ID A0A2K5V2U5_MACFA Unreviewed; 4022 AA.
AC A0A2K5V2U5;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSMFAP00000019028.2};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSMFAP00000019028.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000019028.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000019028.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000019028.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMFAT00000069576.2; ENSMFAP00000019028.2; ENSMFAG00000032015.2.
DR VEuPathDB; HostDB:ENSMFAG00000032015; -.
DR GeneTree; ENSGT00940000155279; -.
DR OrthoDB; 5474900at2759; -.
DR Proteomes; UP000233100; Chromosome 5.
DR Bgee; ENSMFAG00000032015; Expressed in cerebellum and 12 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 5.
DR Pfam; PF13637; Ank_4; 3.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 3.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 78..110
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 144..176
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 247..279
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 280..312
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 313..345
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 346..378
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 379..411
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 412..444
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 445..477
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 478..510
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 511..543
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 544..576
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 577..609
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 610..642
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 643..675
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 676..708
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 709..741
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 742..774
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 775..807
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 987..1175
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1177..1323
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3573..3657
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1649..2141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2201..2415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2434..2488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2512..2590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2608..2914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2927..2956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3076..3103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3141..3182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3194..3466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3730..3757
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3780..3884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3916..3936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3994..4022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1649..1685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1741
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1768..1807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1821..1907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1973..1987
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2010..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2044..2072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2074..2095
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2104..2129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2259..2290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2297..2319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2362..2406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2524..2562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2569..2590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2608..2627
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2658..2674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2698..2725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2726..2753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2787..2802
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2818..2839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2892..2910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2930..2956
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3204..3220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3245..3287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3297..3311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3321..3335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3363..3394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3409..3438
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3446..3462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3780..3804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3813..3827
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3833..3847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3858..3881
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4022 AA; 441314 MW; 9DCB2C4207749436 CRC64;
MAHAAASIKK VREADLDEKE KNLERDRKKQ RKIPRERMER KRKSDSNASF LRAARAGNLD
KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG RGSSVDSATK KGNTALHIAS
LAGQAEVVKV LVKEGANINA QSQNGFTPLY MAAQENHIDV VKYLLENGAN QSTATEDGFT
PLAVALQQGH NQAVAILLEN DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM
VNRTTESGFT PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP LHMAAQGDHV
ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL DKRANPNARA LNGFTPLHIA
CKKNRIKVME LLVKYGASIQ AITESGLTPI HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE
TALHMAARAG QVEVVRCLLR NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA
ATTNGYTPLH ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR
RAAADSAGKN GLTPLHVAAH YDNQKVALLL LEKGASPHAT AKNGYTPLHI AAKKNQMQIA
STLLNYGAET NIVTKQGVTP LHLASQEGHT DMVTLLLDKG ANIHMSTKSG LTSLHLAAQE
DKVNVADILT KHGADQDAHT KLGYTPLIVA CHYGNVKMVN FLLKQGANVN AKTKNGYTPL
HQAAQQGHTH IINVLLQHGA KPNATTANGN TALAIAKRLG YISVVDTLKV VTEEVTTTTT
TITEKHKLNV PETMTEVLDV SDEEGDDTMT GDGGEYLRPE DLKELGDDSL PSSQFLDGMN
YLRYSLEGGR SDSTMPSLRS FSSDRSHTLS HASYLRDSAV MDDSVVIPSH QVSTLAKEAE
RNSYRLSWGT ENLDNVALSS SPIHSGFLVS FMVDARGGAM RGCRHNGLRI IIPPRKCTAP
TRVTCRLVKR HRLATMPPMV EGEGLASRLI EVGPSGAQFL GKLHLPTAPP PLNEGESLVS
RILQLGPPGT KFLGPVIVEI PHFAALRGKE RELVVLRSEN GDSWKEHFCD YTEDELNEIL
NGMDEVLDSP EDLEKKRICR IITRDFPQYF AVVSRIKQDS NLIGPEGGVL SSTVVPQVQA
VFPEGALTKR IRVGLQAQPM HTELVKKILG NKATFSPIVT LEPRRRKFHK PITMTIPVPK
ASSDVMLNGF GGDAPTLRLL CSITGGTTPA QWEDITGTTP LTFVNECVSF TTNVSARFWL
IDCRQIQESV TFASQVYREI ICVPYMAKFV VFAKSHDPIE ARLRCFCMTD DKVDKTLEQQ
ENFAEVARSR DVEVLEGKPI YVDCFGNLVP LTKSGQHHIF SFFAFKENRL PLFVKVRDTT
QEPCGRLSFM KEPKSTRGLV HQAICNLNIT LPIYTKESES DQEQEEEIDM TSEKNDETES
TETSVLKSHL VNEVPVLASP DLLSEVSEMK QDLIKMTAIL TTDVSDKAGS IKVKELVKAA
EEEPGEPFEI VERVKEDLEK VNEILRSGTC TRDEGSVQSS RSERGLVEEE WVIVSDEEIE
EARQKAPLEI TEYPCVEVRI DKEIKGKVEK DSEQLQTVQD KAGKKREALA VGKSSEKEGK
DIPPDIPPDE TQSTQKQQKP SLGIKKPVRR KLKEKQKQKE EGLQASAEKA ELKKGSSEES
LDEDPGLAPE PLPTVKATSP LIEETPIGSI KDKVKALQKR VEDEQKGRSK LPIRVKGKED
VPKKTTHRTH PAASPSLKTE RHAPGSPSSK TERHSALSSS AKTERYPPVS PSSKTEKHSP
VSPSAKTERH SPMSSSSKTE KHSPVSPSTK TERHSPVSST KTERHPPVSP SGKTDKRPPV
SPSGRTEKHP PVSPGRTEKR LPVSPSGRTD KHQPVSTAGK TEKHLPMSPS GKTEKQPPVS
PTSKTERIEE TMSVRELMKA FQSGQDPSKH KTGLFEHKSA KQKQPQEKGK VRIEKEKGPI
LTQRETQKTE NQTIKRGQRL PVTGTTESKR GVRASSIGVK KEDAAGEKEK ILSRKIPEPV
QSAPEGESHR ESEVPKEKMA DEQGDMDLQI SPDRKTSTDF SEVIKQELED NDKYQQFCLS
EETEKAQLHL DQVLTSPFNT TFPLDYMKDE FLPALSLQSG ALDGSSESLK NEGVAGSPCG
SLMEGTPQIS SEESYKHEGL AETPETSPES LSFSPKKSEE QIGETKESTK IETTTEIHSE
KEHPTTKDIT GGSEERGATV TEGSETSTEG FQKEATLGSP KDTSAKRKDD CTGSCSVALA
KETPTGLTEE AACDEDQPTF GSSDHKTQAD SEAQESTATS DETKASPLPE ASVKTDTGTE
SKPQGVIRSP QGLELALPSR DSEVLSAVAD DSLAVSHKDS LEASPVLEDN SSHKTPDSLE
PSPLKESPCR DSLESSPVEP KMKAGIFPSH FPLPAAVAKT ELLMEVASVR SRLLRDPDGS
AEDDSLEQTS LMESSGKSPL SPDTPSSEEV SYEVTPKTSD VSTPKPAVIH ECAEEDDSEN
GEKKRFTPEE EMFKMVTKIK MFDELEQEAK QKRDYKKEPK QEESSSSSDP DADCSVDVDE
PKCTGSGEDE SGVPGLVTSE SRKVSSSSES EPELTQLKKG ADSGLLPEPV IRVQPPSPLP
SSIDSNSSPE EVQFQPIVSK QYTFKMNEEI QEEPGKSEGE KDSESHLAED SHAVSTEAAD
NSFDKLNRDT DQPEICGGHG CEAMSPSSSA APVSSGLQSP TDDDIDEQPV IYKESLALQG
SHEKDTEGEE LDVSRAESPR VDCPSEGFSP SSSLPHCLVS EGKELDEDIS TTSSIQKTEI
TKTDETFENL PKDCPTQDSS ITTQTDRFSM DVPVSDLAET DEIYDRQITS PYENVPSQSF
FSSEESKTQT DANHTTSFHS SEVYSVTITS PVEDVVVASS SSGTVLSKES NFEVQDIKVE
SQQESTLWEM QSDNASSSFE PTMSATTAVV GEQISKVIIT KTDVDSDSWS EIREDDEAFE
ARVKEEEQKI FGLMVDRQSQ GTTPDTTPAR TPTEEGTPTS EQNPFLFQEG KLFEMTRSGA
IDMTKRSYAD ESFHFFQIGQ ESREETLSED VKEGATGAEP LPLETSTESL ALPESKETVD
DEADLLPDDL SEEVEEIPAS DAQLNPQMGI SASPETPTKE AVSVGTKDLP TMQTGDMPPL
SGVKQISCPD SSEPVAQVQL DFSTVTRSVY SDRGGDSPDS SPEEQKSVIE IPTAPMENVP
STESKSKIPV RTMPTYTPAP PSAEYESSLS EDLLSSVDEE NNEDEAKPKS KLPVKVPLQR
VEQQLSDLDT PVQETVAPQG QDMTSITPDN RSKSESDASS LDSKTKCPVK TRSYTETETE
SRERAEELEL ESEEGATRPK ILTSRLPVKS RSTTSSCRGG TSPTKESKEH FFDLYRNSIE
FFEEISDEAS KLVDRLTQSE REQELVSDDE SSSALEVSVI ENLPPVETEH SVPEDIFDTR
PIWDESIETL IERIPDENGH DHAEDPQDEQ ERIEERLAYI ADHLGFSWTE LARELDFTEE
QIHQIRIENP NSLQDQSHAL LKYWLERDGK HATDTNLIEC LTKINRMDIV HLMETNMEPL
QERISHSYAE IEQTITLDHS EGFSVLQEEL CTAQHKQKEE QALSKESETC DHPPIVSEED
ISVGYSTFQD GIPKTEGDSS ATALFPQTHK EQVQQDFSGK MQDLPEESSL EYRQEYFVTT
PGTEASETQK ATTVPGSPSK TPEEVSTPPE EDRLYLQTPT SSERGGSPII QEPEEPSEHR
EESSPRKTSL VIVESADNQP ETRERLDEDA AFEKGDDMPE IPPETVTEEE YIDEHGHTVV
KKVTRKIIRR YVSSEGTEKE EITVQGMPQE PVNIEEGDGY SKVIKRVVLK SDTEQSEVTL
CEPSILSSTS QFQAEPVEGR RVSKVVKTTV VRGERMEKHL GDSSLATDLP SAKDDFEEDN
NE
//
