ID   A0A2K5V212_MACFA        Unreviewed;      1518 AA.
AC   A0A2K5V212;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 2.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=IQ motif containing GTPase activating protein 2 {ECO:0000313|Ensembl:ENSMFAP00000018720.2};
GN   Name=IQGAP2 {ECO:0000313|Ensembl:ENSMFAP00000018720.2};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000018720.2, ECO:0000313|Proteomes:UP000233100};
RN   [1] {ECO:0000313|Ensembl:ENSMFAP00000018720.2, ECO:0000313|Proteomes:UP000233100}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000018720.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   SMR; A0A2K5V212; -.
DR   STRING; 9541.ENSMFAP00000018720; -.
DR   Ensembl; ENSMFAT00000069267.2; ENSMFAP00000018720.2; ENSMFAG00000032362.2.
DR   VEuPathDB; HostDB:ENSMFAG00000032362; -.
DR   GeneTree; ENSGT00950000183076; -.
DR   OrthoDB; 12619at2759; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   Bgee; ENSMFAG00000032362; Expressed in liver and 13 other cell types or tissues.
DR   CDD; cd21275; CH_IQGAP2; 1.
DR   Gene3D; 1.20.5.190; -; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR023152; RasGAP_CS.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   PANTHER; PTHR14149:SF12; RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP2; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00612; IQ; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 2.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 2.
DR   PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233100}.
FT   DOMAIN          41..156
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          860..1093
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   COILED          165..192
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          1354..1381
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1518 AA;  173745 MW;  272FC72FD276C467 CRC64;
     MPREELPSLQ RPRYGSIVDD ERLSAEEMDE RRRQNIAYEY LCHLEEAKRW MEVCLVEELP
     PTTELEEGLR NGVYLAKLAK FFAPKMVSEK KIYDVEQTRY KKSGLHFRHT DNTVQWLRAM
     ESIGLPKIFY PETTDVYDRK NIPRMIYCIH ALSLYLFKLG IAPQIQDLLG KVDFTEEEIS
     NMRKELEKYG IQMPSFSKIG GILANELSVD EAALHAAVIA INEAVEKGVA EQTIVTLRNP
     NAVLTLVDDN LAPEYQKELW DAKKKKEENA RLKNSCISEE ERDAYEELLT QAEIQGNINK
     VNRQAAVDHI NAVIPEGDPE NTLLALKKPE AQLPAVYPFA AAMYQNELFN LQKQNAMNYL
     AHEELLIAVE MLSAVALLNQ ALESNDLVSV QNQLRSPTIG LNNLDKAYVE RYANTLLSVK
     LEVLSQGQDN LSWNEIQNCI DMVNAQIQEE NDRVVAVGYI NEAIDEGNPL RTLETLLLPT
     ANISDVDPAH AQHYQDVLYH AKSQKLGDSE SVSKVLWLDE IQQAVDEANV DEDRAKQWVT
     LVVDVNQCLE GKKSSDILSV LKSSTSNAND IIPECADKYY DALVKAKELK SERVSSEGSW
     LKLNLNEKYD YCYNIDSKEG SWVIPESCLY KESWLTGKEI EAFWKGCKQR KVYMHRRQTF
     IDNTDSIVKI QSWFRMATAR KSYLSRLQYF RDHNNEIVKI QSLLRANKAR DDYKTLVGSE
     NPPLTVIRKF VYLLDQSDLD FQEELEVARL REEVVTKIRA NQQLEKDLNL MDIKIGLLVK
     NRITLEDVIS HSKKLNKKKG GEMEILNNTD NQGIKSLSKE RRKTLETYQQ LFYLLQTNPL
     YLAKLIFQMP QNKSTKFMDT VIFTLYNYAS NQREEYLLLK LFKTALEEEI KSKVDQVQDI
     VTGNPTVIKM VVSFNRGARG QNTLRQLLAA VVKEIIEDKS LIINTNPVEV YKAWVNQLET
     QTGEASKLPY DVTTEQALTY PEVKNKLEAS IENLRRVTNK VLNSIISSLD LLPYGLRYIA
     KVLKNSIHEK FPDATEDELL KIVGNLLYYR YMNPAIVAPD GFDIIDMTAG GQINSDQRRN
     LGSVAKVLQH AASNKLFEGE NEHLSSMNNY LSETYQEFRK YFKEACNVPE PEEKFNMDKY
     TDLVTVSKPV IYISIEEIIS THSLLLEHQD AIAPEKNDLL SELLGSLGEV PTVESFLGEG
     AVDPNDPNKA NTLSQLSKTE ISLVLASKYD IEDGEAIDSR SLMIKTKKLI IDVIRNQPGN
     TLTEILETPA TAQQEADHAT DMVSRAMIDS RTPEEMKHSQ SMIEDAQLPL EQKKRKIQRN
     LRTLEQTGHV SSKNKYQDIL NEIAKDIRNQ RIYRKLRKAE LAKLQQTLNA LNKKAAFYEE
     QINYYDTYIK TCLDNLKRKN TRRSIKLDGK GEPKGTKRAK PVKYTAAKLH EKGVLLDIDD
     LQTNQFKNVT FDIIATEDVG IFDVRSKFLG VEMEKVQLNI QDLLQMQYEG VAVMKMFDKV
     KVNVNLLIYL LNKKFYGK
//