ID A0A2K5V7A4_MACFA Unreviewed; 1139 AA.
AC A0A2K5V7A4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN Name=JAG1 {ECO:0000313|Ensembl:ENSMFAP00000020591.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000020591.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000020591.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000020591.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU280815}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A2K5V7A4; -.
DR STRING; 9541.ENSMFAP00000020591; -.
DR Ensembl; ENSMFAT00000035384.2; ENSMFAP00000020591.2; ENSMFAG00000033249.2.
DR VEuPathDB; HostDB:ENSMFAG00000033249; -.
DR GeneTree; ENSGT00940000160148; -.
DR OrthoDB; 5475408at2759; -.
DR Proteomes; UP000233100; Chromosome 10.
DR Bgee; ENSMFAG00000033249; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:InterPro.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 12.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 14.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR026219; Jagged/Serrate.
DR InterPro; IPR011651; Notch_ligand_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF22; DROSOPHILA CRUMBS HOMOLOG; 1.
DR Pfam; PF21700; DL-JAG_EGF-like; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF00008; EGF; 8.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF07657; MNNL; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR02059; JAGGEDFAMILY.
DR SMART; SM00051; DSL; 1.
DR SMART; SM00181; EGF; 15.
DR SMART; SM00179; EGF_CA; 13.
DR SMART; SM00214; VWC; 1.
DR SMART; SM00215; VWC_out; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS51051; DSL; 1.
DR PROSITE; PS00022; EGF_1; 14.
DR PROSITE; PS01186; EGF_2; 10.
DR PROSITE; PS50026; EGF_3; 14.
DR PROSITE; PS01187; EGF_CA; 4.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 989..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..188
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT DOMAIN 189..222
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 255..293
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 295..331
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 333..369
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 371..407
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 409..444
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 446..482
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 484..520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 545..586
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..624
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 626..662
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 665..701
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 703..739
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 741..777
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1073..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1090
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1130
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 146..155
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 159..171
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 179..188
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 212..221
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 283..292
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 321..330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 359..368
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 397..406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 413..423
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 434..443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 472..481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 510..519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 576..585
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 614..623
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 652..661
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 691..700
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 729..738
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 767..776
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1139 AA; 125314 MW; C0ABE3BBAE15B63F CRC64;
MQNVNGELQN GNCCGGARNP GDRKCTRDEC DTYFKVCLKE YQSRVTAGGP CSFGSGSTPV
IGGNTFNLKA SRGNDRNRIV LPFSFAWPRS YTLLVEAWDS SNDTVQPDSI IEKASHSGMI
NPSRQWQTLK QNTGVAHFEY QIRVTCDDYY YGFGCNKFCR PRDDFFGHYA CDQNGNKTCM
EGWMGPECNR AICRQGCSPK HGSCKLPGDC RCQYGWQGLY CDKCIPHPGC VHGICNEPWQ
CLCETNWGGQ LCDKDLNYCG THQPCLNGGT CSNTGPDKYQ CSCPEGYSGP NCEIAEHACL
SDPCHNRGSC KETSLGFECE CSPGWTGPTC STNIDDCSPN NCSHGGTCQD LVNGFKCVCP
PQWTGKTCQL DANECEAKPC VNAKSCKNLI ASYYCDCLPG WMGQNCDINI NDCLGQCQND
ASCRDLVNGY RCICPPGYAG DHCERDIDEC ASNPCLNGGH CQNEINRFQC LCPTGFSGNL
CQLDIDYCEP NPCQNGAQCY NRASDYFCKC PEDYEGKNCS HLKDHCRTTP CEVIDSCTVA
MASNDTPEGV RYISSNVCGP HGKCKSQSGG KFTCDCNKGF TGTYCHENIN DCSQNPCHNG
GTCRDLVNDF YCDCKNGWKG KTCHSRDSQC DEATCNNGGT CYDEGDAFKC MCPGGWEGTT
CNIARNSSCL PNPCHNGGTC VVNGESFTCV CKEGWEGPIC AQNTNDCSPH PCYNSGTCVD
GDNWYRCECA PGFAGPDCRI NINECQSSPC AFGATCVDEI NGYRCVCPPG HSGAKCQEVS
GRPCITMGSV IPDGAKWDDD CNTCQCLNGR IACSKVWCGP RPCLLHKGHS ECPSGQSCIP
ILDDQCFVHP CTGVGECRSS SLQPVKTKCT SDSYYQDNCA NITFTFNKEM MSPGLTTEHI
CSELRNLNIL KNVSAEYSIY IACEPSPSAN NEIHVAISAE DIRDDGNPIK EITDKIIDLV
SKRDGNSSLI AAVAEVRVQR RPLKNRTDFL VPLLSSVLTV AWICCLVTAF YWCLRKRRKP
GSHTHSASED NTTNNVREQL NQIKNPIEKH GANTVPIKDY ENKNSKMSKI RTHNSEVEED
DMDKHQQKAR FAKQPAYTLV DREEKPPNGT PTKHPNWTNK QDNRDLESAQ SLNRMEYIV
//
