ID A0A2K5UTI4_MACFA Unreviewed; 681 AA.
AC A0A2K5UTI4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=RAD17 checkpoint clamp loader component {ECO:0000313|Ensembl:ENSMFAP00000015764.2};
GN Name=RAD17 {ECO:0000313|Ensembl:ENSMFAP00000015764.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000015764.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000015764.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000015764.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the rad17/RAD24 family.
CC {ECO:0000256|ARBA:ARBA00006168}.
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DR AlphaFoldDB; A0A2K5UTI4; -.
DR STRING; 9541.ENSMFAP00000015764; -.
DR Ensembl; ENSMFAT00000066291.2; ENSMFAP00000015764.2; ENSMFAG00000031075.2.
DR VEuPathDB; HostDB:ENSMFAG00000031075; -.
DR GeneTree; ENSGT00440000039046; -.
DR OrthoDB; 2881303at2759; -.
DR Proteomes; UP000233100; Chromosome 6.
DR Bgee; ENSMFAG00000031075; Expressed in pituitary gland and 13 other cell types or tissues.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0031389; C:Rad17 RFC-like complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IEA:Ensembl.
DR GO; GO:0008156; P:negative regulation of DNA replication; IEA:Ensembl.
DR GO; GO:0042325; P:regulation of phosphorylation; IEA:Ensembl.
DR CDD; cd18139; HLD_clamp_RarA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004582; Checkpoint_prot_Rad17_Rad24.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018324; Rad17/Rad24_fun/met.
DR NCBIfam; TIGR00602; rad24; 1.
DR PANTHER; PTHR12172; CELL CYCLE CHECKPOINT PROTEIN RAD17; 1.
DR PANTHER; PTHR12172:SF0; CELL CYCLE CHECKPOINT PROTEIN RAD17; 1.
DR Pfam; PF03215; Rad17; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT REGION 42..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..681
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 618..664
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 681 AA; 77122 MW; 1FC46D716D073D9E CRC64;
MSKTFLRPKV SSTKVTDWVD PSFDDFLECR DISTITATSL GVNNSSHRRK NGPSTLESSK
FPARKRGNLS SLEQIYGLEN SKESLSENEP WVDKYKPETQ HELAVHKKKI EEVETWLKAQ
VLERQPKQGG SILLITGPPG CGKTTTIKVL SKEHGIQVQE WINPVLPDFQ KDDFREIFNT
ESSFHMFPYQ SQIAVFKEFL LRATKYNKLQ MLGDDLRTDK KIILVEDLPN QFYRDSHTLH
EVLRKYVRIG RCPLIFVISD SLSGDNNQRL LFPKEIQEEC SISNISFNPV APTIMMKFLN
RIVTIEANKN GGKITVPDKT SLELLCQGCS GDIRSAINSL QFSSSKGENN LWPRKKGMSL
KSDAVLSKSK RRKKPDRVFE NQEVQAIGGK DVSLFLFRAL GKILYCKRAS LTELDSPRLP
SHLSEYERDT LLVEPEEIVE MSHMPGDLLN LYLHQNYIDF FMDIDDIVRA SEFLSFADIL
SGDWNTCSLL REYSTSIATR GVIHSNKARG YAHCQGGGSS FRPLHKPQWF LIYKKYRENC
LAAKALFPDF CLPALCLQTQ LLPYLALLTI PMRNQAQISF IQDIGRLPLK RHFGRLKMEA
LTDREHGMID PDSGDEAQLN GGHSTEESLG EPTQATAPET WSLPLSQNSA SELPASQPQP
FSAQGDMEEN IIIEDYESDG T
//