ID A0A2K5UWS5_MACFA Unreviewed; 1078 AA.
AC A0A2K5UWS5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=DENN domain containing 1A {ECO:0000313|Ensembl:ENSMFAP00000016908.2};
GN Name=DENND1A {ECO:0000313|Ensembl:ENSMFAP00000016908.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000016908.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000016908.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000016908.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5UWS5; -.
DR STRING; 9541.ENSMFAP00000016908; -.
DR Ensembl; ENSMFAT00000067446.2; ENSMFAP00000016908.2; ENSMFAG00000031585.2.
DR VEuPathDB; HostDB:ENSMFAG00000031585; -.
DR GeneTree; ENSGT00940000156261; -.
DR Proteomes; UP000233100; Chromosome 15.
DR Bgee; ENSMFAG00000031585; Expressed in temporal lobe and 13 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 6.10.140.1000; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR040032; DENND1A/B/C.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13196; DENN DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR13196:SF22; DENN DOMAIN-CONTAINING PROTEIN 1A; 1.
DR Pfam; PF03455; dDENN; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT DOMAIN 80..445
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 545..559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..616
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1028
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 118152 MW; A5CCF6450445C0F1 CRC64;
MLESPKRLIK GDRGPQGEGR AESPHGSTQP PSGFPVGMWG LLQALRGKEE ERPSDGEVDG
VMQKRFCTEL TGKQNPETTF EVYVEVAYPR TGGTLSDPEV QRQFPEDYSD QEVLQTLTKF
CFPFYMDSLT VSQVGQNFTF VLTDIDSKQR FGFCRLSSGA KSCFCILSYL PWFEVFYKLL
NILADYTTKR QENQWNELLE TLHKLPIPDP GVSVHLSVHS YFTVPDTREL PSIPENRNLT
EYFVAVDVNN MLHLYASMLY ERRILIICSK LSTLTACIHG SAAMLYPMYW QHVYIPVLPP
HLLDYCCAPM PYLIGIHLSL MEKVRNMALD DVVILNVDTN TLETPFDDLQ SLPNDVISSL
KNRLKKVSTT TGDGVARAFL KAQAAFFGSY RNALKIEPEE PITFCEEAFV SHYRSGAMRQ
FLQNATQLQL FKQFIDGRLD LLNSGEGFSD VFEEEINMGE YAGSDKLYHQ WLSTVRKGSG
AILNTVKTKA NPAMKTVYKF AKDHAKMGIK EVKNRLKQKD IAENGCAPTP EEQLPKTAPS
PLVEAKDPKL REDRRPITVH FGQVRPPRPH VVKRPKSNIT VEGRRTSVPS PEQPQPYRTL
KESDSAEGDE AESPEQQVRK PTGPVPAPTD RAASIDLLED VFNNLDMEAA LQPLGQAKSL
EDLRAPKDLR EQPGTFDYQR LDLGGSERSR GVTVALKLTH PYNKLWSLGQ DDMAIPSKPP
AASPDKPSAL LGNSLALPRR PQNRDSILNP SDKEEVPTPT LGSITIPRPQ GRKTPELGIV
PPPPIPRPAK LQAAGTALGD FSERLQVDRD RRAALSPGLL PGGVPQGPTE LLQPLSPSPG
TAGTSSDALL ALLDPLSTAW SGSTLPPRHA APNVATPFTP QFSFPPAGTP APFPQPPLNP
FVPSMPAAPP TLSLVSTPAG PFGVPPASLG PAFASGLLLS SAGFCAPHRS QPNLSALSMP
NLFGQMPMGT HTSPLQPLGP PAVAPSRIRT LPLARSSARA AEAKQGLALR PGDPPLLPPR
PPQGLEPTLQ PSAPQQARDP FEDLLQKTKQ DVSPSPVLAP APAPDSVEQL RKQWETFE
//
