ID A0A2K5USZ4_MACFA Unreviewed; 460 AA.
AC A0A2K5USZ4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Differentially expressed in FDCP 8 homolog {ECO:0000313|Ensembl:ENSMFAP00000015564.2};
GN Name=DEF8 {ECO:0000313|Ensembl:ENSMFAP00000015564.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000015564.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000015564.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000015564.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
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DR AlphaFoldDB; A0A2K5USZ4; -.
DR STRING; 9541.ENSMFAP00000015564; -.
DR Ensembl; ENSMFAT00000066091.2; ENSMFAP00000015564.2; ENSMFAG00000031002.2.
DR VEuPathDB; HostDB:ENSMFAG00000031002; -.
DR GeneTree; ENSGT00940000159182; -.
DR Proteomes; UP000233100; Chromosome 20.
DR Bgee; ENSMFAG00000031002; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR PANTHER; PTHR12326:SF3; DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG; 1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM01175; DUF4206; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 147..198
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 23..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 53252 MW; 96751EAB205CC773 CRC64;
SRAGALWDAM EYDEKLARFR QAHLNPFNKQ SGPRQHEQGP GEEAPDITPE EALPELPPGE
PEFRCPERVM DLGLSEDHFS RPVGLFLASD VQQLRQAIEE CKQVILELPE QSEKQKDAVV
RLIHLRLKLQ ELKDPNEDEP NIRVLLEHRF YKEKSKSVKQ TCDKCNTIIW GLIQTWYTCT
GCYYRCHSKC LNLISKPCVS SKVSHQAEYE LNICPETGLD SQDYRCAECR APISLRGVPS
EARQCDYTGQ YYCSHCHWND LAVIPARVVH NWDFEPRKVS RCSMRYLALM VSRPVLRLRE
INPLLFNYVE ELVEIRKLRQ DILLMKPYFI TCREAMEARL LLQLQDRQHF VENDEMYSVQ
DLLDVHAGRL GCSLTEIHTL FAKHIKLDCE RCQAKGFVCE LCREGDVLFP FDSHTSVCTD
CSAVFHRDCY YDNSTTCPKC ARLSLRKQSL FQEPGPDVEA
//
