ID A0A2K5V039_MACFA Unreviewed; 3143 AA.
AC A0A2K5V039;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Eyes shut homolog {ECO:0000313|Ensembl:ENSMFAP00000018082.2};
GN Name=EYS {ECO:0000313|Ensembl:ENSMFAP00000018082.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000018082.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000018082.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000018082.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMFAT00000068625.2; ENSMFAP00000018082.2; ENSMFAG00000032080.2.
DR VEuPathDB; HostDB:ENSMFAG00000032080; -.
DR GeneTree; ENSGT00940000163729; -.
DR Proteomes; UP000233100; Chromosome 4.
DR Bgee; ENSMFAG00000032080; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 14.
DR CDD; cd00110; LamG; 5.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 25.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED; 1.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02210; Laminin_G_2; 5.
DR SMART; SM00181; EGF; 27.
DR SMART; SM00179; EGF_CA; 20.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 22.
DR PROSITE; PS01186; EGF_2; 14.
DR PROSITE; PS50026; EGF_3; 23.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..3143
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030051228"
FT DOMAIN 170..212
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 213..254
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 256..292
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 643..679
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 681..720
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 733..769
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 771..807
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 809..847
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 849..888
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 890..926
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 928..964
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 966..1002
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1004..1040
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1079..1115
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1117..1159
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1161..1197
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1883..2063
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2099..2140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2145..2339
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2335..2368
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2371..2408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2419..2609
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2610..2646
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2648..2689
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2696..2874
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2875..2911
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2912..2949
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2954..3143
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 183..200
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 202..211
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 244..253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 260..270
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 282..291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 669..678
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 759..768
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 797..806
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 818..835
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 837..846
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 878..887
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 916..925
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 954..963
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 992..1001
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1030..1039
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1105..1114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1149..1158
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1187..1196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2130..2139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2398..2407
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2636..2645
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2679..2688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2847..2874
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 2901..2910
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2939..2948
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3143 AA; 348676 MW; 8F136876C8F2A990 CRC64;
MTDKSIIILS LMVFHSSFIN GKTCRRELVE EWHPQPSSHV VNWTLTENIC LDYYRDCWFL
GVNTKIDTSG NQVVPQICPL QIQLGDILVI SSEPSLQFPE INLMNVSETS FIGCVQNTTT
EDQLLFGCRL KGMHTVNSKW LSVGTHYFIT VMASGPSPCP LGLRLNVTVK QQFCQESLSS
EFCSGHGKCL SEAWSKTYSC HCQPPFSGKY CQELDACSFK PCKNDGSCIN KRGNWDEQGY
ECVCHPPFTG KNCSEIIGQC QPHVCFHGNC SNITSNSFIC ECDEQFSGPF CEVSTKPCVS
LLCWKRGICP NSSSAYTYEC PKGPSSQNGE TDVSECSLIL CENGTDGIKI SNDVMCICSP
IFTDLLCKSF QTSCESFPLK NNATFKKCEK DYHCSCMSGF TGKNCEKVID HCKLLSINCL
NEEWCFNIIG RFKYVCIPGC TKNPFWFLKN VHLIHLHPCY YGITFHGICQ DKGPAHFEYV
WQLGFTGSEG EKCQGVIDAY FFLTANCTED AIYVNNPEDN NSSCSFPCEG TKEICANGCS
CLSEEDNQEY RYLCFLRWTS NMYLENITDD QENKSQHEAI CEDEINRPRC SCSLSYIGRL
CVVNVDYCLG NQSISVHGLC LALSHNCNCS DLQKYEGNIC EIDIEDCKSV SCKNGTTSIH
LRGYFFYKCV PGFKGTRCEI DLDECALHPC KSGATCIDQP GNYFCQCGPP FKVVDGFSCL
CNPGYVGTRC EQNIDNCILN AFEHNSTYKD LHLSYQCVCL SGWEGNFCEQ ESNECKMNPC
KNNSTCTDLY KSYRCECTSG WTGQNCSEEI NECDSDPCMN GGLCHESTIP GQFVCLCPPL
YTGQFCHQRY NPCDLLNNPC RNNSTCLALV DGNQHCICRE EFEGKHCEID VKECLFLSCQ
DYGDCEDMVN NFRCICRPGF SGSLCEIEIN ECSSEPCKNN GTCVDLTNRF FCNCEPGYHG
PFCELEVNKC KISPCLDEEN CVYRTDRYNC LCAPGYTGIN CEINLDECLS EPCLHDGVCI
DGINHYTCDC KSGFFGTHCE TNANDCLSNP CLHGRCTEPI NEYPCSCDAD GTSIQCKIKI
NDCTSMPCMN EGFCQKSAHG FTCICPRGYT GAYCEKSIDN CAEPELNSVI CLNGGICVDG
PGHTFDCRCL PGFSGQFCEI NINECSSSPC LHGANCEDHI NGYVCKCQPG WSGHHCEKEL
ECVPNSCVHQ LCMENEPGST CLCTPGFMTC SIGLLCGDEI RRITCLTPSF QRTDPISTQT
HTVPPSETLV SSFPSIKATR IPTIMDTYPV DQGPKQTGIV KHDILPTTGL ATLRISTPLE
SYLLEELIVT RELSAKHSLL SSTDVSSSPF LNFGIHDPAQ IIQDKTSVSH MPIRTSAATL
GFFFPDRRAR TSFIMSSLMS DFIFPTQSLL FENYQTVASS ATPTTSVIRS IPGADIELNR
HSLLSRGFLL TAASISATPV VSRGAQEDIE EYSAVSLISR REHWRSLISS MSPIFPAKII
ISKQVTILNS SALHRFGTQA FIPSEYQAIT EASSNQRLTN IKSQAADSLR ELSQTCATCS
MTEIKSSHEF SDQVLHSKQS HFYETFWMNS AILASWYALM GAQTITSGHS FSSATEITPS
VAFREVPSLF PSKKSAKRTI LSSSLEESIT LSSNLDVNLC LHKTCLSIVP SQTISSDLMN
SDLTSKLTTD ELSVSENILK LLKIRQYGIT TGPTEVLNQD SLLDMEKSKG SHTPFKLHPS
DSSLDFELNL RSYPDVTLKT YSEITLANDL KNNLPPLTGS VPDFSEVTTN VAFYTVSATP
ALSIQTSSSM SVITPDWPYF IDYMTSLNKE VKTYSEWSKW ELQPSVQYQE FPTASWHLPF
TRSLTLSSLE SIVAPQQLMI SDFSCVCYYG DSYLEFQNVV LNPQNSISLE FQTFSSYGLL
LYVKQDSNLV DGFFIQLFIE NGTLKYHFYC PGEAKFKSIN TAIRVDDGQK YTLLIRQELD
PCKAELTILG RNTQTCESIN HVLGKLLPKS GSVFIGGFPD LRGKIQMPVP VKNFTGCIEV
IEINNWRSFI PSKAVRNYHI NNCRSQGLML SPTASFVDAS DVTQGVDAMW TSVSPSVAAP
SVCQEDVCHN GGTCRPIFLS SGIVSFQCDC PLHFTGRFCE KDAGLFFPSF SGNSYLELPF
LNFVLEKEHN RTVTIYLTIK TNSLNGTILY SNGNNFGKQF LHLFLVEGKP SVKYGCGNSQ
NILTVSANYS INTNAFTPIT VRHTMPIGSP GVVCMIEMTA DGKPPVQKKD TEISHASQVY
FESMFLGHIP ENVQIHKKAG SVYGFRGCIL DLQINNKEFF IIDEARRGKN IENCHVPWCA
HHLCRNNGTC LSDSENLFCE CPRLYSGKLC QFASCENNPC GNGATCVPKS ATDIICLCPY
GRSGPLCTDA INITQPRFSG TDAFGYTSFL AYSRISDISF HYEFHLKFQL ANNHSALQNN
LIFFTGQKGY GLNGDDFLAV GLLNGSVVYS YNLGSGIASI RSDPLNLSLR VHTVHLGKFF
QEGWLKVDDH KNKSIIAPGR LVGLNVFSQF YVGGYSEYTP DLLPNGADFK NGFQGCIFTL
QVRTEKDGHF RGLGNPEGHP NAGRSVGQCH ASPCSLMKCG NGGTCIESGT SVYCNCTTRW
KGAFCTETVS ICDPEHDPPH HCSRGATCIS LPHGYTCFCP LGTTGIYCEQ ALSISDPSFR
SSELSWMSFA SFHVRKKTHI QLQFQPLAAD GILFYAAQHL KAQSGDFLCI SLVNGSVQLR
YNLGDRTIIL ETLQKVTING STWHIIKAGR VGAEGYLDLD GINVTEKAST KMSSLDTNTD
FYIGGVSSLN LVNPMAIENE PVGFHGCIRQ VIINYQELQL TEFGAKGGSN VGDCDGTACG
YNTCRNGGEC RVNGTTFSCR CLPDWAGNIC NQSAYCLNNL CLHQSLCIPD QSFSYSCLCT
LGWVGRYCEN KTSFTTAKFM GNSYIKYIDP NYRMRNLQFT TISLNFSTTK TEGLIIWMGI
AQNEENDFLA IGLHNQTLKI AVNLGERISV PMSYNNGTFC CNKWHHVIVI QNQTLIKAYV
NNSLILSEDI DPHKNFVALN YEGICYLGGF EYGRKVNIVT QEIFKTNFVG KIKDVFFQDP
KKIELIKLEG YNVYDGDEQN EVT
//
