ID A0A2K5V8U6_MACFA Unreviewed; 918 AA.
AC A0A2K5V8U6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL5 {ECO:0000313|Ensembl:ENSMFAP00000021138.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000021138.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000021138.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000021138.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; A0A2K5V8U6; -.
DR STRING; 9541.ENSMFAP00000021138; -.
DR Ensembl; ENSMFAT00000034886.2; ENSMFAP00000021138.2; ENSMFAG00000033431.2.
DR VEuPathDB; HostDB:ENSMFAG00000033431; -.
DR GeneTree; ENSGT00940000159535; -.
DR Proteomes; UP000233100; Chromosome 14.
DR Bgee; ENSMFAG00000033431; Expressed in lung and 10 other cell types or tissues.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13286; PH_OPR5_ORP8; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF221; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 5; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 156..273
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 805..825
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 918 AA; 102576 MW; 6B840534223CC158 CRC64;
MEPNGPPLPR DEGPPTPSSA TKVPPAEYRL CNGSDKECVS PTTRVTKKET LKVSPGPGRV
QPCHCQTDGH LSQGNHPPRL SKGGGQTTPG RLHAPCFLPC PWTPHWAGRW EDLGQLGAFS
HDPPWVPWAQ AQKENYRQEK KRATRQLLSA LTDPSVVIMA DSLKIRGTLK SWTKLWCVLK
PGVLLIYKTP KVGQWVGTVL LHCCELIERP SKKDGFCFKL FHPLDQSVWA VKGPKGESVG
SITQPLPSSY LIFRATSESD GRCWLDALEL ALRCSSLLRL GTCKPGRDGE PGTSPDASPS
SLCGLPTSAT VHPDQDLFPL NGSSLENDAF SDKSERENPE ESDTETQEHS RKTESGSDQS
ETPGVPARRG TTYVEQVQEE LGEGLTAACL PQLGEASQVE TVSEENKSLM WTLLKQLRPG
MDLSRVVLPT FVLEPRSFLN KLSDYYYHAD LLSRAAVEED AYSRMKLVLQ WYLSGFYKKP
KGIKKPYNPI LGETFRCCWF HPHTDSRTFY IAEQVSHHPP VSAFHVSNRK DGFCISGSIT
AKSRFYGNSL SALLDGKATL TFLNRAEDYT LTMPYAHCKG ILYGTMTMEL GGKVTIECAK
NNFQAELEFK LKPFFGGSTS INQISGKITS GEEVLASLSG HWDRDVFIKE EGSGSTALFW
TPSEEVRRQR LRQHTVPLEE QTELESERLW QHVTRAIGKG DQHRATQEKF ALEEAQRRRA
RERQESLTPW KPQLFHLDPT TQEWHYRYED HSPWDPLKDI AQFEQDGILR TLQQEAVARQ
TTFLGSPGPR PERSGPEQRL RKASDQPSGH SQATESSGST PESCPELSDE EQDGDFIPGG
ESPCPRCRKE ARRLQALHEA ILSIREAQQE LHRHLSAMLS STARAAQAPA PGLLQSPRSW
FLLCVFLACQ LFINHILK
//
