ID A0A2K5V9L7_MACFA Unreviewed; 859 AA.
AC A0A2K5V9L7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Polyhomeotic homolog 2 {ECO:0000313|Ensembl:ENSMFAP00000021424.2};
GN Name=PHC2 {ECO:0000313|Ensembl:ENSMFAP00000021424.2};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541 {ECO:0000313|Ensembl:ENSMFAP00000021424.2, ECO:0000313|Proteomes:UP000233100};
RN [1] {ECO:0000313|Ensembl:ENSMFAP00000021424.2, ECO:0000313|Proteomes:UP000233100}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSMFAP00000021424.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A2K5V9L7; -.
DR SMR; A0A2K5V9L7; -.
DR STRING; 9541.ENSMFAP00000021424; -.
DR Ensembl; ENSMFAT00000034585.2; ENSMFAP00000021424.2; ENSMFAG00000035555.2.
DR VEuPathDB; HostDB:ENSMFAG00000035555; -.
DR GeneTree; ENSGT00940000160840; -.
DR OrthoDB; 5399754at2759; -.
DR Proteomes; UP000233100; Chromosome 1.
DR Bgee; ENSMFAG00000035555; Expressed in cerebellum and 13 other cell types or tissues.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd09577; SAM_Ph1_2_3; 1.
DR Gene3D; 3.30.60.160; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR012313; Znf_FCS.
DR InterPro; IPR038603; Znf_FCS_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF86; POLYHOMEOTIC-LIKE PROTEIN 2; 1.
DR Pfam; PF16616; PHC2_SAM_assoc; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF21319; zf-FCS_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51024; ZF_FCS; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233100};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00367}.
FT DOMAIN 634..668
FT /note="FCS-type"
FT /evidence="ECO:0000259|PROSITE:PS51024"
FT DOMAIN 795..859
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 859 AA; 90640 MW; 0468DC34E3A1617C CRC64;
MENELPVPHT SSSACATSST SGASSSSGCN NSSSGGSGRP TGPQISVYSG IPDRQTVQVI
QQALHRQPST AAQYLQQMYA AQQQHLMLQT AALQQQHLSS AQLQSLAAVQ QASLVANRQG
STSGSNVSAQ APAQSSSINL AASPAAAQLL NRAQSVNSAA ASGIAQQAVL LGNTSSPALT
ASQAQMYLRA QMLIFTPTAT VATVQPELGT GSPARPPTPA QVQNLTLRTQ QTPAAAASGP
TPTQPVLPSL ALKPTPGSGQ PLPTPAQSRN TAQASPAGAK PGIADSVMEP LKKGDGNSSV
PGSMEGRAGL SRTVPAVAAH PLIAPAYAQL QPHQLLPQPS SKHLQPPFVI QQQPQPQQQQ
PPPQPSRPGL QAQPHPQLAS ISPSVALQPS SEAHAMPLGP VTPALPLQCP TANLHKPGGS
QQCHPPTPDA GPQNGHPEGV PHTPQRRFQH TSAVILQLQP ASPVPQQCVP DDWKEAAPGE
KSVPETRSGP SPHQQAIVTA MPGGLPVPKS PNIQSSPAHE TGQGIVHALT DLSSPGMTSG
NGNSASSIAG TAPQNGENKP PQAIVKPQIL THVIEGFVIQ EGAEPFPVGR SSLLVGNLKK
KYAQGFLPEK LPQQDHTTTT DSEMEEPYLQ ESKEEGAPLK LKCELCGRVD FAYKFKRSKR
FCSMACAKRY NVGCTKRVGL FHSDRSKLQK AGAATHNRRR ASKASLPPLT KDTKKQPTGT
VPLSVTAALQ LTHSQEDSSR CSDNSSYEEP LSPISASSST SRRRQGQRDL ELPDMHMRDL
VGMGHHFLPS EPTKWNVEDV YEFIRSLPGC QEIAEEFRAQ EIDGQALLLL KEDHLMSAMN
IKLGPALKIY ARISMLKDS
//