ID A0A2K5UUR0_MACFA Unreviewed; 864 AA.
AC A0A2K5UUR0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Testis anion transporter 1 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 8 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A8 {ECO:0000313|Ensembl:ENSMFAP00000016198.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000016198.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000016198.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000016198.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|ARBA:ARBA00008692, ECO:0000256|RuleBase:RU362052}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A2K5UUR0; -.
DR Ensembl; ENSMFAT00000066728.2; ENSMFAP00000016198.2; ENSMFAG00000031229.2.
DR VEuPathDB; HostDB:ENSMFAG00000031229; -.
DR GeneTree; ENSGT01100000263544; -.
DR Proteomes; UP000233100; Chromosome 4.
DR Bgee; ENSMFAG00000031229; Expressed in multicellular organism and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0098661; P:inorganic anion transmembrane transport; IEA:UniProtKB-UniRule.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR PANTHER; PTHR11814:SF11; TESTIS ANION TRANSPORTER 1; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|RuleBase:RU362052};
KW Differentiation {ECO:0000256|RuleBase:RU362052};
KW Meiosis {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Spermatogenesis {ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 91..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 147..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 195..217
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 252..271
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 344..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 385..411
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 437..689
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
FT REGION 747..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 751..766
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..790
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 823..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97162 MW; F2379BC598BC889C CRC64;
MAQLERSAIS GFSSKSRQSS FPYDVKREVY NEETFQQEHK RKASSSGNMN INITTFTHHV
QCRCSWHRFL RCMLTIFPFL EWMCMYRLKD WLLGDLLAGI SVGLVQVPQG LTLSLLARQL
IPPLNIAYAA FCSSVIYVIF GSCHQMSIGS FFLVSALLIN VLKISPFNNG HLVMGSFLKD
EFSAPSYLMG YNKSLSVVAT TTFLTGIIQI IGFTVIANKI TMATETSQTL IDMIPYSFLF
PVTPDFSVLP KIILQAISLS LVSSFLLIFL GKKIASLHNY SVNSNQDLIA IGLCNVVSSF
FRSCVFTGAV ARTIIQDKSG GRQQFASLVG AGVMLLLMVK MGHFFYALPN AVLAGIILSN
VVPYLETISN LPSLWRQDQY DCALWMMTFS SSIFLGLDIG LIISVVSAFF ITSVPHRAKI
LLLGQIPNTN IYRSVNDYRE IITIPGVKIF QCCSSITFVN VYYLKHKLLK EVGMVRVPLK
EEEIFSLFNS SDTSLQGEKI CRCFCNCDDL EPLPRILYTE RFENKLDPDA SSVNLIHCSH
FESVNTSQTA SEDQVPYTVS SMSQKNQGQQ YEEVEKVWLP NNSSRNSSPG LPDVAESQGR
RSLIPYSDGS LLPSVHTIIL DFSMVHYVDS QGLVVLRQIC NAFRNANILI LIAGCHSSIV
RAFERNDFFD AGITKTQLFL SVHDAVLFAL SRKVIDSSEL SIDESETVIR ETYSETEKND
NSIYKMSSSF LGSQRNVSPG FTKIQQPVEE ESELDLELES EQEAGLGLDL DLDRELEPEM
EPKAETETET ETEMEPQPET EPEMEPDPKF RSRAHTFPQQ HYWPTYHPRT ASTQSQTQPR
TWSVERRRHP MDSYSPEGNS NEDV
//