ID A0A2K5V516_MACFA Unreviewed; 764 AA.
AC A0A2K5V516;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Kirre like nephrin family adhesion molecule 2 {ECO:0000313|Ensembl:ENSMFAP00000019826.2};
GN Name=KIRREL2 {ECO:0000313|Ensembl:ENSMFAP00000019826.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000019826.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000019826.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000019826.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR AlphaFoldDB; A0A2K5V516; -.
DR STRING; 9541.ENSMFAP00000019826; -.
DR Ensembl; ENSMFAT00000070376.2; ENSMFAP00000019826.2; ENSMFAG00000032870.2.
DR VEuPathDB; HostDB:ENSMFAG00000032870; -.
DR GeneTree; ENSGT00940000160603; -.
DR Proteomes; UP000233100; Chromosome 19.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0036057; C:slit diaphragm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR11640:SF51; KIN OF IRRE-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR11640; NEPHRIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 567..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..174
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 179..278
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 283..363
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 368..450
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 454..557
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 81196 MW; 0AE2646721DD9453 CRC64;
MSSLGGLQAR DRGSLGWGEE SSATGAPGQS DRRRASEEEV DREARATADL VNLGGHTLKM
RVPALLVLLF CFRGSAGPSP HFLQQPEDLV VLLGEEARLQ CALGAYWGLV QWTKSGLALG
GQRDLPGWSR YWISGKAANG QHDLHIRPVE LEDEASYECQ ATQAGLRSRP AQLHVLVPPE
APQVLGGPSV SLIAGVPVNL TCRSRGDARP TPELLWFRDG VRLDGTTFHQ TLLKERTPGS
VESTLTLTPS SHDDGATLVC RARSQALPAG RDTAITLSLQ YPPEVTLSAS PHTVQEGEKV
TFLCQATAQP PVTGYRWAKG GSPVLGARGP KLEVVADASF LTEPVSCEVS NTVGSANRST
ALDVLFGPIL QAKPEPVSVD VGEDASFSCA WRGNPLPRVT WTRRGGAQVL GSGATLRLPS
VGPEDAGDYV CRAEPGLSDQ GGGVAEARLT VNTPPVVTAL HSEPAFLRGP ARLQCLVFAS
PAPDAVVWSW DEGFLEAGSR GRFLVETFPA PEGRGGQGPG LISVLHISRT QESDFSRNFN
CSARNRLGEG GARASLGRRD LLPTVRIVAG VAAATTTLLM VITGVALCCW RHGKASASFS
EQKNLMRIPG SSDGCSSRGP EEEETGSRED RGPIVHTDHS DLVLEEEGTL ETKDPTNGYY
KVRGVSVSLS LGEAPGGGLF LPPPSPIGPP GAPTFYDFNP HLGMVPPCRL YRTRAGYLTT
PHPRAFTSYI KPASFGPPDL APGTPPFPYA VFPTPSHPRL QTHV
//
