; SM00055; FCH; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          3..254
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          508..775
FT                   /note="MHD"
FT                   /evidence="ECO:0000259|PROSITE:PS51072"
FT   REGION          268..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..421
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..503
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   776 AA;  85117 MW;  12C713A7F477E99B CRC64;
     MVMAYFVENF WGEKNSGFDV LYHNMKHGQI STKELADFVR ERATIEEAYS RSMTKLAKSA
     SNYSQLGTFA PVWDVFKTST EKLANCHLDL VRKLQELIKE VQKYGEEQVK SHKKTKEEVA
     GTLEAVQTIQ SITQALQKSK ENYNAKCVEQ ERLKKEGATQ REIEKAAVKS KKATDTYKLY
     VEKYALAKAD FEQKMTETAQ VHEEFINNMA NTTVESLIQK FAESKGTGKE RPGLIEFEEC
     DTASAVEGIK PRKRKTFALP GIIKKEKDAE SVECPDADSL NIPDVDEEGY SIKPETNQND
     TKENHFYSSS DSDSEDEEPK KYRIEIKPMH PNNSHHTMAS LDELKVSIGN ITLSPAISRH
     SPVQMNRNLS NEELTKSKPS APPNEKGTSD LLAWDPLFGP SLDSSSSSLT SSSSARPTTP
     LSVGTIVPPP RPASRPKLTS GKLSGINEIP RPFSPPVTSN TSPPPAAPLA RAESSSSISS
     SASLSAANTP TVGVSRGPSP VSLGNQDTLP VAVALTESVN AYFKGADPTK CIVKITGDMT
     MSFPSGIIKV FTSNPTPAVL CFRVKNISRL EQILPNAQLV FSDPSQCDSN TKDFWMNMQA
     VTVYLKKLSE QNPAASYYNI DVLKYQVSSN GIQSTPLNLA TYWKCSASTT DLRVDYKYNP
     EAMVAPSVLS NIQVVVPVDG GVTNMQSLPP AIWNAEQMKA FWKLSSISEK SENGGSGSLR
     AKFDLSEGPS KPMTLAVQFL SEGSTLSGVD FELIGTGYRL SLIKKRFATG RYLADC
//